Correlation between Skp2 expression and nodal metastasis in Stage I and II oral squamous cell carcinomas

Abstract

Correlation between Skp2 expression and nodal metastasis in stage I and II oral squamous cell carcinomas / Tosco P; La Terra Maggiore GM; Forni P; Berrone S; Chiusa L; Garzino-Demo P. The aim of this study was to investigate the role of S-phase kinase associated protein (Skp2) in the development of nodal metastasis and to assess its influence on prognosis in stage I and II oral squamous cell carcinomas (OSCCs). Experimental Design: Seventy-one patients affected by OSCC (stage I-II) were observed in the period ranging from March 2003 to December 2006. The research was performed using immunohistochemical and histopathological analysis. Results: The overall survival rate was 89.6% at 3 years, 87% at 5 years and 80.7% at 10 years. Patients with vascular or perineural invasion showed no statistically significant survival difference when compared with the ones with no invasion. The tumour depth of invasion did not prove to be related to the metastatic potential. Nine of the seventeen patients with Skp2 positive nuclei (≥20%) developed nodal metastasis. Conversely, only 6 of the 54 patients with a nuclear positivity lower than 20% developed a laterocervical metastasis (P = 0.001). When comparing survival curves of Skp ≥ 20% and Skp2 < 20% OSCCs, no significant P value emerged from the statistical analysis. Conclusions: This study is the first to report an important correlation between an Skp2 expression lower than 20% and the capability of the tumour not to develop nodal laterocervical metastases (P = 0.001).

Acquisition of epithelial–mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells

“…Moreover, high expression of Skp2 is correlated with tumour recurrence in human cancers (Einama et al , 2006). Furthermore, the positive relationship between Skp2 expression and tumour metastasis has been reported in human malignancies (Tosco et al , 2011). Notably, Skp2 overexpression was detected more frequently in tumours metastatic to the lymph nodes in breast cancer (Zheng et al , 2005).…”

Skp2: A novel potential therapeutic target for prostate cancer

“…Recently, it has been reported that Skp2 expression correlated significantly with histological grade and tumor size in human hepatocellular carcinoma [44]. Moreover, a correlation between elevated Skp2 protein expression and tumor metastasis has been noted in multiple tumors, including melanoma [35], oral squamous cell carcinomas [45], pancreatic cancer [46], and breast carcinoma [47]. Furthermore, Skp2 expression has been discovered to predict for poor prognosis in breast cancer [47], melanoma [35], and nasopharyngeal carcinoma [36].…”

Skp2 is a Promising Therapeutic Target in Breast Cancer

“…Similarly, Skp2 expression was correlated with histological grade and tumor size in hepatocellular carcinoma (Lu et al, 2009). Moreover, elevated Skp2 expression is related with tumor metastasis in melanoma (Rose et al, 2011), lymphoma, oral squamous cell carcinomas (Tosco et al, 2011), pancreatic cancer (Einama et al, 2006), and prostate cancer (Wang et al, 2011a). Furthermore, Skp2 expression has been considered as a biomarker for poor prognosis in breast cancer (Voduc et al, 2008), melanoma (Rose et al, 2011), and nasopharyngeal carcinoma (Xu et al, 2011).…”

“…Many studies have shown the positive relationship between Skp2 expression and tumor metastasis in human cancers (Tosco et al, 2011). For example, Tosco et al (2011) found the correlation between Skp2 expression and nodal metastasis in oral squamous cell carcinomas.…”

“…Many studies have shown the positive relationship between Skp2 expression and tumor metastasis in human cancers (Tosco et al, 2011). For example, Tosco et al (2011) found the correlation between Skp2 expression and nodal metastasis in oral squamous cell carcinomas. Hung et al (2010) reported that Skp2 overexpression increased the expression of MMP-2 and MMP-9, leading to cell invasion in lung cancer cells.…”