Correlation of adiponectin levels with disease activity score in rheumatoid arthritis patients

Abstract

Introduction: Rheumatoid arthritis is the most common chronic inflammatory joint disease of unknown etiology that primarily affects the joints and is marked by symmetric, peripheral poly arthritis. To estimation of adiponectin can be useful for early diagnosis and progression of rheumatoid arthritis. Materials and Methods: Total 90 subjects included in the present study were 60 patients were diagnosed with Rheumatoid arthritis and 30 age, gender and BMI matched healthy subjects were included as controls. biochemical, disease activity score and serum adiponectin levels were measured from all the subjects. Relevant statistical analysis was done by using SPSS and Microsoft Excel Spread Sheets. Results: Fasting blood sugars, post parandial blood sugars and triglycerides when compared to controls (P=0.0001**). Serum adiponectin concentration was found to be significantly increased in RA patients compared to healthy controls (p<0.0001). There was a significantly positive correlation between serum adiponectin and disease activity score. Conclusion: This study concludes significantly elevated levels of serum adiponectin might be used for early diagnosis and progression of rheumatoid arthritis.