Correlation between the TSHRc-Asp727Glu polymorphism and plasma thyroid stimulating hormone levels in Romanian preeclamptic women

Procopciuc, Lucia Maria; Hazi, Georgeta; Caracostea, Gabriela; Dragotoiu, Gh; Iordache, Georgiana; Olteanu, Ileana; Stamatian, Florin

doi:10.3109/09513590.2010.526658

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Maternal age is one of the essential risk factors in women with Preeclampsia. The risk of pre-eclampsia is higher when the age of pregnant women is less than 25 years [11] In the present study, the majority of the patients selected in both the groups were in the age group of 21-25 years, which comprising 50% in the control group and 50% in the preeclampsia group. However, this study shown blood pressure variation in the normotensive group was 75.60 ± 5.77 and in preeclampsia group was 101.40±10.50.…”

Section: Resultsmentioning

confidence: 52%

Relationship of Serum Leptin, Lactate Dehydrogenase Levels and Severity in Preeclampsia

Kantipudi¹

2016

TIJAR

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Section: Resultsmentioning

confidence: 52%

Relationship of Serum Leptin, Lactate Dehydrogenase Levels and Severity in Preeclampsia

Kantipudi¹

2016

TIJAR

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“…The TSHR-Glu727 variant has been proposed to have higher activity than the wild-type variant because less TSH is required to maintain normal serum free thyroxine (FT 4 ) levels (19,20,21), indicating higher sensitivity of the receptor. Previous reports have assessed the effect of the TSHR-Asp727Glu polymorphism on various clinical outcomes, including bone metabolism, glucose metabolism, and preeclampsia (21,22,23,24). Furthermore, a TSHR-mediated mechanism was proposed to be involved in stimulation of type 2 iodothyronine deiodinase (D2) expression in various tissues (7,8,15).…”

Section: Introductionmentioning

confidence: 99%

Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism

Louwerens

Appelhof

Verloop

et al. 2012

European Journal of Endocrinology

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Objective: Research on determinants of well-being in patients on thyroid hormone replacement therapy is warranted, as persistent fatigue-related complaints are common in this population. In this study, we evaluated the impact of different states of hypothyroidism on fatigue and fatigue-related symptoms. Furthermore, the relationship between fatigue and the TSH receptor (TSHR)-Asp727Glu polymorphism, a common genetic variant of the TSHR, was analyzed. Design: A cross-sectional study was performed in 278 patients (140 patients treated for differentiated thyroid carcinoma (DTC) and 138 with autoimmune hypothyroidism (AIH)) genotyped for the TSHR-Asp727Glu polymorphism. Methods: The multidimensional fatigue inventory (MFI-20) was used to assess fatigue, with higher MFI-20 scores indicating more fatigue-related complaints. MFI-20 scores were related to disease status and Asp727Glu polymorphism status. Results: AIH patients scored significantly higher than DTC patients on all five MFI-20 subscales (P!0.001), independent of clinical and thyroid hormone parameters. The frequency of the TSHR-Glu727 allele was 7.2%. Heterozygous DTC patients had more favorable MFI-20 scores than wild-type DTC patients on four of five subscales. The modest effect of the TSHR-Asp727Glu polymorphism on fatigue was found in DTC patients only. Conclusions: AIH patients had significantly higher levels of fatigue compared with DTC patients, which could not be attributed to clinical or thyroid hormone parameters. The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts.

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“…Furthermore, preeclampsia may also predispose to the development of hypothyroidism in later years after delivery [ 15 ]. It also has been suggested that attention should be paid to the monitoring of thyroid function in pregnant women with preeclampsia because of the higher risk of hypothyroidism [ 16 ]. From these considerable clinical evidences, the obviously close association between hypothyroidism and preeclampsia is established.…”

Section: Introductionmentioning

confidence: 99%

Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats

Liu

Xu²,

et al. 2021

BioMed Research International

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Background. Although hypothyroidism during pregnancy may develop grave outcomes for both mothers and offspring, management of which is still a challenge due to the insufficient understanding of this disease. The close correlation between hypothyroidism and preeclampsia is well documented, suggesting that preeclampsia is a potential risk factor for the development of maternal hypothyroidism. However, the exact role of preeclampsia in gestational hypothyroidism is still obscure. Objective. In this study, we explored the possible mechanisms of the effect of preeclampsia on thyroid function of maternal rats. Methods. Thirty pregnant rats were randomly divided into normal pregnancy control (NOP), preeclampsia (PE), and preeclampsia supplemented with amlodipine besylate (PEAml). NG-Nitro-L-arginine-methyl ester was used to induce preeclamptic symptoms. On gestational day 21, rats were sacrificed, and then, the ultrastructure of the thyroid gland, type 1 iodothyronine deiodinase (Dio1) expression, and serum-free thyroxine (FT4), free triiodothyronine (FT3), and thyroid stimulation hormones (TSH) were assessed. Results. Compared to NOP rats, results of PE rats showed that thyroid follicular cells’ ultrastructure was damaged; both hepatic Dio1 mRNA and protein levels were decreased. Interestingly, these changes were ameliorated in PEAml rats. Additionally, FT4, FT3, and TSH levels have no significant differences among groups. Conclusion. These findings indicated that preeclampsia could disrupt synthesis, secretion, and metabolism function of thyroid hormones by damaging thyroid follicular cells and interfering Dio1 expression.

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Correlation between the TSHRc-Asp727Glu polymorphism and plasma thyroid stimulating hormone levels in Romanian preeclamptic women

Abstract: Higher TSH levels and/or the TSHRc-Asp727Glu polymorphism represent risk factors for preeclampsia and could be correlated with the severity of preeclampsia.

Cited by 7 publications

References 18 publications

Relationship of Serum Leptin, Lactate Dehydrogenase Levels and Severity in Preeclampsia

Relationship of Serum Leptin, Lactate Dehydrogenase Levels and Severity in Preeclampsia

Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism

Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats

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