Correlation between urinary albumin to creatinine ratio and systemic glycocalyx degradation in pediatric sepsis

Saragih, Rina Amalia C.; Pudjiadi, Antonius Hocky; Tambunan, Taralan; Satari, Hindra Irawan; Aulia, Diana; Bardosono, Saptawati; Munasir, Zakiudin; Lubis, Munar

doi:10.13181/mji.v27i3.2156

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…A study by Saragih et al reported that the average syndecan-1 level in healthy children was 27.7ng/mL, with a level of > 41.42ng/mL (90 th percentile) indicating marked glycocalyx degradation. ( 25 ) This suggests that syndecan-1 was increased for all pediatric sepsis subjects enrolled in this study. This is in line with several studies in adults, which reported increased levels of glycocalyx components such as syndecan-1 and hyaluronan during sepsis.…”

Section: Discussionmentioning

confidence: 71%

Correlation between syndecan-1 level and PELOD-2 score and mortality in pediatric sepsis

Pudjiadi

Saidah²,

Alatas³

2021

Crit Care Sci

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Section: Discussionmentioning

confidence: 71%

Correlation between syndecan-1 level and PELOD-2 score and mortality in pediatric sepsis

Pudjiadi

Saidah²,

Alatas³

2021

Crit Care Sci

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“…This condition leads to capillary The results of this study showed that pediatric patients with sepsis had the highest median syndecan-1 level of 2.92 (0.06 -83.00) ng/mL in the baseline measurement, slightly decreased, and continued to increase up to 2.55 (0.05 -52.40) ng/mL at the 48th-hour observation. Previous research at the pediatric ICU (PICU) Cipto Mangunkusumo Hospital, Indonesia, showed that the level of syndecan-1 in pediatric sepsis was 83.40 (10.10 -2257.91) ng/mL compared to the controls 27.7 ng/mL and that this value increased in the first three days and began to decline on the seventh day (20). Another research on the adult population at an intensive care unit (ICU) in Sweden showed that the median level of syndecan-1 in septic shock patients was 246 (180 -496) ng/mL compared to controls 26 (23 -31) ng/mL, which were not correlated with mortality (21).…”

Section: Discussionmentioning

confidence: 97%

“…Glycocalyx damage can range from discrete disturbances in the composition of the entire luminal layer to excessive destruction and degradation, with the loss of the entire glycocalyx. Furthermore, the difference in glycocalyx thickness, basal turnover, speed, and degradation severity can affect this marker's level (20).…”

Section: Discussionmentioning

confidence: 99%

Endothelial Injury in Paediatric Sepsis-associated Acute Kidney Injury

Hudaya Somasetia,

Meilyana,

Widiasta

et al. 2023

J Compr Ped

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Background: Sepsis-associated acute kidney injury (SA-AKI) is an acute kidney injury in the presence of sepsis without other significant contributing factors explaining acute kidney injury (AKI). Circulating syndecan-1, angiopoietin-2, and urinary neutrophil gelatinase-associated lipocalin levels can potentially cause neglected AKI to become acute kidney disease (AKD) and even chronic kidney disease (CKD). Therefore, studying its levels in the early phase of AKI is important, especially in SAAKI. Objectives: This study aims to analyze the levels of syndecan-1, angiopoietin-2, and urine neutrophil gelatinase-associated lipocalin (uNGAL) as other modalities that might detect AKI earlier in children with SAAKI. Methods: This study enrolled 23 children between one month and 18 years with sepsis. Blood samples were collected from all patients at the baseline, 12, 24, and 48 hours after admission to assess serum creatinine, syndecan-1, angiopoietin-2, and a urine sample was collected to measure uNGAL levels. We used the Wilcoxon signed-rank test to compare each biomarker with the time of measurement and the Mann-Whitney test to compare the levels of biomarkers with the incidence of SA-AKI. Results: The highest median value for uNGAL was 78.30 (3.20 - 24098.40) in the 12th-hour measurement; for syndecan was 2.92 (0.06 - 83.00) in the baseline measurement, slightly decreased and continued to increase up to 48 hours, and for Ang-2 was 4159.60 (17.60 - 226428.00) in the 12th-hour measurement. The incidence of SA-AKI based on the pediatric risk-injury-failure-loss-end stage (pRIFLE) criteria were that five children (21.7%) had AKI in the risk/injury phase at baseline, 24-hour, 48-hour observations, and also six children (26.1%) at 12-hour observation. Conclusion: There was an increase in levels of syndecan-1 and ang-2 in children with severe sepsis, especially in the first 24 hours.

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“…Other studies revealed that the mean urine ACR was 10.5 (3-88) mg/g, and the mean syndecan-1 level was 27.7 (SD 2.24) ng/mL (19).…”

Section: Thismentioning

confidence: 92%

Validity of Urine Syndecan-1 as A Predictor of Acute Kidney Injury In Pediatric Sepsis Patients

Semedi

Utariani

Budi

et al. 2021

IJAR

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Introduction: AKI (Acute Kidney Injury) complications in sepsis patients generally occur 24 hours after admission to ICU. Creatine Serum Concentration is a standard parameter to diagnose AKI. Unfortunately, the changes in creatine serum concentration will only be seen several days after the decrease of renal function to 50%. The low detection ability has been linked with time loss before preventive therapy is commenced. Furthermore, this instigates the need for biomarkers to ensure early detection. Objective: This study aimed to identify cut-off points of urine syndecan-1 and to measure the prediction ability of urine syndecan-1 towards the AKI occurrence in pediatric sepsis patients. Materials and methods: This study was a prospective cohort study performed at a single center in Dr. Soetomo General Hospital, Surabaya. The inclusion criterion was all children admitted to the resuscitation room from October until December 2019. Furthermore, urine sampling is carried out at 0, 6, 12, and 24 hours for a syndecan-1 urine examination, and every procedure performed on the patient will be recorded. This action was continued up to the third day and aimed to evaluate some factors related to AKI at 48-72 hours of admission. Result and Discussion: Out of 41 pediatric sepsis patients, 30 patients fulfilled the inclusion criteria and 57% had AKI. The value of urine syndecan-1 at hour-0 and hour-6 was significantly featured a cut-off point. Conclusion: The value of urine syndecan-1 at hour-0 and hour-6 are valid parameters to predict the occurrence of AKI grades 1, 2, and 3 in pediatric septic patients at 48-72 hours after their hospital admission. The best cut-off value of urine syndecan-1 at the 0th hour was 0.67 ng/ml.

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Correlation between urinary albumin to creatinine ratio and systemic glycocalyx degradation in pediatric sepsis

Cited by 4 publications

References 25 publications

Correlation between syndecan-1 level and PELOD-2 score and mortality in pediatric sepsis

Correlation between syndecan-1 level and PELOD-2 score and mortality in pediatric sepsis

Endothelial Injury in Paediatric Sepsis-associated Acute Kidney Injury

Validity of Urine Syndecan-1 as A Predictor of Acute Kidney Injury In Pediatric Sepsis Patients

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