Gastroesophageal reflux disease (GERD) is a condition characterized by the reflux of stomach contents into the esophagus which leads to heartburn and regurgitation. GERD has been categorized its types according to severity. The categories that have been discussed in this study are reflux esophagitis (RE), non-erosive reflux disease (NERD), and Barrett's esophagus. Our study compared various studies and showed that the subjects with GERD had a high level of anxiety and depression. Gastroesophageal reflux disease has a significant negative impact on the quality of life (QoL) by perturbing daily activities. The majority of GERD patients use antacid drugs to control their acid symptoms. However, these symptoms are sometimes difficult to control, even with the most potent proton-pump inhibitors (PPIs) and these patients tend to have a lower response rate. According to the clinical data, Anxiety, and Depression are linked to the development of GERD. A major focus of this study is to explore psychological influences such as anxiety and depression, and how they relate to GERD. This study also reviews the effect of these conditions on the younger population. It is concluded that the QoL of subjects with GERD is reduced by depression and anxiety.