Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples

Feng, Enshan; Liang, Tingyu; Wang, Xiaoyong; Du, Juan; Tang, Kai; Wang, Xiaoxuan; Wang, Fang; You, Guoxiang

doi:10.1186/s12974-019-1418-3

Cited by 39 publications

(34 citation statements)

References 30 publications

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“…Moreover, little evidence is currently available on the functions of HLA-F with other receptors, including the inhibitory receptors ILT2, ILT4, KIR3DL1, and KIR3DL2, and the activating receptor 2DS4; their interaction and whether they are implicated in diseases have to be investigated. As previous studies revealed that an increased tumor lesion HLA-F expression has been associated with poor prognosis in patients with gliomas (71), nasopharyngeal carcinoma (26), stage II breast cancer (72), and esophageal squamous cell carcinoma (19). These findings indicated that HLA-F expression might contribute to cancer cells escaping from immune surveillance and antitumor immune responses through the binding to the inhibitory receptors such as ILT2 and ILT4 expressed on immune cells.…”

Section: Resultsmentioning

confidence: 93%

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Lin

Yan

2019

Front. Immunol.

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Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I family, the clinical significance and biological function of HLA-F have been the least investigated and have remained elusive for a long period of time. Previous studies have revealed that HLA-F expression might be involved in various physiological and pathological processes, such as pregnancy, viral infection, cancer, transplantation, and autoimmune diseases. However, recent data have shown that, akin to other HLA family members, HLA-F molecules can interact with both activating and inhibitory receptors on immune cells, such as NK cells, and can present a diverse panel of peptides. These important findings pave new avenues for investigations regarding the functions of HLA-F as an important immune regulatory molecule. In the present review, we summarize the studies on the role of HLA-F in immune modulation, with a special emphasis placed on the roles of HLA-F and KIR3DS1 interactions in viral infection.

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Section: Resultsmentioning

confidence: 93%

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Lin

Yan

2019

Front. Immunol.

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“…Therefore, researchers’ understanding of CGGA-based glioma is gradually expanding ( Liang et al, 2019 ; Wang et al, 2018 ). For example, Feng et al (2019) found that high expression of major histocompatibility complex, class I, F (HLA-F) can predict poor prognosis in patients with glioma. Guan et al (2018) showed the abnormally high expression of CKLF like MARVEL Transmembrane domain containing 6 (CMTM6) is involved in the pathophysiological process to promote poor prognosis of glioma.…”

Section: Introductionmentioning

confidence: 99%

Abnormal expression of HOXD11 promotes the malignant behavior of glioma cells and leads to poor prognosis of glioma patients

Wang

Liu

Zhang³

et al. 2021

PeerJ

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Background Homeobox D11 (HOXD11) plays an important role in a variety of cancers, but its precise role in gliomas remains unclear. This study aimed to explore the relationship between HOXD11 and gliomas by combining bioinformatics methods with basic experimental validation. Materials and methods Obtain gene expression information and clinical information of glioma and non-tumor brain tissue samples from multiple public databases such as TCGA (666 glioma samples), CGGA (749 glioma samples), GEPIA(163 glioblastoma samples and 207 normal control samples), GEO (GSE4290 and GSE15824). Nine cases of glioma tissue and five cases of normal control brain tissue were collected from the clinical department of Henan Provincial People’s Hospital for further verification. A series of bioinformatic analysis methods were used to confirm the relationship between HOXD11 expression and overall survival and clinical molecular characteristics of patients with glioma. RT-qPCR was used to verify the change of expression level of HOXD11 in glioma cells and tissues. MTT assay, colony formation assay, wound-healing assay, immunofluorescence staining, flow cytometry and western blotting were used to detect the effect of HOXD11 on the biological behavior of glioma cell line U251. Results The high expression of HOXD11 was significantly related to age, World Health Organization (WHO) grade, chemotherapy status, histological type, and even 1p19q codeletion data and isocitrate dehydrogenase (IDH) mutation. HOXD11, as an independent risk factor, reduces the overall survival of glioma patients and has diagnostic value for the prognosis of glioma. Gene Set Enrichment Analysis (GSEA) showed that HOXD11 was significantly enriched in cell signaling pathway such as cell cycle, DNA replication and so on. Finally, we confirmed that the knockout of HOXD11 can inhibit the proliferation and invasion of U251 glioma cells, and change the biological behavior of tumor cells by preventing the progression of cell cycle. Conclusions HOXD11 may be used as a candidate biomarker for the clinical application of targeted drug and prognostic assessment treatment of glioma. In addition, This study will help to explore the pathological mechanism of glioma.

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“…A growing number of immune checkpoints have been emerged as therapeutic targets and have been examined in clinical trials or clinical situations ( Ribas and Wolchok, 2018 ; Feng et al, 2019 ). Therefore, we analyzed the relationship between CD96 and other immune checkpoints, such as PD-1 , CTLA-4 , TIGIT , TIM-3 , NR2F6 , and GITR .…”

Section: Resultsmentioning

confidence: 99%

Immune and Clinical Features of CD96 Expression in Glioma by in silico Analysis

Zhang

Zhong

Fan

et al. 2020

Front. Bioeng. Biotechnol.

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Background Immune checkpoints target regulatory pathways in T cells that enhance antitumor immune responses and elicit durable clinical responses. As a novel immune checkpoint, CD96 is an attractive key target for cancer immunotherapy. However, there has been no integrative investigation of CD96 in glioma. Our study explored the relationship between CD96 expression and clinical prognosis in glioma. Methods RNA and clinical data for a total of 1,001 samples were included in this study, including 325 samples from the Chinese Glioma Genome Atlas (CGGA) database and 676 samples from The Cancer Genome Atlas (TCGA) dataset. The R programming language was employed to perform statistical analysis and draw figures. Results CD96 had a consistently positive relationship with glioblastoma and was highly enriched in IDH-wildtype and mesenchymal subtype glioma. Gene ontology enrichment and gene set variation analysis analyses suggested that CD96 was mostly involved in immune functions and was especially related to T cell-mediated immune response in glioma. Subsequent immune infiltration analysis showed that CD96 was positively correlated with infiltrating levels of CD4 + T and CD8 + T cells, macrophages, neutrophils, and DCs in glioblastoma multiforme and low-grade glioma. Additionally, CD96 was tightly associated with other immune checkpoints, including PD-1 , CTLA-4 , TIGIT , and TIM-3 . Univariate and multivariate Cox analysis demonstrated that CD96 acts as an independent indicator of poor prognosis in glioma. Conclusion CD96 expression was increased in malignant phenotype and negatively associated with overall survival in glioma. CD96 also showed a positive correlation with other immune checkpoints, immune response, and inflammatory activity. Our findings indicate that CD96 is a promising clinical target for further immunotherapeutic use in glioma patients.

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Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples

Cited by 39 publications

References 30 publications

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Abnormal expression of HOXD11 promotes the malignant behavior of glioma cells and leads to poor prognosis of glioma patients

Immune and Clinical Features of CD96 Expression in Glioma by in silico Analysis

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