Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction

Qujeq, Durdi; Omran, Mohammad Taghi Salehi; Hosini, Laia

doi:10.1016/s0009-9120(01)00187-4

Cited by 54 publications

(35 citation statements)

References 30 publications

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“…In addition, the present study shows that lipid profiles were moderately elevated in patients, but, in contrast with previous studies, there was no association between the levels of total cholesterol, LDL and homocysteine 32 . Unexpectedly, only triglyceride levels were higher in controls compared to cases.…”

Section: Discussioncontrasting

confidence: 99%

Homocisteína, folato e vitamina B12 em pacientes colombianos portadores de coronariopatia

Garcia¹,

Trejos²,

Restrepo³

et al. 2007

Arq. Bras. Cardiol.

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SummaryObjective: To determine the occurrence of association between homocysteine, folate, or vitamin B12 plasma levels and acute coronary syndrome in Colombian patients.Methods: Case control study: cases were 50 patients with acute coronary syndrome and controls were 50 outpatients without coronary syndrome. Homocysteine, folate and vitamin B12 levels were determined by means of chemiluminescence immunoassay. Cholesterol and lipoproteins, triglycerides, BUN, creatinine, hemoglobin and hematocrit were also measured.Results: Mean homocysteine plasma concentrations were significantly different between cases (12.4 µmol/l ± 6.0) and controls (9.7 µmol/l ± 2.4), p=0.01. The folic acid levels of the cases were lower than those of the control patients (10.5 ng/ml ± 3.5 vs 12.6 ng/ml ± 3.6, respectively, p=0.01). An inverse relationship was found between folate and homocysteine levels. No relationship was observed between vitamin B12 levels and homocysteine levels. There was a significant difference in triglyceride levels between case and control groups (136.91 ± 67.27 vs 174.3 ± 77.6, respectively, p=0.01). The odds ratio for hyperhomocysteinemia in acute coronary syndrome was 4.45 (95% confidence interval: 1.5 -13.3). Conclusion

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Section: Discussioncontrasting

confidence: 99%

Homocisteína, folato e vitamina B12 em pacientes colombianos portadores de coronariopatia

Garcia¹,

Trejos²,

Restrepo³

et al. 2007

Arq. Bras. Cardiol.

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“…This conclusion supports the findings from another recent study by Mikael et al 4 who also reported that homocysteine inhibits apoA-I synthesis. The results of these 2 studies not only explain the documented inverse correlation between the plasma concentrations of HDL cholesterol and homocysteine 5,6 but also raise the real possibility that a homocysteineinduced inhibition of apoA-I synthesis is the mechanism linking homocysteine to the development of atherosclerosis.…”

mentioning

confidence: 75%

Homocysteine and Cardiovascular Disease

Barter

Rye

2006

Circulation Research

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“…5 Case-control studies have provided supporting data, showing that plasma Hcy is negatively correlated with HDL-C levels in patients with myocardial infarction. 6 Furthermore, we and others reported that elevated plasma Hcy concentrations in male CAD were associated with lower HDL-C. 7,8,9,10 These studies suggest that altered HDL metabolism may be mechanistically linked to cardiovascular disease (CVD) in humans.…”

mentioning

confidence: 95%

Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance

Liao

Tan

Hui

et al. 2006

Circulation Research

174

123

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Abstract-We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine ␤-synthase-/apolipoprotein E-deficient (CBS Ϫ/Ϫ /apoE Ϫ/Ϫ ) mice. We observed that plasma homocysteine (Hcy) concentrations are negatively correlated with HDL-C and apolipoprotein A1 (apoA-I) in patients with CAD. We found the loss of large HDL particles, increased HDL-free cholesterol, and decreased HDL protein in CBS Ϫ/Ϫ /apoE Ϫ/Ϫ mice, and attenuated cholesterol efflux from cholesterol-loaded macrophages to plasma in CBS Ϫ/Ϫ / apoE Ϫ/Ϫ mice. ApoA-I protein was reduced in the plasma and liver, but hepatic apoA-I mRNA was unchanged in CBS Ϫ/Ϫ /apoE Ϫ/Ϫ mice. Moreover, Hcy (0.5 to 2 mmol/L) reduced the levels of apoA-I protein but not mRNA and inhibited apoA-1 protein synthesis in mouse primary hepatocytes. Further, plasma lecithin:cholesterol acyltransferase (LCAT) substrate reactivity was decreased, LCAT specific activity increased, and plasma LCAT protein levels unchanged in apoE

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Correlation between total homocysteine, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the serum of patients with myocardial infarction

Cited by 54 publications

References 30 publications

Homocisteína, folato e vitamina B12 em pacientes colombianos portadores de coronariopatia

Homocisteína, folato e vitamina B12 em pacientes colombianos portadores de coronariopatia

Homocysteine and Cardiovascular Disease

Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance

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