Correlation between the Expression of Topo IIα and Ki67 in Breast Cancer and its clinical Pathological characteristics

Jin, Jihai; Zheng, Dongxing; Liu, Yujuan

doi:10.12669/pjms.334.13143

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…The expression level increases gradually with the development of the disease. The results of this study showed that the positive expression rate of Ki67 in breast cancer tissues was significantly higher than that in adjacent tissues and the positive rate of Ki67 was related to tumor diameter and lymphatic metastasis of breast cancer (P<0.05), and the multi-factor logistic regression analysis suggested that lymphatic metastasis was the independent predictive indicator of positive expression of Ki67, which was consistent with most previous studies,16,17 It suggested that the positive expression of Ki67 was closely related to the growth, invasion and lymphatic metastasis of breast cancer and that the proliferation of breast cancer cells was active, Ki67-positive tumor cell grew fast and had high invasion and poor prognosis.…”

Section: Discussionsupporting

confidence: 91%

Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis

Sun

Wang²,

Wang³

2019

Pak J Med Sci

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Objective: Breast cancer is one of the most common malignant tumors in women, and its incidence in women has ranked the first place among all malignant cancers. The evolution of breast cancer which is highly heterogeneous is a complex biological process involving multiple factors, genes and stages. Therefore, studying the expression and interaction of related genes is of great significance to further revealing of the mechanism of the occurrence and development of breast cancer and reduction of its resistance to chemotherapy. The purpose of this study was to investigate expressions of Ki67 and Topoisomerase IIα (Topo IIα) in breast cancer tissues and to explore the relationship between expressions of Ki67 and Topo IIα and the pathological characteristics and prognosis of breast cancer. Methods: Tissues with pathological changes and peripheral normal breast tissues were collected from 66 patients who underwent breast cancer treatment. Ki67 and Topo IIα in the breast cancer tissues and normal breast tissues were detected using immunohistochemical method. The relationships of Ki67 and Topo IIα with general clinicopathologic features and prognosis were analyzed. Results: It was found that the positive expressions of Ki67 and Topo IIα in the breast cancer tissues were higher than those in the normal tissues; the positive expression rate of Ki67 was in a correlation with diameter of breast cancer and lymphatic metastasis (P<0.05); the positive expression rate of Topo IIα was in a correlation with clinical stage, diameter of cancer and lymphatic metastasis (P<0.05). Multi-factor logistic regression analysis suggested that lymphatic metastasis and clinical stage were the independent predictive factors for positive expression of Topo IIα and lymphatic metastasis was the independent predictive factor for positive expression of Ki-67. Breast cancer patients with negative Ki67 and Topo IIα had significantly higher local recurrence rate than those who had positive Ki67 and Topo IIα (P<0.05) after surgery. The median time to progression (TTP) of the patients with positive expression of Topo IIα was lower than that with negative expression (P<0.05). The median TTP of the patients with negative and positive expression of Ki67 had no significant difference (P>0.05). Conclusion: Topo IIα and Ki67 can be used for reflecting the proliferation activity of cancer cells and can affect the postoperative recurrence and survival time after surgery. They may be involved in the occurrence, development and metastasis of breast cancer. They are expected to be indicators in the prognosis prediction of breast cancer and potential treatment targets. doi: https://doi.org/10.12669/pjms.35.3.81 How to cite this:Sun G, Wang S, Wang Y. Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.81 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis

Sun

Wang²,

Wang³

2019

Pak J Med Sci

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“…Mean harvested lymph node number in axillary dissection was 15 (range [13][14][15][16][17]. Axillary status was negative in 141 (47.3%) patients and positive in 157 patients (52.7%).…”

Section: Resultsmentioning

confidence: 99%

“…It entered clinical use in 2011 St. Gallen International Expert Consensus on the Primary Therapy of Early BC [15]. In the study of Jin et al [16], they concluded that Topo II α and Ki-67 expression were well correlated with the number of metastatic lymph nodes. So, that the positive expression of Ki-67 in BC tissues can be regarded as a determinant for prognosis.…”

Section: Discussionmentioning

confidence: 99%

Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

Çakır¹,

Dogan²,

Akturk³

et al. 2020

Archives of Clinical and Experimental Medicine

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Aim: Axillary status evaluation and, if present, the number of metastatic lymph nodes is important in staging and adjuvant therapy planning of breast cancer. A number of clinical and pathological variables were analyzed to detect factors affecting nodal status. Methods: A total of 298 women with unilateral breast cancer operated with axillary lymph node dissection or sentinel lymph node biopsy, were retrospectively analyzed for age, localization, BIRADS category, pathological features, subtypes as Luminal A, Luminal B, HER2 positive, triple negative, Ki-67 index and number of lymph nodes involved. Results: The mean age was 54.7 years. BIRADS 5 was the most detected category in 208 (69.8%) patients. The most common pathological type was invasive ductal carcinoma in 265 patients (88.9%). The most detected tumor grade was grade 2 in 160 (31.2%). Luminal B was the most common subtype and detected in 173 patients (58.1%). Ki-67 indexes were detected between 0-14% in 69 patients (23.3%), between 15-19% in 31patients (10.4%) and above 20% in 198 patients (66.4%). Conclusions: HER2 positivity, Ki-67 index, and progesterone receptor negativity are the most significant factors affecting axillary lymph node metastasis.

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Correlation between the Expression of Topo IIα and Ki67 in Breast Cancer and its clinical Pathological characteristics

Cited by 2 publications

References 12 publications

Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis

Expressions of Topo IIα and Ki67 in breast cancer and its clinicopathologic features and prognosis

Impact of status of ER, PR, HER2 and Ki-67 index on axillary lymph node metastasis of breast cancer

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