Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study

Hafsi, Sameh; Candido, Saverio; Maestro, Roberta; Falzone, Luca; Soua, Zora; Bonavida, Benjamin; Spandidos, Demetrios Α.; Libra, Massimo

doi:10.3892/ol.2015.4031

Cited by 55 publications

(40 citation statements)

References 44 publications

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“…OncomiR or Onco-suppressor role Hematological cancers OncomiR or Onco-suppressor role [91][92][93][94][95][96][97][98][99][100][101][102][103][104][105]…”

Section: Solid Tumorsmentioning

confidence: 99%

“…The role of miR-181a and b in Lymphoid cell development has been reviewed by Guarini et al [62], and specific expression profiles linked to the different steps of the maturation/differentiation process largely documented [103,104]. In a recent study, it has been shown that miR-181b directly down-regulates the expression of FAMLF (Familial acute myelogenous leukemia related factor) and inhibits cell viability by binding to the 5 UTR of FAMLF in Burkitt Lymphomas (BL), allowing the authors to suggest a new mechanism of the pathogenesis of BL, and to propose miR-181b as a candidate therapeutic agent in BL forms with FAMLF overexpression [62].…”

Section: Lymphomamentioning

confidence: 99%

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The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

116

110

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MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.

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“…OncomiR or Onco-suppressor role Hematological cancers OncomiR or Onco-suppressor role [91][92][93][94][95][96][97][98][99][100][101][102][103][104][105]…”

Section: Solid Tumorsmentioning

confidence: 99%

Section: Lymphomamentioning

confidence: 99%

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

116

110

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“…In particular, the two latter epigenetic events are now been recognized as key mechanisms of neoplastic transformation and a plethora of diseases (12,87,150). In this context, recent studies have identified different miRNAs, a class of non-coding RNA of 20-22 nucleotides, associated with the development and progression of different tumors (151)(152)(153)(154)(155)(156)(157). In addition, numerous studies have demonstrated the presence of a dual relationship between microbiota and host microRNAs (miRNAs) and vice versa (158)(159)(160).…”

Section: Possible Mechanisms Of Carcinogenesis Induced By Dysbiosismentioning

confidence: 99%

Association of oral dysbiosis with oral cancer development (Review)

et al. 2020

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Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development of human cancers. In particular, some specific bacterial strains have been recognized and strongly associated with oral cancer development (Capnocytophaga gingivalis, Fusobacterium spp., Streptococcus spp., Peptostreptococcus spp., Porphyromonas gingivalis and Prevotella spp.). Several hypotheses have been proposed to explain how the oral microbiota could be involved in cancer pathogenesis by mainly paying attention to chronic inflammation, microbial synthesis of cancerogenic substances, and alteration of epithelial barrier integrity. Based on knowledge of the carcinogenic effects of dysbiosis, it was recently suggested that probiotics may have anti-tumoral activity. Nevertheless, few data exist with regard to probiotic effects on oral cancer. On this basis, the association between the development of oral cancer and oral dysbiosis is discussed focusing attention on the potential benefits of probiotics administration in cancer prevention.

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“…International Journal of Genomics two microRNAs that targeted YY1 mRNA in Burkitt's lymphoma using miRNA target prediction tools and Pearson correlation. The two microRNAs were related to the expression of YY1 and downregulated in Burkitt's lymphoma [42]. Using two public available GEO datasets, Falzone et al reported several microRNAs that were associated with the epithelial-mesenchymal transition pathway and NGAL/MMP-9 pathways in bladder cancer [43]; the author also found four microRNAs which were related to colorectal cancer through the mismatch repair pathway and other tumor signaling pathways [44].…”

mentioning

confidence: 99%

MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer

Feng

Zhang

et al. 2020

International Journal of Genomics

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Background. Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer. hsa-miR-195 has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) in a previous study. However, the diagnostic value of hsa-miR-195-5p in lung cancer has not been investigated. Methods. To evaluate the ability of hsa-miR-195-5p to diagnose lung cancer, we compared the expression of hsa-miR-195-5p in lung cancer patients, COPD patients, and normal controls. Receiver operating characteristic (ROC) curve analysis was performed to investigate the sensitivity and specificity of hsa-miR-195-5p. Coexpression network and pathway analysis were carried out to explore the mechanism. Results. We found that hsa-miR-195-5p had lower expression in lung cancer and COPD patients than in normal controls, and the AUC was 0.92 for diagnosing lung cancer. hsa-miR-143 correlated with hsa-miR-195-5p, and by combining these two microRNAs, the AUC was 0.97 for diagnosing lung cancer. Conclusions. hsa-miR-195-5p may act as a biomarker that contributes to the diagnosis of lung cancer and the detection of its high-risk population.

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Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study

Cited by 55 publications

References 44 publications

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Association of oral dysbiosis with oral cancer development (Review)

MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer

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