Correlation between Virulence of Various Strains of Mycobacteria and Their Susceptibility to Ethanolic Extract of Propolis (EEP)

Scheller, S; Kawalski, H; Oklek, K; Dworniczak, Szymon; Matsuno, Tetsuya; K, Waldemar-Klimmek; Rajca, Marek; Shani, J.

doi:10.1515/znc-1998-11-1216

Cited by 11 publications

(8 citation statements)

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“…As lipids are the most abundant and distinct in the outer cell surface of mycobacteria, they easily bind such components. In previous studies we have de monstrated that the intensity of the bactericidal activity of E E P is correlated with the virulence of the m ycobacteria, and that when such virulence is augmented, the antimycobacterial activity of E E P is significantly increased (Scheller et al, 1968(Scheller et al, , 1998.…”

Section: Introductionmentioning

confidence: 98%

“…It also helps them isolate and disinfect the nests. The ethanolic extract of propolis (E E P ) exerts antibacterial, antifungal, antiviral and antiprotozoal activities, as well as the following properties: antioxidant, free radical scavenger, anticarcinogenic, immunostimulatory, radioprotective and ability to heal damaged tissues (Frankiewicz and Scheller, 1984;Grange and Davey, 1990;Matsuno, 1995;Scheller et al, 1968Scheller et al, , 1977aScheller et al, ,b,c, 1978Scheller et al, , 1988Scheller et al, , 1989aScheller et al, ,b,c, 1990Scheller et al, , 1997Scheller et al, , 1998Starzyk et al, 1977). E E P is rich in various flavonoid aglycones, phenolic compounds, sesquiterpens, diterpens, ste roids, amino acids, carboxyl-acids, aromatic alco hols and about 30 inorganic-, including trace-ele- The majority of the chemical compounds in the ethanolic extract of propolis are strong hydropho bic entities, with high affinity towards lipids.…”

Section: Introductionmentioning

confidence: 99%

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Synergism Between Ethanolic Extract of Propolis (EEP) and Anti-Tuberculosis Drugs on Growth of Mycobacteria

Scheller

Dworniczak

et al. 1999

Zeitschrift Für Naturforschung C

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Ethanolic extract of propolis exerts a strong anti-bacterial activity, in addition to antifungal. antiviral and antiprotozoal properties. In previous studies from these laboratories we have demonstrated that the intensity of the bactericidal activity of E E P is correlated with the virulence of the mycobacteria tested, and that E E P has a synergistic effect with antibiotics on growth of staphylococcus aureus. In the present study we investigated whether the same synergism and correlation exists between E E P and some anti-tuberculosis drugs on tubercu losis mycobacteria with different degrees of virulence. Six standard strains and 11 wild strains of mycobacteria were exposed for 30 days to EEP, with or without streptomycin, rifamycin, isoniazid or ethambutol. Out of the 17 strains, 8 were resistant to at least two standard antibiotics, and were considered "multi-resistant strains". The rest were either susceptible or resistant to only one of the antimycobacterial drugs. Antagonism was recorded only in one case, when Staphylococcus aureus were treated with a mixture of E E P and ethambutol, sug gesting that a chemical bond could have been formed between this anti-tuberculosis anti biotic and one of the active components of the ethanol extract of propolis.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Synergism Between Ethanolic Extract of Propolis (EEP) and Anti-Tuberculosis Drugs on Growth of Mycobacteria

Scheller

Dworniczak

et al. 1999

Zeitschrift Für Naturforschung C

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“…Propolis has a long history of use in traditional medicine and is a natural remedy found today in many health-food stores (Burdock, 1998). It has recently become the subject of increasing scientific interest due to its diverse range of biological properties, including anticariogenic (Eley, 1999;Koo et al, 2002), antiprotozoan (da Silva Cunha et al, 2004), antiinflammatory (Borrelli et al, 2002), antioxidant (Ahn et al, 2007;Isla et al, 2001), immunostimulating (Sa-Nunes et al, 2003;Orsolic et al, 2004), antiviral (Amoros et al, 1994), antitumour (Ikukatsu et al, 2002;Murata et al, 2004), hepatoprotective (Seo et al, 2003;Banskota et al, 2001), antitubercular (Scheller et al, 1998;Yildirim et al, 2004), antifungal (Ota et al, 2001) and antibacterial activity (Pepeljnjak et al, 1982;Grange and Davey, 1990;Kujumgiev et al, 1993;Sforcin et al, 2000;Santos et al, 2002;Silici and Kutluca, 2005).…”

