Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population?

Paul, Salomi; Abbas, Muhammad s; Nassar, Sondos T; Tasha, Tasniem; Desai, Anjali; Bajgain, Anjana; ALI, ASNA; Dutta, Chandrani; Pasha, Khadija; Khan, Safeera

doi:10.7759/cureus.32712

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…The following mechanism explains the relationship between psychological factors such as anxiety and clinical manifestations caused by GERD. Certain psychological conditions such as anxiety can cause an increase in gastric acid reflux by reducing pressure on the lower esophageal sphincter, changing esophageal motility, or increasing gastric acid secretion [29].…”

Section: Resultsmentioning

confidence: 99%

The impact of COVID-19 on resident doctors as the frontline in health services

Maghfirah,

Yusuf,

Pamungkas

et al. 2024

IJPHS

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As the number of confirmed cases of COVID-19 increases, the workload due to the pandemic can affect health workers and increase the risk of psychological stress. Psychological factors such as anxiety can cause various physiological responses, including gastroesophageal reflux disease (GERD) symptoms. The persistent symptoms of GERD can reduce the patient's quality of life. A cross-sectional survey was conducted in October 2021 at the Dr. Zainoel Abidin Regional General Hospital, Banda Aceh. A total of 91 Specialist Medical Education Program responded to the study. Data from respondents were collected through the generalized anxiety disorder-7 (GAD-7), GERD-Q, and WHOQOL-BREF questionnaires. The statistical analysis used was the contingency coefficient test. The results showed that 9.9% of respondents experienced suggestive GERD, minimal anxiety (92%), and good quality of life (51.6%). There was a significant relationship between anxiety levels and quality of life and the GERD prevalence of Specialist Doctor Education Program Participants during the COVID-19 pandemic (p<0.05). Most Specialist Medical Education Program participants did not suffer from GERD with minimal anxiety, followed by mild and moderate anxiety. The majority had a good and moderate quality of life during the COVID-19 pandemic.

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Section: Resultsmentioning

confidence: 99%

The impact of COVID-19 on resident doctors as the frontline in health services

Maghfirah,

Yusuf,

Pamungkas

et al. 2024

IJPHS

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“…Simultaneously, epidemiological studies have revealed several potential risk factors for GERD, including obesity [ 16 ], smoking [ 16 ], alcohol [ 17 ], diabetes [ 18 ], depression [ 4 ] and so on. However, much of the evidence lacked reliability, displaying inconclusive outcomes across various investigations, and the precise cause-and-effect relationship of mediators in these connections was not adequately established.…”

Section: Introductionmentioning

confidence: 99%

“…However, research indicated that approximately 40% of patients, despite undergoing standard acid suppression treatment, did not achieve efficient symptom control. Additionally, prolonged PPI medication presented an elevated risk of adverse reactions, including fractures, gastrointestinal infections, and acute interstitial nephritis [4][5][6]. As a high-prevalent chronic condition, GERD presents substantial economic and health burdens to patients and society [7].…”

Section: Introductionmentioning

confidence: 99%

Investigating the causal relationship of gut microbiota with GERD and BE: a bidirectional mendelian randomization

Liu,

Yu,

Yang

et al. 2024

BMC Genomics

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Background Gut microbiota(GM) have been proven associated with lots of gastrointestinal diseases, but its causal relationship with Gastroesophageal reflux disease(GERD) and Barrett’s esophagus(BE) hasn’t been explored. We aimed to uncover the causal relation between GM and GERD/BE and potential mediators by utilizing Mendelian Randomization(MR) analysis. Methods Summary statistics of GM(comprising 301 bacteria taxa and 205 metabolism pathways) were extracted from MiBioGen Consortium(N = 18,340) and Dutch Microbiome Project(N = 7,738), GERD and BE from a multitrait meta-analysis(NGERD=602,604, NBE=56,429). Bidirectional two-sample MR analysis and linkage disequilibrium score regression(LDSC) were used to explore the genetic correlation between GM and GERD/BE. Mediation MR analysis was performed for the risk factors of GERD/BE, including Body mass index(BMI), weight, type 2 diabetes, major depressive disorder(MDD), smoking initiation, alcohol consumption, and dietary intake(including carbohydrate, sugar, fat, protein intake), to detect the potential mediators between GM and GERD/BE. Results 11 bacterial taxa and 13 metabolism pathways were found associated with GERD, and 18 taxa and 5 pathways exhibited causal relationship with BE. Mediation MR analysis suggested weight and BMI played a crucial role in these relationships. LDSC identified 1 taxon and 4 metabolism pathways related to GERD, and 1 taxon related to BE. Specie Faecalibacterium prausnitzii had a suggestive impact on both GERD(OR = 1.087, 95%CI = 1.01–1.17) and BE(OR = 1.388, 95%CI = 1.03–1.86) and LDSC had determined their correlation. Reverse MR indicated that BE impacted 10 taxa and 4 pathways. Conclusions This study established a causal link between gut microbiota and GERD/BE, and identified the probable mediators. It offers new insights into the role of gut microbiota in the development and progression of GERD and BE in the host.

