Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends

Ameye, Dieter; Pringels, Eveline; Foreman, P; Remon, Jean Paul; Adriaensens, Peter; Storme, Liesbet; Gelan, Jan

doi:10.1016/j.polymer.2005.01.026

Cited by 21 publications

(11 citation statements)

References 21 publications

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“…[77,112] Alternatively solution mixtures may be dried on flat surfaces resulting in mucoadhesive polymeric films [45,113] or spray-dried yielding microparticulate formulations. [114] The control of specific interactions between polymers in a common solvent is of paramount importance as insoluble complexes are often formed and it affects the properties of final dosage forms. Further consideration of the effects of specific interactions between polymers on the properties of dosage forms including their mucoadhesive performance can be found in our recent review.…”

Section: Polymeric Blends and Complexesmentioning

confidence: 99%

Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

530

421

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Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives.

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Section: Polymeric Blends and Complexesmentioning

confidence: 99%

Advances in Mucoadhesion and Mucoadhesive Polymers

Khutoryanskiy

2010

Macromolecular Bioscience

530

421

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“…[25][26][27][28][29] Like heat or mass, magnetization diffuses from areas of high magnetization to areas of low magnetization. The diffusion follows Fick's law 30 :…”

Section: Solid-state Nuclear Magnetic Resonancementioning

confidence: 99%

“…Solid-state nuclear magnetic resonance (SSNMR) has been used to characterize the domain size of solid dispersions containing two amorphous materials. [25][26][27][28][29] The spin-lattice relaxation time and the spin-lattice relaxation time in the rotating frame [T 1 ( 1 H) and T 1ρ ( 1 H), respectively] are measurable time constants for proton spin diffusion and are related to a diffusion length scale by…”

Section: Introductionmentioning

confidence: 99%

Solid-State NMR Characterization of High-Loading Solid Solutions of API and Excipients Formed by Electrospinning

Brettmann

Bell

Myerson

et al. 2012

Journal of Pharmaceutical Sciences

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“…In the past considerable effort has been dedicated to the fabrication of polymeric microspheres via spray drying, owing primarily to the favorable drug-delivery characteristics of such systems (Ameye et al 2005;Brandhonneur et al 2009;Bruinsma et al 1997;da Silva et al 2009;De Rosa et al 2005;Gomez-Gaete et al 2008;Kim et al 2000Kim et al , 2005Mi et al 2003;Mok and Park 2008;Mundargi et al 2008;Naraharisetti et al 2005;Qian et al 2009;Sivadas et al 2008;Yin and Yates 2009;Zinn et al 2001). Generally, a microcapsule/microsphere is a system containing a well-defined core and a distinct shell, with the core usually being a liquid or a solid (Mathiowitz 1999).…”

Section: Introductionmentioning

confidence: 99%

Influence of key parameters on the morphology of ethylcellulose microcapsules prepared via room-temperature spray drying

Stefanescu

2010

Cellulose

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In this contribution, the morphology of ethylcellulose (EC) microspheres prepared with a room-temperature spray-drying technique is examined as a function of solution concentration, nozzle-totarget distance, and choice of solvent. Additionally, to determine the morphology of EC microspheres in the presence of an aqueous encapsulated material, a series of encapsulation measurements was conducted using hydrogen peroxide solution as the core component. It was observed that highly concentrated EC solutions lead to the formation of tail-like fibers adjacent to the sprayed microcapsules because of the high viscosity of solutions. Furthermore, when the solutions are sprayed from relatively short nozzle-to-target distances, porous EC films are formed on the target surface along with the EC microspheres. Three nozzle-to-target distances were tested (38, 69, and 115 cm), and the optimal one was found to be 115 cm. To determine how and to what extent the solvent used in room-temperature spraydrying experiments affects the morphology of resultant microspheres, EC was dissolved in either acetone or dichloromethane (DCM), and sprayed from the resultant solutions. While microcapsules prepared from the EC-in-DCM system exhibit even, but porous wall surfaces, microspheres prepared from the EC-in-acetone solution display irregular, but cavity-free wallsurfaces. Finally, as opposed to the pure EC capsules, the ones containing H 2 O 2 solution exhibit very smooth wall surfaces; this effect was attributed to the plasticizing effect that the aqueous solution has on the ethylcellulose macromolecules.

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Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends

Cited by 21 publications

References 21 publications

Advances in Mucoadhesion and Mucoadhesive Polymers

Advances in Mucoadhesion and Mucoadhesive Polymers

Solid-State NMR Characterization of High-Loading Solid Solutions of API and Excipients Formed by Electrospinning

Influence of key parameters on the morphology of ethylcellulose microcapsules prepared via room-temperature spray drying

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