Correlation Between Tsh, T3, T4 and Histological Types of Thyroid Carcinoma

Fitriyani, Hilda; Alferraly, T. Ibnu; Laksmi, Lidya Imelda

doi:10.24293/ijcpml.v24i3.1325

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…For the papillary form, the median age at diagnosis is between 40 and 50 years old; for the follicular and medullary types, it is 50 years old; and for the poorly differentiated and undifferentiated kinds, it is 60 years old. [16] age, their risk of death and recurrence rises, especially beyond the age of 40 [17].The results of the current study found that women were more likely than males to develop thyroid cancer, and this finding was supported by data from the Chinese Cancer Incidence Study between 2007 and 2009, which showed a considerable rise in the incidence of thyroid cancer, particularly in women. There are three to four times as many ladies who contract this disease as there are males [18].…”

Section: Discussionsupporting

confidence: 80%

Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer

Hassan

Hamed

Mehdi

2022

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Thyroid cancer is one of the fastest growing malignancies in recent years, with an increase of 14.51% per year. It has been shown that there is an association between some biomarkers and the progression of thyroid cancer. In this study, we aim to assess the Neutrophil to Lymphocyte Ratio (NLR) levels and Thyroid function test (TSH, T3, T4) in patients with thyroid cancer. In the current study, (145) participants were divided into 3 groups: G1: (60 malignant thyroid gland patients, G2: (35 benign thyroid gland patients), and G3: (50 healthy control individuals as a control group). The patients attended to AL-Amal oncology Hospital in Baghdad and Imam Sadiq Hospital in Babylon province, Iraq during the period from November 2021 to February 2022. Depending on hematology analyzer the level of NLR and by Mini Vida's the TSH, T3, T4 were estimated in the studied groups. The results showed that the highest number and percentage of malignant thyroid tumors 21 (35%) was among the age group (50-≥ 60) years, while the lowest number and percentage of malignant tumors 10 (16.7%) was among the age groups (20-29) and (30-39) years. The results also demonstrated that the number and percentage of female patients with malignant thyroid tumors was 43 (71.7%) and males 17 (28.3%). A highly significant increase (P<0.01) in the levels of both NLR and TSH was observed in patients with malignant thyroid cancer when compared with their levels in the control group and benign tumor groups. The current study revealed that the age group (50-≥ 60) years and female patients were most affected by thyroid cancer and both NLR and TSH levels were highly increased in thyroid cancer patients. when compared with healthy group.

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Section: Discussionsupporting

confidence: 80%

Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer

Hassan

Hamed

Mehdi

2022

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“…Thyroid cancer is the most common endocrine cancer in the world, with Indonesia ranked 9th position in 2010 [ 1 , 2 ]. The currently available prognostic factors in thyroid cancer are the TNM classification of malignant tumors (TNM) staging, age, gender, and histopathology profile (including capsular invasion and angioinvasion) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia

et al. 2022

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Objective Thyroid cancer incidence has steadily increased in Indonesia. However, data on Kirsten rat sarcoma virus (KRAS) and EGFR mutations in thyroid cancer in Indonesia remain unavailable, except for BRAF-V600E, the most common BRAF gene mutation. This study aimed to analyze KRAS and EGFR mutation profiles in BRAF-V600E negative thyroid cancer samples. Results BRAF-V600E mutations were found in papillary thyroid carcinomas in 40.3% patients with mean age of 53 years old. In BRAF-V600E-negative samples, 41.3% had KRAS mutations with mean age of 55.5 years old. KRAS mutation was found in 52.6% of follicular carcinomas and 47.4% of papillary thyroid carcinomas. Additionally, 45.7% had EGFR mutations in patients with mean age of 50.5 years old. EGFR mutation was found in 71.4% of papillary thyroid carcinoma and 28.6% of follicular carcinoma. Nearly half of the BRAF-V600E negative thyroid carcinoma samples harbored either KRAS or EGFR mutations. This finding suggests that in BRAF-V600E negative thyroid carcinoma samples, testing for RAS and EGFR mutation may be warranted for further therapeutic consideration.

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“…An additional study reported that TSH is a principal hormone for differentiated papillary and follicular thyroid cancers [ 13 ]. In contrast, a study found insignificant differences in TSH and type of thyroid carcinomas [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was found that T3 and T4 reduced with the increasing size of thyroid nodules and that they both also decreased in malignant nodules. Regarding T3 hormone, Fitriyani et al found a significant relationship in thyroid carcinoma, and Jonklaas et al supported that patients with thyroid malignancy have lower T3 levels than patients with benign nodules [ 14 , 17 ]. In contrast to our findings, Sasson et al found that low levels of free T4 hormones enhanced the probability that a nodule was benign.…”

Section: Discussionmentioning

confidence: 99%

Can Thyrotropin, Tri-Iodothyronine, and Thyroxine Hormones be Predictors of Cancer in Thyroid Lesions?

Khider¹,

Ayad²,

Suliman³

et al. 2022

Cureus

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BackgroundThyroid nodules are a common medical problem worldwide. This study aims to investigate and elucidate the relationship between thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3), and malignant thyroid nodules. MethodsThis prospective cross-sectional study was conducted at a public specialist hospital in Saudi Arabia from February 2020 to February 2021. All thyroid nodules were scanned using ultrasound imaging, and the largest diameter was measured for each and classified according to the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TIRADS) classification system. Thyroid function tests TSH, T3, and T4 were measured. Definitive diagnoses of thyroid nodules were given based on cytology. A one-way analysis of variance (ANOVA) test was used to compare means, and cross-tabulation was used to correlate the variables in the study. ResultsA total of 222 patients participated in this study; 23.42% were male and 76.57% were females. The mean age was 44.73 ± 13.31 years (range: 18 to 85 years). The percentage of malignancy was 20.6%, 36.3%, and 91.2% in TIRADS 3, TIRADS 4, and TIRADS 5, respectively. A weak positive linear relationship was noted between nodule size and TSH (R 2 = 0.012). The study demonstrates that TSH increases in malignant nodules more than in benign nodules, while T4 and T3 are decreased in malignant nodules. ConclusionThe level of TSH increases in patients with malignant thyroid nodules more than in benign nodules, which can be used as a predictor of malignancy, while T4 and T3 reduced in malignant nodules with an ambiguous relationship.

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Correlation Between Tsh, T3, T4 and Histological Types of Thyroid Carcinoma

Cited by 4 publications

References 8 publications

Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer

Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer

High frequency of KRAS and EGFR mutation profiles in BRAF-negative thyroid carcinomas in Indonesia

Can Thyrotropin, Tri-Iodothyronine, and Thyroxine Hormones be Predictors of Cancer in Thyroid Lesions?

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