Objective:To investigate the expression of Topo IIα and Ki67 and its clinical significance.Methods:The clinical pathological data of one hundred and sixteen invasive breast cancer patients who were admitted into our hospital from July 2013 to December 2015 and underwent radical mastectomy were retrospectively analyzed. The expression of topoisomerase (Topo) IIα and Ki67 was detected using immunohistochemical method, and the correlation between the two kinds of proteins and the general clinical pathological characteristics of the patients was analyzed.Results:The positive expression rates of Topo IIα and Ki67 in breast cancer were 58.6% and 75% respectively. The expression of Topo IIα was in no apparent correlation with the age, tumor size, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) (P>0.05), but in a correlation with the number of metastatic lymph glands (P<0.05). The expression of Ki67 was in no apparent correlation with the age, tumor size, EP and HER-2, but in a correlation with the number of metastatic lymph glands and PR (P<0.05). The multi-factor logistic regression analysis results suggested that the number of metastatic lymph glands was the independent predictive factor of Topo IIα positive expression and the number of metastatic lymph glands and PR protein expression state are the independent predictive factors of Ki67 positive expression.Conclusion:Topo IIα and Ki67 can be regarded as the indicators for reflecting the proliferation activity of tumor cells, and the detection of Topo IIα and Ki67 expression is of great significance to the prognosis evaluation of breast cancer patients and clinical treatment.

Purpose: To analyse and compare the clinical effects and safety of capecitabine and tegafur/gimeracil/oteracil (S-1)

Objective: To explore the clinical features of pregnancy-related breast cancer and the related factors affecting the prognosis. Methods: The research work was carried out in our hospital from January 2018 to January 2019. In this study, 50 patients were selected as related breast cancer patients and 50 non-pregnancy related breast cancer patients were selected as control group. The clinical characteristics and prognosis of the two groups were compared and analyzed. Results: According to the incidence of pregnancy-related breast cancer, the onset of breast cancer is in pregnancy and lactation, with more than half of the total number of patients having two or more pregnancies and 74.0% of the patients having breast feeding history. In the two groups, most of the patients went to see a doctor because of palpable breast masses, and the average maximum diameter of tumors in PBC group was (5.13 ± 3.22)cm, including 5 cases accompanied by dimple sign, 7 cases accompanied by nipple depression, 8 cases accompanied by inflammatory changes of skin, 3 cases with pathological changes involving whole milk, and 27 cases (54.00%) with palpable axillary enlarged lymph nodes on the same side. The average maximum value of tumor in Non-PABC group was (3.94 ± 2.11) cm, with 5 cases accompanied by dimple sign, 4 cases accompanied by nipple depression, and 9 cases (18.00%) with palpable axillary lymph nodes on the same side. Conclusion: As far as pregnancy-related breast cancer is concerned, the clinical misdiagnosis rate is relatively high and the prognosis is poor. Prenatal examination and breast-feeding breast cancer examination are needed to ensure early detection and diagnosis. This is the key factor to ensure the survival rate of pregnancy-related breast cancer patients and has positive significance for clinical development.

Objective: To explore the significance of ultrasound and ultrasound-guided coarse needle biopsy in the clinical diagnosis of breast cancer patients in pregnancy. Methods: A total of 10 patients with breast cancer in pregnancy were selected to study from October 2018 to October 2019 in our hospital, who were given preoperative ultrasound results and ultrasound-guided coarse-needle biopsy histopathology, and the results were analyzed. Results: All the 10 patients showed thickening of the mammary gland body, appeared to pick up disorderly situation, most of the dilated catheter, including 8 patients with solid hypoechoic mass, irregular shape, and "crab foot" edge burr. The corresponding aspect ratio value was greater than 1. The other 2 patients presented with cystic mixed masses with poor boundary definition, irregular shape, and mostly accompanied by posterior echo enhancement. Conclusion: Simple ultrasound diagnosis for patients with breast cancer during pregnancy has some errors, and should be used in combination with ultrasound-guided coarse needle biopsy operation. This method has a high clinical diagnosis rate and significant clinical application value, so it is worth promoting.