Correlation between the complex PSA/total PSA ratio and the free PSA/total PSA ratio, sensitivity and specificity of both markers for the diagnosis of prostate cancer

Pérez-Lanzac-Lorca, A.; Barco-Sánchez, Antonio; Romero, Elaine; Martínez-Peinado, Antonio; López-Elorza, F.; Sanchez-Sanchez, E.; Alvarez-Ossorio-Fernandez, J.L.; Castiñeiras-Fernández, J.

doi:10.1016/j.acuroe.2012.11.009

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The remarkable expansion in detecting new cases of prostate cancer took place after the development of an effective diagnostic method; serum prostate specific antigen (PSA) is a useful biomarker for screening and monitoring disease progression in patients with prostate cancer [7]. PSA was first discovered in 1980 and is responsible for the liquefaction of seminal fluid and its secretion into the seminal plasma.…”

Section: Introductionmentioning

confidence: 99%

Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study

Yousif¹,

Abdalla²,

Ahmed³

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Background: Early prostate cancer antigen (EPCA), a nuclear matrix protein, has recently been recommended as a hopeful biomarker for early prostate carcinogenesis. Objectives: To evaluate the validity of serum early prostate cancer antigen (EPCA) in the early detection of prostate cancer (PCa) and the characteristics of Sudanese patients diagnosed with prostate cancer. Method: In this study, seventy men were considered as a case subject, who were diagnosed as cancer prostate at Gezira Hospital for Renal Disease and Surgery (GHRDS), Sudan during the period February 2018 to July 2019. Randomly selected sixty patients of BPH patients and forty-five apparently healthy men as controls group. EPCA, and PSA estimations were performed from serum samples using the principle of Enzyme Linked Immunosorbent Assay (ELISA). Results: There was significant association between age, family history, residence, unhealthy habits, education, BMI, occupations and prostate cancer, results also revealed a significant elevation between the means of the serum levels of both early prostate cancer antigen and prostate specific antigen of the patients with prostate cancer when compared with the control groups. EPCA biomarker offered the best performance statically (P= 0.00) and highest specificity (81%) and sensitivity (94%) in prostate cancer detection in Sudanese males over PSA biomarker. Conclusions: Cases of studied prostate cancer linked to many risk factors. Serum levels of early prostate cancer antigen and prostate specific antigen were significantly increased in patients with prostate cancer, however, our data proposed that EPCA has higher power statistical value, so could be utilized as a prostate cancer speciﬁc and sensitive biomarker for early detection of prostate cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study

Yousif¹,

Abdalla²,

Ahmed³

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

Usefulness of Total PSA Value in Prostate Diseases Diagnosis

Prcic

Begić²,

Hiros

2016

Acta Inform Med

View full text Add to dashboard Cite

Introduction:Analysis of total value of prostate specific antigen (PSAT), with the unavoidable digital rectal examination (DRE) is the basis of prostate cancer detection.Aim:The aim of this study was to determine the specificity and sensitivity of the total value of PSAT in the diagnosis of prostate cancer. The aim was also to determine the significance of PSAT in diagnosis of benign prostate hyperplasia, precancerous conditions and inflammatory and atrophic changes of the prostate.Material and methods:Data were collected from the “Register of PH biopsy” of Clinic of Urology, CCU Sarajevo.Results:Analysis of correlation between the diagnosis and the PSAT value shows statistically significant negative correlation (r =-0,186; p = 0.006) in the sense that the value of the PSAT is highest in cancer patients, and the lowest in patients with benign prostatic hyperplasia. PSAT increases with age (r = 0.152; p = 0.025). For prostate cancer optimal sensitivity and specificity for PSAT value occurs at cut off value of> 8.6 ng /mL. Values lower than 2 ng/mL and higher than 10 ng/mL are most specific, and PPV increases with increasing value of PSAT. PSAT at values of <2 ng/mL and > 10 ng/mL are at high levels of specificity, and value > 10 ng / mL is also of high sensitivity in the detection of prostate cancer, and in this moment these values represent the optimal mode for the subsequent treatment.Conclusion:PSAT has a relative significance in the detection of prostate cancer, and should not be used as a guideline without DRE.

show abstract

Correlation between the complex PSA/total PSA ratio and the free PSA/total PSA ratio, sensitivity and specificity of both markers for the diagnosis of prostate cancer

Cited by 2 publications

References 22 publications

Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study

Study on Early Prostate Cancer Antigen (EPCA) and existent risk factors of prostate cancer, Sudan: A case-control study

Usefulness of Total PSA Value in Prostate Diseases Diagnosis

Contact Info

Product

Resources

About