Correlation Factors Analysis of Breast Cancer Tumor Volume Doubling Time Measured by 3D-Ultrasound

Ding, Yan; Zhou, Qing; Wang, Cheng; Wu, Peng; Dong, Ji

doi:10.12659/msm.901566

Cited by 30 publications

(44 citation statements)

References 26 publications

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“…Precise timings of breast cancer development are difficult to assess as the moment of first cancer cell mutation is unknown. Tumor doubling time does give some estimation of the growth rate of breast carcinoma, which is suggested as 169 or 225 days for Grade 1 and 3 cancers, respectively 5 …”

Section: Introductionmentioning

confidence: 99%

Sensitivity and missed cancer rate in the symptomatic breast clinic—A retrospective cohort study of 40 323 patients

et al. 2020

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Introduction Symptomatic presentations account for the majority of invasive breast cancer diagnoses. While the National Health Service Breast Screening Programme is subjected to strict quality control, no such system for performance monitoring exists in the symptomatic clinic. We assess the sensitivity of cancer detection and missed cancer rate for symptomatic breast patients to benchmark future outcome measures. Methods A retrospective cohort study of patients attending the symptomatic breast clinic between October 2013 and October 2018 was performed. Patients with new cancer diagnoses were identified and screened for those who had presented to the department within the 3 years prior to their diagnosis. From this, the sensitivity and missed cancer rate were calculated. Results About 40 323 patients were seen over the 5‐year study period. About 2155 new cancers were diagnosed, with 2033 identified at their initial clinic attendance. A further 122 patients had cancer diagnosed on a subsequent appointment, of which 23 patients were considered to have had a delay in diagnosis. The sensitivity of the one‐stop symptomatic breast clinic was therefore 99.0%, and the missed cancer rate was 0.06% over 5 years. Conclusion The missed cancer rate reported in this study is favorable compared to the outcomes reported in the National Health Service Breast Screening Programme and superior to the only other study reporting outcomes on a much smaller cohort. The unit in question therefore is performing exceptionally against current standards and sets a benchmark against which future performance can be measured.

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Section: Introductionmentioning

confidence: 99%

Sensitivity and missed cancer rate in the symptomatic breast clinic—A retrospective cohort study of 40 323 patients

et al. 2020

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“…Tuttle et al described the tumor volume kinetics of papillary thyroid cancers based on the concept of exponential tumor growth [ 13 ]. The TV-DTs of other lesions such as breast cancers, hepatocellular cancers, and prostatic cancers have also been reported [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Slowing and Regressing of Tumor Growth in Childhood/Adolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time

Kasahara

Miyauchi

Kudo

et al. 2018

Journal of Thyroid Research

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Background Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients' PTCs might show spontaneous slowing postoperatively. We compared young PTC patients' postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT). Methods Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998–2016 had biochemically persistent disease postoperatively. We calculated their Tg-DTs and estimated their preoperative TV-DTs with the tumor size and the patient's age at surgery, presuming that a single cancer cell was present at the patient's birth. Results Twelve patients had positive Tg-DTs ranging from 2.0 to 147 years, and the remaining two had negative Tg-DTs, indicating slow growth or even regression. The hTV-DTs were 0.3–0.6 years (median 0.5 years), which were significantly shorter than the Tg-DTs (p < 0.001), indicating much faster growth preoperatively. The analyses of the nine patients without radioactive iodine administration (RAI) gave similar results (p < 0.01). Conclusions Irrespective of RAI, the patients' postoperative Tg-DTs were significantly longer than their preoperative hTV-DTs and were negative values in two patients, indicating that the growth of these young patients' PTCs had spontaneously slowed or even regressed postoperatively.

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“…Several guidelines have been proposed for clinical management of IPMNs but the quality of evidence supporting most recommendations is low (Table 1). [70][71][72][73][74][75]…”

Section: Clinical Featuresmentioning

confidence: 99%

“…79,80 Gastric-type IPMNs typically involve the branch ducts. 81 Sendai Guidelines, 2006 71 Updated Sendai Guidelines, 2012 70 American Gastroenterological Association Guidelines, 2015 72 Guideline for all cysts originating from the pancreatic duct system, suspected to be IPMN When tubular growth is extensive, these lesions have previously been designated as intraductal tubular adenoma, pyloric gland type, pyloric gland adenoma, or intraductal tubular adenoma (see Figure 8). (D) IPMN with low-grade and high-grade dysplasia.…”

Section: Pathologic Featuresmentioning

confidence: 99%

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Molecular and morphologic study of pancreatic cancer evolution

Noë¹

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Molecular evolution of intraductal neoplasms CHAPTER 2 Pathology of pancreatic cancer precursor lesions CHAPTER 3 Genomic characterization of malignant progression in neoplastic pancreatic cysts CHAPTER 4 Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4 CHAPTER 5 IPMNs with co-occurring invasive cancers: neighbours but not always relatives CHAPTER 6 Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas PART 2 Three-dimensional histopathology through tissue clearing CHAPTER 7 A "clearer" view of pancreatic pathology: a review of tissue clearing and advanced microscopy techniques CHAPTER 8 Immunolabeling of cleared human pancreata provides insights into three-dimensional pancreatic anatomy and pathology CHAPTER 9 Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion CHAPTER 10 Why is pancreatic cancer so deadly? The pathologist's view PART 3 Pancreatic neuroendocrine neoplasms CHAPTER 11 Genetic analysis of small well-differentiated pancreatic neuroendocrine tumors identifies subgroups with differing risks of liver metastases CHAPTER 12 Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1 CHAPTER 13 Well-differentiated pancreatic neuroendocrine tumor in a patient with familial atypical multiple mole melanoma syndrome (FAMMM) PART 4 Conclusion CHAPTER 14 Summarizing discussion CHAPTER 15 Nederlandse samenvatting PART 5 Appendix Curriculum Vitae

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Correlation Factors Analysis of Breast Cancer Tumor Volume Doubling Time Measured by 3D-Ultrasound

Cited by 30 publications

References 26 publications

Sensitivity and missed cancer rate in the symptomatic breast clinic—A retrospective cohort study of 40 323 patients

Sensitivity and missed cancer rate in the symptomatic breast clinic—A retrospective cohort study of 40 323 patients

Spontaneous Slowing and Regressing of Tumor Growth in Childhood/Adolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time

Molecular and morphologic study of pancreatic cancer evolution

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