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Comparative study of the antibacterial activity of propolis from different geographical and climatic zones

Seidel

Peyfoon

Watson

et al. 2008

Phytotherapy Research

144

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Propolis is a natural substance produced by honeybees upon collection and transformation of resins and exudates from plants. Comparative studies on propolis collected from a wide range of countries are crucial for linking its provenance to antibacterial activity and thus ensuring that the beneficial properties of propolis are used more efficiently by the general public. This study reports the in vitro screening of ethanol extracts of propolis (n = 40), collected from a wide range of countries within the tropical, subtropical and temperate zones, and on the comparison of their activity against a range of Gram-positive and Gram-negative bacteria using a broth microdilution assay. The results obtained revealed that propolis extracts were mostly active against Gram-positive bacteria. The samples were subjected to principal component analysis (PCA) in order to model their activity against Gram-positive microorganisms. Three distinct clusters were distinguished in the PCA mapping based on MIC values, categorizing samples with strong (MIC range 3.9-31.25 mg/L), moderate (MIC range 31.25-> or =500 mg/L) and weak antibacterial activity or inactivity (MIC > or = 500 mg/L only). It is hypothesized that for samples of tropical provenance differences in the activity profiles may depend on the climatic characteristics of the collection sites. High antibacterial activity was observed for samples from locations characterized by a wet-tropical rainforest-type climate.

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“…More than 300 compounds from different groups, mainly phenolic acids and their esters, aldehydes, ketons and other components, have been identified from propolis Simoes et al 2004). Flavonoids and esters of phenolic acids in propolis have been recognized as antiseptic (Dimov et al 1991), cytostatic (Frenkel et al 1993), antimicrobial (Mirzoeva et al 1997), antibiotic (Scheller et al 1998), antiviral (Kujumgiev et al 1999, antifungal (Murad et al 2002), antibacterial (Santos et al 2002) and hepatoprotective (Bhadauria et al 2007a). Adjuvant effects of propolis have also been recently reported (Khayyal et al 2003;Nirala et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Combined effects of gallic acid and propolis on beryllium‐induced hepatorenal toxicity

Nirala

Bhadauria

et al. 2008

Integrative Zoology

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The combined effect of gallic acid (3,4,5-trihydroxy benzoic acid; GA; 50 mg kg -1 i.p.) and propolis (200 mg kg -1 p.o.) was evaluated against beryllium-induced biochemical and morphological alterations in the liver and kidney. Female albino rats were exposed to beryllium nitrate (1 mg kg -1 i.p.) daily for 28 days followed by treatment with the above mentioned therapeutic agents either individually or in combination for five consecutive days. Exposure to beryllium increased its concentration in the serum, liver and kidney and caused significant alterations in cytochrome P450 enzymes, microsomal lipid peroxidation and protein contents. Beryllium administration significantly altered the aspartate aminotransaminase, alanine aminotransaminase, lactate dehydrogenase, -glutamyl transpeptidase, bilirubin, creatinine and urea in serum, and the activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phophatase and succinic dehydrogenase, triglycerides, cholesterol, protein contents, glycogen contents, lipid peroxidation and glutathione level in the liver and kidney. Beryllium exposure induced severe alterations in hepatorenal morphology, revealing its toxic consequences at a cellular level. Individual administration of GA and propolis reduced the effects on the studied parameters to a degree. Interestingly, GA in conjunction with propolis reversed the alterations in all of the variables examined, highlighting the beneficial effects of combined therapy over monotherapy in the alleviation of beryllium-induced systemic toxicity.

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Correlation between Virulence of Various Strains of Mycobacteria and Their Susceptibility to Ethanolic Extract of Propolis (EEP)

Cited by 11 publications

References 0 publications

Synergism Between Ethanolic Extract of Propolis (EEP) and Anti-Tuberculosis Drugs on Growth of Mycobacteria

Synergism Between Ethanolic Extract of Propolis (EEP) and Anti-Tuberculosis Drugs on Growth of Mycobacteria

Comparative study of the antibacterial activity of propolis from different geographical and climatic zones

Combined effects of gallic acid and propolis on beryllium‐induced hepatorenal toxicity

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