Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma

Brennan, Peter A.; Palacios-Callender, Miriam; Umar, T.; Hughes, Daniel; Spedding, Anne V.; Zaki, G.A.; Langdon, John H.

doi:10.1054/bjom.2000.0540

Cited by 18 publications

(21 citation statements)

References 28 publications

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“…Studies indicated that elevated expression of inducible nitric oxide synthase (iNOS) was observed in both human oral carcinogenesis and chemically induced oral carcinogenesis in rodents [29, 30]. Increased iNOS expression and the generation of high NO levels might lead to oral squamous cell carcinoma development [31], implying that pharmacological inhibition of iNOS and NO might be a possible strategy for oral cancer prevention.…”

Section: Discussionmentioning

confidence: 99%

Red Mold Rice Mitigates Oral Carcinogenesis in 7,12‐Dimethyl‐1,2‐Benz[a]anthracene‐Induced Oral Carcinogenesis in Hamster

Tsai¹,

Pan

2011

Evidence-Based Complementary and Alternative Medicine

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The prevalence of oral tumor has exponentially increased in recent years; however, the effective therapies or prevention strategies are not sufficient. Red mold rice is a traditional Chinese food, and several reports have demonstrated that red mold rice had an anti-tumor effect. However, the possible anti-tumor mechanisms of the red mold rice are unclear. In this study, we examined the anti-tumor effect of red mold rice on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced oral tumor in hamster. The ethanol extract of red mold rice (RMRE) treatment significantly decreases the levels of DMBA-induced reactive oxygen species, nitro oxide and prostaglandin E2 than those of the lovastatin-treated group (P < .001). Moreover, RMRE decreases the formation of oral tumor induced by DMBA. Monacolin K, monascin, ankaflavin or other red mold rice metabolites had been reported to decrease inflammation and oxidative stress and exerted anti-tumor effects. Therefore, we evaluated the anti-inflammation and anti-oxidative stress effects of monacolin K, monascin, ankaflavin and citrinin in lipopolysaccharide-treated RAW264.7 cells. We found that RMRE reduced the LPS-induced nitrite levels in RAW264.7 cells better than monacolin K, monascin, ankaflavin or citrinin (P < .05).

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Section: Discussionmentioning

confidence: 99%

Red Mold Rice Mitigates Oral Carcinogenesis in 7,12‐Dimethyl‐1,2‐Benz[a]anthracene‐Induced Oral Carcinogenesis in Hamster

Tsai¹,

Pan

2011

Evidence-Based Complementary and Alternative Medicine

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“…In addition, the activities of glutathione S-transferase (GST) and quinone reductase (QR) were assayed in the liver and tongue since certain chemopreventive compounds are known to increase the activities of detoxifying enzymes such as GST and QR [33]. The expression of inducible nitric oxide synthase (iNOS) was immunohistochemically investigated in the tongue, as iNOS is suspected to be implicated in carcinogenesis [34], including oral cancer [35, 36, 37]. …”

Section: Introductionmentioning

confidence: 99%

A Novel Geranylated Derivative, Ethyl 3-(4′-Geranyloxy-3′-Methoxyphenyl)-2-Propenoate, Synthesized from Ferulic Acid Suppresses Carcinogenesis and Inducible Nitric Oxide Synthase in Rat Tongue

Tanaka¹,

Kohno

Nomura

et al. 2003

Oncology

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Objectives: We have previously observed the inhibitory effect of ferulic acid on rat tongue carcinogenesis. In this study, we investigated the modifying effects of a novel geranylated derivative, ethyl 3-(4′-geranyloxy-3′-methoxyphenyl)-2-propenoate (EGMP), synthesized from ferulic acid on tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO). Methods: F344 male rats except those treated with EGMP alone and untreated rats were given 20 ppm 4-NQO in drinking water for 9 weeks to induce tongue neoplasms. Starting 1 week after the cessation of exposure to 4-NQO, the experimental groups given 4-NQO and a basal diet were fed the experimental diets containing EGMP (0.2% and 2%) for 20 weeks. The activities of glutathione S-transferase (GST) and quinone reductase (QR), the expression of proliferating cell nuclear antigen, polyamine content and ornithine decarboxylase activity in the tongue were examined for mechanistic analysis of modifying effects of EGMP on carcinogenesis. The expression of inducible nitric acid synthase (iNOS) was also assessed immunohistochemically. Results: At week 30, the incidence and multiplicity of tongue squamous cell carcinoma were significantly reduced by feeding of a 2% EGMP diet. EGMP feeding (2% in diet) elevated tongue GST activity and lowered QR activity in the tongue. Dietary EGMP decreased the expression of cell proliferation biomarker expression. Interestingly, EGMP feeding altered iNOS expression in the invasive parts of carcinoma. Conclusions: These results suggest that EGMP, when given at the 2% dose level during the promotion phase, exerts a chemopreventive action against tongue tumorigenesis through modification of cell proliferation activity and/or detoxifying enzymatic activity.

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“…Neuronal and endothelial NOS (nNOS, eNOS) are calciumdependent and expressed continuously in cells. In contrast, inducible NOS (iNOS) is a calcium-independent isoenzyme and is expressed in response to the release of cytokines such as interleukin-1, interferon-g and tumour necrosis factor-a 7,16 .…”

mentioning

confidence: 99%

“…Most of the cancer researches have been directed towards iNOS only, because its activation seemed to be responsible for prolonged production of NO 7 . The endothelial constitutive isoform of NOS (eNOS) represents a low-output NO pathway that is predominantly involved in homeostatic processes 18 .…”

mentioning

confidence: 99%

In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study

Shang¹,

Li²,

Li³

2006

International Journal of Oral and Maxillofacial Surgery

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Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma

Cited by 18 publications

References 28 publications

Red Mold Rice Mitigates Oral Carcinogenesis in 7,12‐Dimethyl‐1,2‐Benz[a]anthracene‐Induced Oral Carcinogenesis in Hamster

Red Mold Rice Mitigates Oral Carcinogenesis in 7,12‐Dimethyl‐1,2‐Benz[a]anthracene‐Induced Oral Carcinogenesis in Hamster

A Novel Geranylated Derivative, Ethyl 3-(4′-Geranyloxy-3′-Methoxyphenyl)-2-Propenoate, Synthesized from Ferulic Acid Suppresses Carcinogenesis and Inducible Nitric Oxide Synthase in Rat Tongue

In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study

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