Correlation of acetyl‐coenzyme A carboxylase 1 with Th17 and Th1 cells, serving as a potential prognostic biomarker for acute ischemic stroke patients

Abstract

Background Acetyl‐coenzyme A carboxylase 1 (ACC1) regulates lipid homeostasis, T helper (Th) cell differentiation, oxidative stress, inflammation response, and neurological process, engaging in acute ischemic stroke (AIS) pathogenesis, while its clinical utility in AIS is unclear. Hence, this study intended to explore the correlation among blood ACC1, Th17, and Th1 cells, and ACC1’s potency as a prognostic biomarker for AIS management. Methods ACC1 in peripheral blood mononuclear cells (PBMCs) of 160 AIS patients and 30 controls were determined using RT‐qPCR; blood Th17 and Th1 cells in AIS patients were quantified by flow cytometry. Results ACC1 was increased in AIS patients compared with controls (median (interquartile range): 2.540 (1.753–3.548) vs. 0.980 (0.655–1.743), p < 0.001), which exhibited a good value to reflect AIS risk with the area under the curve of 0.872 (95% CI: 0.805–0.939). Moreover, ACC1 was positively linked with Th17 (r = 0.374, p < 0.001) and Th1 (r = 0.178, p = 0.024) cells in AIS patients. Additionally, ACC1 (r = 0.328, p < 0.001), Th17 (r = 0.272, p = 0.001), and Th1 cells (r = 0.195, p = 0.014) were positively associated with the National Institutes of Health Stroke Scale score in AIS patients. ACC1 high vs. low (p = 0.038) and Th17 high vs. low (p = 0.026) were related to shortened recurrence‐free survival (RFS) in AIS patients, while Th1 cells (p = 0.179) were not correlated with RFS. Whereas ACC1 (p = 0.248), Th17 (p = 0.079), and Th1 cells (p = 0.130) were not linked with overall survival (OS) in AIS patients. Conclusion Circulating ACC1 overexpression correlates with increased Th17, Th1 cells, NIHSS score, and shortened RFS in AIS patients.

Exploring clinical indicator variations in stroke patients with multiple risk factors: focus on hypertension and inflammatory reactions

“…In contrast, lower concentrations of CD19 affected a larger proportion of individuals than higher concentrations, contradicting prior studies. Literature reports suggest a positive correlation between elevated Th1 cells and acute ischemic stroke [ 54 ]. Similarly, within the cardioembolic stroke subtype, our findings indicated a higher incidence of elevated INF-γ concentrations, consistent with previous research.…”

Lipid Metabolism Reprogramming of Immune Cells in Acne: An Update

“…In comparison to the control group, acetylcoenzyme a carboxylase 1 (ACC1), a key enzyme in lipid homeostasis was positively linked with Th1/Th17 cells, Jiang et al recommended the correlation of ACC1 with Th17 and Th1 cells as the potential biomarker of acute ischemic stroke and implied the effect of Th1/Th17 cells in dyslipidemia. 65 The monophosphoryl lipid A had an negative effect on the Th1 cytokines and enhanced the production of the regulatory cytokine IL-10, 66 the pro-resolving lipid mediator lipoxin A4 dampened the activation of Th1/Th17 cells and reduced the inflammatory mediators. 67 In turn, Th1 cells upregulated interferon-gamma response signaling and antigen presentation pathways and downregulated lipid metabolism.…”