Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia

Fuscaldo, Kathryn E.; Erlick, Barry J.; Fuscaldo, Anthony A.; Brodsky, Isadore; Zaccaria, Alfonso

doi:10.1016/s0304-3835(79)80020-8

Cited by 16 publications

(2 citation statements)

References 9 publications

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“…We have used non-banding Giemsa staining as a complement to the Q-and R-banding for revealing any eventual deletion in the G-chromosomes. Although different techniques have been used we could not confirm the findings by ZACCARIA and TURA ( I 978) and FUSCALDO et al ( 1979) of 2 1 q-in PT. Our results are in accordance with the report of the Third International Workshop on Chromosomes in Leukemia (1981) that chromosome abnormalities are rare in patients with PT.…”

Section: Discussionmentioning

confidence: 56%

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Cytogenetic studies on primary thrombocythaemia

2008

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Cytogenetic analysis was performed on bone marrow cells in 14 untreated patients with primary thrombocythaemia. The chromosome studies mainly concerned the G‐group, i.e. chromosomes Nos. 21 and 22. Three different staining methods were used: Giemsa without banding, Q‐banding and R‐banding. No detectable changes were observed in any of the chromosomes belonging to the G‐group. In 2 of the patients chromosome abnormalities were found (14 %). In one of them the first examination showed a normal karyotype. The abnormal clone developed several years later, although no myelosuppressive therapy was given. The frequency of abnormal clones in untreated primary thrombocythaemia is similar to that found in polycythaemia vera (14 %).

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Section: Discussionmentioning

confidence: 56%

“…Chromosome investigations in PT have been carried out without banding techniques (ROWLEY and BLAISDELL 1966;WOODLIFF et al 1967;FRICK 1969;WIIK et al 1971;GHOSH 1972) and with banding techniques (PETIT and VAN DEN BERGHE 1979;FUSCALDO et al 1979;SANDBERG 1980;RAJENDRA et al 1981). Using G-banding ZACCARIA and TURA (1978) found a deletion of chromosome No.…”

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confidence: 99%

Cytogenetic studies on primary thrombocythaemia

2008

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Cytogenetic Studies in Neoplasia (Human and Animal): Implications Prognosis, and Treatment

Whang‐Peng¹,

Knutsen²

1989

Influence of Tumor Development on the Host

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Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

Alimena¹,

Dallapiccola²,

Cuia³

et al. 1981

Hum Genet

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A terminal deletion of the long arm of one chromosome 21 at band q21 was found in two patients with acute leukemia and a low platelet count: one case of acute myelomonocytic leukemia and one case of acute lymphocytic leukemia. The segment deleted from chromosome 21 could not be found translocated to any other chromosome of the complement. The results indicate that the 21q- marker chromosome may be due to a true deletion and that the marker is no specific for primary thrombocythemia or other myeloproliferative disorders associated with thrombocytosis.

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Correlation of a specific chromosomal marker, 21q-, and retroviral indicators in patients with thrombocythemia

Cited by 16 publications

References 9 publications

Cytogenetic studies on primary thrombocythaemia

Cytogenetic studies on primary thrombocythaemia

Cytogenetic Studies in Neoplasia (Human and Animal): Implications Prognosis, and Treatment

Acute lymphocytic and myelomonocytic leukemia associated with low platelet counts and a 21q- marker chromosome

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