Correlation Between β-Glucan and Neutrophil/Eosinophil Ratio of Paranasal Sinus Mucosa and Blood in the Diagnosis of Chronic Fungal Rhinosinusitis

Wicaksana, Dhaniel Abdi; Suheryanto, Rus; Maharani, Iriana

doi:10.5001/omj.2018.73

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Using prevalence data from a community study from India, 26 we estimate that 293,700 people in Indonesia suffer from various manifestations of chronic fungal rhinosinusitis (FRS). These disorders do occur in Indonesia as a recent study of 20 patients with chronic fungal rhinosinusitis 49 found the level of beta‐1,3‐D glucan in the nasal wash to be a helpful diagnostic aid. In this study, 70% of the patients had Aspergillus flavus as the likely allergenic fungus, similar in frequency to the 90% found in India.…”

Section: Resultsmentioning

confidence: 99%

Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

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Background Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden help policymakers and clinicians. Objectives We have estimated the incidence and prevalence of serious fungal diseases. Methods We found all published and unpublished data and estimated the incidence and prevalence of fungal diseases based on populations at risk. HIV data were derived from UNAIDS (2017), pulmonary tuberculosis (PTB) data from 2013–2019, data on chronic pulmonary aspergillosis (CPA) were used to estimate CPA prevalence and likely deaths, COPD data from Hammond (2020), lung cancer incidence was from Globocan 2018, and fungal rhinosinusitis was estimated using community data from India. Results Overall ~7.7 million Indonesians (2.89%) have a serious fungal infection each year. The annual incidence of cryptococcosis in AIDS was 7,540. Pneumocystis pneumonia incidence was estimated at 15,400 in HIV and an equal number in non‐HIV patients. An estimated 1% and 0.2% of new AIDS patients have disseminated histoplasmosis or Talaromyces marneffei infection. The incidence of candidaemia is 26,710. The annual incidence of invasive aspergillosis was estimated at 49,500 and the prevalence of CPA is at 378,700 cases. Allergic bronchopulmonary aspergillosis prevalence in adults is estimated at 336,200, severe asthma with fungal sensitisation at 443,800, and fungal rhinosinusitis at 294,000. Recurrent vulvovaginal candidiasis is estimated at 5 million/year (15–50 years old). The incidence of fungal keratitis around 40,050. Tinea capitis prevalence in schoolchildren about 729,000. Conclusions Indonesia has a high burden of fungal infections.

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Section: Resultsmentioning

confidence: 99%

Serious fungal disease incidence and prevalence in Indonesia

Wahyuningsih

Adawiyah

Sjam

et al. 2021

Mycoses

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The Correlation of Tissue’s Endotype Biomarkers and Dominant Inflammation Cell in Chronic Rhinosinusitis

Maharani,

Intan,

Indrasworo

et al. 2024

Korean J Otorhinolaryngol-Head Neck Surg

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Background and Objectives This study analyzes the relationship between endotype biomarkers and the type of tissue inflammation in chronic rhinosinusitis (CRS) in order to obtain a more accurate division of disease groups and appropriate therapy.Subjects and Method We carried out a cross-sectional study involving 33 samples of CRS patients. We conducted enzyme-linked immunosorbent assay to examine endotype biomarkers and histopathology methods to examine tissue inflammation.Results Statistical analysis with an independent t-test showed significant differences with respect to eosinophil cationic protein (ECP) between the eosinophilic and neutrophilic groups (p<0.05), whereas there were no significant differences between the two groups (p>0.05) with respect to Charcot-Leyden crystal (CLC), interleukin-5 (IL-5), interferon gamma (IFN-γ), interleukin- 17A (IL-17A), and oncostatin M (OSM). The Spearman test showed also showed that ECP, CLC, IL-5, IL-17A, IFN-γ and OSM had no significant correlation with the two groups (p>0.05). The receiver operating characteristics analysis showed the optimal cut-off value of ECP of 342.22 pg/mL with sensitivity and specificity of 72.7% for determining the inflammation type (area under cover=0.78, p=0.009).Conclusion The higher level of ECP was more likely to be found in the eosinophilic tissue inflammation. Consequently, we propose using ECP as the main biomarker to identify the CRS type 2. Further research with a larger sample size is required for cut-off points of ECP in order to determine the endotype of CRS.

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