Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination

Abstract

The frequency and significance of sterility is increasing due to different socio-demographic factors in the industrialized countries. At the same time, the patients' demand for more natural and less invasive fertility treatments is increasing. the most common method used in subfertility is intrauterine insemination (iUi). Retrospectively, the data from the patients were analyzed, in which at least one insemination and a maximum of eight inseminations were performed in the last five years (observation period 01.01.2014-31.12.2018) at the Women's University Hospital Homburg. The primary endpoint was the onset of a clinical pregnancy. clinical pregnancy was correlated with the partner's total sperm count (sperm density in millions), sperm concentration and motility during insemination. these three parameters were evaluated according the World Health Organization (WHO) 2010 guidelines. The results of the spermiograms were correlated with clinical pregnancy outcome. the data were examined for 138 women with sterility, in which a total of 345 inseminations were performed (median 2.5 per woman, range 8 inseminations). There was no correlation found between spermiogram parameters and pregnancy probability in any of the inseminations. After 5 inseminations no further pregnancy occurred. the present study showed no correlation between the conception probability of intrauterine insemination (iUi) and the total sperm count/concentration/motility. After the sixth iUi, we no longer found conceptions in our patient collective. therefore, data from this study indicate that intrauterine inseminations can be performed at all severity levels of oligoasthenozoospermia. However, the treatment should be limited to five attempts.

The effect of semen collection at home on intrauterine insemination outcomes

“…16,17 On the other hand, many reports have showed no relationship between motility or other semen parameters with IUI outcomes. [18][19][20] Similar to those reports, we found no existing relationships between other semen analysis parameters and IUI pregnancy outcomes. Of note, when we restricted our analysis to couples with idiopathic infertility, the above findings persisted and at-home semen collection was not related with reduced pregnancy rates.…”

Early-Pregnancy Dydrogesterone Supplementation Mimicking Luteal-Phase Support in ART Patients Did Not Provoke Major Reproductive Disorders in Pregnant Mice and Their Progeny

“…However, as male progeny of DG-treated dams did not show a reduced capability to impregnate female mice, we propose that DG-driven alterations in sperm parameters did not interfere with the overall reproductive capacity of these males. This is supported by a recent study showing no correlation between spermiogram parameters (total sperm count, sperm concentration, sperm motility) and pregnancy probability in ART patients [40].…”

Dietary supplementation with canthaxanthin and 25-hydroxycholecalciferol on the incubation performance and fertility of European quail breeders

“…It has been established that the number of sperm is correlated with the probability of fertility, and also is an indication of sperm quality ( Findeklee et al, 2020 ). Therefore, the increased in the number of sperm cells reached the infundibulum of the uterine tube of breeder supplemented with Cx + 25-OH-D 3 level, may also have increased ejaculate volume and storage conditions in the sperm storage tubules.…”