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“…[4] Recurrent symptoms seriously affect the patient's quality of life, leading to sleep disorders, decreased body mass index, and an increased risk of esophageal precancerous lesions to 75% [5][6][7] . Notably, research indicates a higher incidence of depression among GERD patients compared to the healthy population, among which approximately 69% of refractory re ux symptoms associated with depression in rGERD [8,9] . This poses a challenge to PPIs in fully alleviating symptoms in affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Genetic Association Analysis Between Depression and Gastroesophageal Reflux Disease- Related Phenotypes

Xu,

Geng,

Zhang

et al. 2024

Preprint

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Objective A plethora of studies have illuminated the significant association between depression and Gastroesophageal Reflux Disease (GERD), especially refractory gastroesophageal reflux disease (rGERD), yet the causal interplay and directionality of this relationship remain largely unexplored. This study aims to shed light on the bidirectional causative connections and the potential genetic mechanisms underlying the relationship between depression and GERD, as well as its subtypes. Methods Utilizing comprehensive summary data from Genome-Wide Association Studies (GWAS) pertaining to depression, GERD, Reflux Esophagitis (RE), and Non-Erosive Reflux Disease (NERD), this study implemented Mendelian Randomization to discern the independent causal relationships between depression and these gastroesophageal disorders. We employed an integrative approach, amalgamating data from GWAS, Expression Quantitative Trait Loci (eQTL), and other multi-omics analyses. Techniques such as SMR and FUMA were applied to identify potential pathogenic genes implicated in depression and the subtypes of GERD. Enrichment analyses were conducted to elucidate the potential biological pathways through which depression modulates GERD and its variants. Results The study revealed that depression significantly increases the risk of developing GERD and NERD, but not RE. No causal link was identified between GERD, RE, NERD, and depression. In-depth analysis through SMR and FUMA pinpointed GMPPB as a potential susceptibility gene for depression, manifesting across the brain, spinal cord, and peripheral blood. For GERD, the identified susceptibility genes present in the gastroesophageal junction, esophageal mucosal and muscular layers, and peripheral blood included RP4-717I23.3, RAB7L1, BROX, TAF1B, RP11-95D17.1. For NERD, potential susceptibility genes localized in similar tissues comprised GBP3, METTL18, SERPINC1, ZNF496, AC016683.6, PAX8GLS, LARS2, NCKIPSD, QRICH1, AMT. The genetic loci linked to both depression and GERD predominantly cluster in areas such as the T cell receptor signaling pathway, DNA binding transcription factor activity, sequence-specific DNA binding, Rickman tumor differentiated well vs moderately DN, etc. Genetic loci associated with depression and NERD are mainly concentrated in areas of Nucleosome organization, Protein and complex subunit organization, and, similarly, the T cell receptor signaling, etc. Conclusion The findings of this study indicate that depression contributes to an increased incidence of GERD and NERD. The potential mechanisms underpinning this association might involve the brain-gut axis, encompassing neuroimmune pathways, DNA and RNA transcriptional regulation, and protein metabolism processes.

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Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population?

Cited by 6 publications

References 21 publications

The impact of COVID-19 on resident doctors as the frontline in health services

The impact of COVID-19 on resident doctors as the frontline in health services

Investigating the causal relationship of gut microbiota with GERD and BE: a bidirectional mendelian randomization

Genetic Association Analysis Between Depression and Gastroesophageal Reflux Disease- Related Phenotypes

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