Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy

Abstract

, the Karolinska Institutet Center for Innovative Medicine (Y.T.B.), the Swedish Childhood Cancer Foundation (J.-I.H., Y.T.B., M.M.), as well as the Stockholm County Council, the Swedish Cancer Foundation, and the Swedish Research Council (J.-I.H., Y.T.B.), the Cancer and Allergy Foundation of Sweden (J.-I.H.), the German Ministry of Education and Research (grant no. BMBF 01EO1303), and the German Research Foundation (grant no. SFB1160, TP1; S.E.). B.T. is also supported by a doctoral student scholarship from the Board of Postgraduate Studies at Karolinska Institutet. Computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) through the Uppsala Multidisciplinary Center for Advanced Computational Science under Project SNIC b2012204 and b2015280. Disclosure of potential conflict of interest: S. Ehl reports a grant from Deutsche Forschungsgemeinschaft (grant no. SFB1160 TP4) and a grant from BMBF (grant no. BMBF 01EO1303) during the conduct of the study and grants from Union Chimique Belge outside the submitted work. J.-I. Henter reports grants from the Swedish Childhood Cancer Foundation, the Swedish Cancer Foundation, the Swedish Research Council, the Stockholm County Council, and the Cancer and Allergy Foundation of Sweden during the conduct of the study. M. Meeths reports grants from the Swedish Childhood Cancer Foundation during the conduct of the study. The rest of the authors declare that they have no relevant conflicts of interest.

Deficiency in interleukin‐10 production by M2 macrophages in eosinophilic chronic rhinosinusitis with nasal polyps

“…Normal ethmoid sinus mucosal samples unrelated to the lesions were obtained from control subjects during surgery. Atopic status was evaluated by a skin‐prick test with a panel of aeroallergens common in our area . Allergic rhinitis was diagnosed on the concordance between a typical history of allergic symptoms and the atopy test results .…”

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

“…Skin prick tests with a panel of 19 inhalant allergens common in our region was performed, as previously described, 6 and additional information is provided in the Methods section in this article's Online Repository at www.jacionline.org.…”

“…3 Several studies using mouse models demonstrated that T FH cells orchestrated systemic IgE production in patients with allergic asthma. 4,5 Recently, we have found that increased numbers of peripheral type 2 T FH (T FH 2) cells positively correlated with upregulated IgE in patients with AR, 6 suggesting a skewed polarization of T FH 2 cells in promoting IgE production in patients with AR.…”

Increased accumulation of CD30 ligand‐positive mast cells associates with eosinophilic inflammation in nasal polyps

“…Patients undergoing septoplasty because of anatomical variations and without any other sinonasal diseases were enrolled in the study as controls. Atopic status was evaluated by a skin prick test with a panel of aeroallergens common in our area . Allergic rhinitis was diagnosed on the concordance between a typical history of allergic symptoms and the atopy test results .…”

“…Atopic status was evaluated by a skin prick test with a panel of aeroallergens common in our area. 24 Allergic rhinitis was diagnosed on the concordance between a typical history of allergic symptoms and the atopy test results. 25 The diagnosis of asthma was made based on Global Initiative for Asthma guidelines.…”