Correlation of Blood Profile and CD4 Count in AIDS Patients before and after HAART, Study in Western Maharashtra

Patil, S. B.; Patil, Vaishali S.

doi:10.13005/bpj/1866

Cited by 5 publications

(6 citation statements)

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“…International Journal of Infectious Diseases 105 (2021) 495-504 Enawgaw et al, 2014;Taremwa et al, 2015;Gunda et al, 2017;Deressa et al, 2018;Fekene et al, 2018;Katemba et al, 2018;Nka et al, 2019;Tamir et al, 2019;Gebreweld et al, 2020), seven in India (Mathews et al, 2013;Kathuria et al, 2016;Kumar et al, 2016;Dhal et al, 2018;Butale, 2019;Chitra et al, 2019;Patil and Patil, 2020), one in Turkey (HEKIMO GLU et al, 2017), and one in Italy (Franzetti et al, 2014). Of the included studies, nine (45%) were conducted only in treatment-naïve HIV/AIDS patients, eight (40%) were on both treatment and treatment-naïve patients, and three (15%) were conducted only on HIV/AIDS patients having treatment.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…Eight studies were included to assess the effect of HAART on the prevalence of thrombocytopenia among HIV-infected adults (Table 3). Of them, five studies (Mathews et al, 2013;Taremwa et al, 2015;Kathuria et al, 2016;Hekimo glu et al, 2017;Patil and Patil, 2020) assess the effect of HAART using a single population before and after initiation of treatment, while the other three studies (Enawgaw et al, 2014;Fekene et al, 2018;Nka et al, 2019) had shown the effect of treatment by comparing HIV patients who were on HAART with those who were HAART naïve. The pooled effect of treatment with HAART for adults infected with HIV was found to decrease the level of thrombocytopenia by 29% (adjusted odd ratio (AOR): 0.71 (95% CI: 0.52-0.97) as compared with non-HAART initiated adults living with HIV (Figure 7).…”

Section: Effect Of Haart On Thrombocytopenia In Hiv-infected Adultsmentioning

confidence: 99%

See 1 more Smart Citation

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

Getawa

Aynalem

Bayleyegn

et al. 2021

International Journal of Infectious Diseases

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Section: Description Of Included Studiesmentioning

confidence: 99%

Section: Effect Of Haart On Thrombocytopenia In Hiv-infected Adultsmentioning

confidence: 99%

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

Getawa

Aynalem

Bayleyegn

et al. 2021

International Journal of Infectious Diseases

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“…This finding is supported by studies conducted in India where 89.2% of the cases had a CD4 count of fewer than 200 cells/l at the time of diagnosis 45 and Maharashtra where 89.2% of the cases had immunosuppression at baseline. 46 This could be due to the fact that the majority of the patients were severely immunocompromised at the outset of the research. Furthermore, HIV’s cytotoxic effect on T helper cells might cause immunosuppression, resulting in a low CD4 level.…”

Section: Discussionmentioning

confidence: 99%

Immuno-Haematological Abnormalities of HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Therapy in the Antiretroviral Therapy Clinics of Six Health Facilities at Dessie Town, Northeast Ethiopia

Tilahun¹,

Gedefie²,

Ebrahim³

et al. 2022

JBM

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Background In people living with the human immunodeficiency virus, haematological abnormalities have been linked to an increased risk of disease progression and mortality. Hematological parameters may have a positive or negative impact on antiretroviral therapy. The aim of this study was to assess the immuno-haematological abnormalities of HIV-infected patients before and after the initiation of highly active antiretroviral therapy in the antiretroviral therapy clinics of six health facilities in Dessie, Northeast Ethiopia. Methods A facility-based cross-sectional study was conducted from April to May 30, 2021, at the antiretroviral therapy clinics of six health facilities in Dessie Town. A total of 378 HIV-infected patients taking highly active antiretroviral treatment for at least 6 months by using a consecutive sampling technique were included. A well-organized questionnaire was used to collect socio-demographic and clinical information. Immune-haematological parameters were tested using a Mindray BS-300 hematology analyzer and a BD FACS count CD4 analyzer. Statistical analysis was performed using SPSS version 25 statistical software. Statistical significance was defined as a P-value of 0.05 with a 95% confidence interval. Results Leukopenia was found in 26.7% and 16.5%, neutropenia in 16.5% and 9.4%, lymphopenia in 20% and 3.1%, and thrombocytopenia in 25.9% and 7.1% of HIV patients before and after HAART initiation, respectively. There was a significant difference in total white blood cell, absolute neutrophil, red blood cell, hemoglobin value, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, red cell distribution width, platelet and CD4+ T cell counts in HIV patients before and after the initiation of HAART with P < 0.05. Conclusion and Recommendation Anemia, leukopenia, neutropenia, lymphopenia, and thrombocytopenia were the most common haematological abnormalities found in this study before and after HAART initiation. The prevalence of thrombocytopenia, immunosuppression, and viral load was reduced considerably after starting HAART.

