Correlation of biological parameters with placental parameters and pregnancy outcomes in pre-eclamptic women

Moreuil, Claire de; Herry, Emma; Lacut, Karine; Chauvet, Juliette; Moineau, Marie-Pierre; Ledé, Françoise; Trémouilhac, Christophe; Merviel, Philippe; Pan‐Petesch, Brigitte; Moigne, E. Le; Marcorelles, Pascale

doi:10.1016/j.preghy.2019.12.008

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…META analysis showed that NLR has an acceptable sensitivity as a diagnostic marker for PE [54]. Neutrophil to lymphocyte ratio at time of delivery did not correlate to pregnancy outcomes (i.e., birth weight, time from pre-eclampsia diagnosis to delivery and placental parameters (being weight and number of infarcts) [55], suggesting NLR mostly reflects the general inflammatory status in these women. In addition, it has been well-established that neutrophil counts are associated with the presence of CAD and the risk of recurrent CVD events [34][35][36]56,57].…”

Section: Discussionmentioning

confidence: 88%

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Meeuwsen

Vries

Zoet

et al. 2020

Cells

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Introduction: Preeclampsia (PE) represents a hypertensive pregnancy disorder that is associated with increased cardiovascular disease (CVD) risk. This increased risk has been attributed to accelerated atherosclerosis, with inflammation being a major contributor. Neutrophils play an important role in the onset and progression of atherosclerosis and have been associated with vascular damage in the placenta as well as the chronic inflammatory state in women with PE. We therefore investigated whether circulating neutrophil numbers or reactivity were associated with the presence and severity of subclinical atherosclerosis in women with a history of PE. Methods: Women aged 45–60 years with a 10 to 20 years earlier history of early onset preeclampsia (delivery <34 weeks of gestation) (n = 90), but without symptomatic CVD burden were screened for the presence of subclinical coronary artery disease (CAD) using both contrast-enhanced and non-contrast coronary CT angiography. Subclinical CAD was defined as a coronary artery calcium (CAC) score ≥100 Agatston Units and/or ≥50% coronary luminal stenosis. We assessed whether the numbers and activity of circulating neutrophils were associated with the presence of subclinical CAD and as secondary outcome measurements, with the presence of any calcium (CAC score > 0 AU) or stenosis, categorized as absent (0%), minimal to mild (>0 and <50%), and moderate to severe (≥50%) narrowing of the coronary artery. Blood was drawn just before CT and neutrophil numbers were assessed by flow cytometry. In addition, the presence of the chemokine receptors CXCR2 and CXCR4, which are known to be instrumental in neutrophil recruitment, and neutrophil activity upon stimulation with the bacterial peptide N-Formylmethionyl-leucyl-phenylalanine (fMLF) was assessed by flow cytometry. Results: Of the participating women, with an average age of 49 years, 13% (12 out of 90) presented with subclinical signs of CAD (CAC score ≥100 AU and/or ≥50% luminal stenosis), and 37% (33 out of 90) had a positive CAC score (>0). Total white blood cell count and neutrophil counts were not associated with the presence of subclinical CAD or with a positive CAC score. When assessing the presence of the chemokine receptors CXCR4 and CXCR2, we observed a slight decrease of neutrophil CXCR2 expression in women with CAC (median MFI 22.0 [interquartile range (IQR) 20.2–23.8]) compared to women without CAC (23.8 [IQR 21.6–25.6], p = 0.02). We observed no differences regarding neutrophil CXCR4 expression. In addition, expression of the early activity marker CD35 was slightly lower on neutrophils of women with subclinical CAD (median MFI 1.6 [IQR 1.5–1.9] compared to 1.9 [IQR 1.7–2.1] in women without CAD, p = 0.02). However, for all findings, statistical significance disappeared after adjustment for multiple testing. Conclusion: Our findings indicate that neutrophil counts and (re)activity are not directly associated with silent CAD disease burden and as such are not suitable as biomarkers to predict the presence of subclinical CAD in a high-risk population of women with a history of preeclampsia.

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Section: Discussionmentioning

confidence: 88%

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Meeuwsen

Vries

Zoet

et al. 2020

Cells

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“…It has been suggested that sFlt-1/PlGF is insufficient to predict the risk of PE, and other reliable indicators are needed, of which platelet parameters have the advantages of easy, quick, and low cost (28). De Moreuil et al (29) analyzed the ROC curve for PC, MPV, PDW, and PC/MPV and found that these parameters have predictive value. Abdel et al (30) found that platelet parameters during the second trimester were higher in women who subsequently developed PE, but MPV and PDW had low predictive value and were not a good predictor of PE.…”

Section: Discussionmentioning

confidence: 99%

The clinical value of platelet parameters combined with sFlt-1/PlGF in predicting preeclampsia

Yan¹,

Sun²,

Zheng³

et al. 2021

Ann Palliat Med

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Background: The aim of this study is to evaluate the association between platelet parameters and soluble vascular endothelial growth factor receptor-1 (sFlt-1)/placenta growth factor (PlGF) in preeclampsia (PE) and establish a prediction model by analyzing commonly used biochemical markers.Methods: A nested case-control study involving 270 pregnant women in their second trimester from the Beijing Jishuitan Hospital was conducted. They were divided into PE group and control group. The levels of PlGF, sFlt-1, sFlt-1/PlGF, and platelet parameters were recorded and compared at 20-24 gestational weeks. The correlation between platelet parameters and PlGF, sFlt-1, and sFlt-1/PLGF was then analyzed.A receiver operating characteristic (ROC) curve was used to calculate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of various biomarkers in predicting PE.Results: In PE group, the levels of mean platelet volume (MPV), platelet distribution width (PDW), sFlt-1, and sFlt-1/PLGF were higher than in the control group, while the levels of platelet count (PC), PC/MPV, and PLGF in PE group were lower. Spearman correlation analysis showed that PC and PC/ MPV were negatively correlated with sFlt-1 and sFlt-1/PLGF, and positively correlated with PLGF, while further analysis found that PC/MPV had the largest area under the ROC curve with sensitivity of 83.7%

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The association between maternal placental growth factor and placental maternal vascular malperfusion lesions

Fillion

Guerby

Menzies

et al. 2021

Journal of Gynecology Obstetrics and Human Reproduction

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Correlation of biological parameters with placental parameters and pregnancy outcomes in pre-eclamptic women

Cited by 5 publications

References 43 publications

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

The clinical value of platelet parameters combined with sFlt-1/PlGF in predicting preeclampsia

The association between maternal placental growth factor and placental maternal vascular malperfusion lesions

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