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“…Thrombocytopenia has been reported in the literature among the HIV positive individuals previously [30] which agrees with the current results. Thrombocytopenia is the second most frequent complication of human immunodeficiency virus (HIV) infection with varied prevalence documented across the globe [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…This research demonstrates that while men are similarly susceptible to anemia brought on by HIV infection and exposure, it affects women more severely. Impaired haematopoiesis, immunemediated processes, opportunistic infections, lymphoma, and the myelotoxic effects of antiretroviral medications are some of the aetiopathogenesis factors for anemia in HIV infection [35]. Anemia in HIV-positive people has been shown in several investigations as evidenced by significantly lower mean RBC, Hb, and PCV levels [36,1].…”

Section: Discussionmentioning

confidence: 99%

Pattern of CD4 Count and Hematological Indices in HIV Serodiscordant Partners in Jos North Local Government Area of Plateau State, Nigeria

Nnamdi

Chukwuemeka

et al. 2022

AJARR

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This was a cross sectional study designed to evaluate the cluster of differentiation 4(CD4) count and hematological indices in HIV serodiscordant partners in Jos, Nigeria. A total of 20 Serodiscordant HIV couples (40 patients) and 20 non HIV couples (40 controls) aged between 18 and 49 years were included in the study. Each participant provided a 5ml venous blood sample that was collected into EDTA containers for the analysis of the CD4 count and hematological indices. The following blood parameters were measured using a three pack full blood count autoanalyzer: white blood cell (WBC), red blood cell (RBC), hematocrit/packed cell volume (HCT/PCV), hemoglobin (HB), platelet count (PLT), lymphocyte, neutrophil, and mixed cell (NUE/NAC) count. The CD4+-T cell was measured using flow cytometry. The results showed that the mean RBC count, platelet count, mixed cell count (Nue/Nac), HCT/PCV and HB levels, as well as the CD4-T cell count, were all significantly lower while the mean age was higher in the HIV serodiscordant test group compared to control group (p<0.05) respectively. The mean neutrophil, lymphocyte, and WBC counts in the HIV serodiscordant test group did not statistically differ from those in the control group (p>0.05). The HB, HCT/PCV, RBC, lymphocyte, and CD4 counts in the female HIV serodiscordant test group were statistically significantly lower than those in the female control group (p-value=0.008; 0.002; 0.000, 0.008, 0.000), respectively. The male HIV serodiscordant test group had statistically significantly lower mean neutrophil and CD4 counts than in the male control (p-value=0.000; 0.012) respectively. The female HIV seropositives had a statistically significantly lower mean RBC count, Hb, PCV, and CD4 count (p-value =0.000; 0.037, 0.005 and 0.000) than in female control respectively. Also, the female HIV exposed seronegatives had statistically significantly lower mean CD4 count (p-value =0.000) and Hb (p-value =0.037) levels than in female control while the male HIV seropositives had statistically significantly lower CD4 count compared to male control (p-value =0.000). This study has revealed significant changes in CD4-T cell count and hematological indices in HIV serodiscordant couples, which calls for an urgent interventional strategy to prevent the potential anemia, leucocytopenia, and weakened immunity that may result in both HIV seropositives and seronegative exposed couples.

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Correlation of Blood Profile and CD4 Count in AIDS Patients before and after HAART, Study in Western Maharashtra

Cited by 5 publications

References 0 publications

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

Immuno-Haematological Abnormalities of HIV-Infected Patients Before and After Initiation of Highly Active Antiretroviral Therapy in the Antiretroviral Therapy Clinics of Six Health Facilities at Dessie Town, Northeast Ethiopia

Pattern of CD4 Count and Hematological Indices in HIV Serodiscordant Partners in Jos North Local Government Area of Plateau State, Nigeria

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