Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications

Macciò, Antonio; Madeddu, Clelia; Gramignano, Giulia; Mulas, Carlo; Floris, C.; Massa, D.; Astara, Giorgio; Chessa, Paola; Mantovani, Giovanni

doi:10.1007/s00109-010-0611-8

Cited by 95 publications

(71 citation statements)

References 47 publications

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“…Several studies have implicated circulating leptin in adiposity-associated cancer development (12, 13, 30-32); reduction of leptin in this study cohort and its association with improved quality of life provides support for further investigation in cancer prevention research. Taking into account its numerous endocrine activities (including the regulation of immune function, hematopoiesis, angiogenesis, and bone development), leptin may be considered the prototype for all adipose tissue derived hormones (33). Recent publications demonstrate that improvements in PCS after bariatric surgery were observed as early as three months after intervention and were independently associated with weight loss and improvements in comorbidities (34).…”

Section: Discussionmentioning

confidence: 99%

An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research

Linkov

Burke

Komaroff

et al. 2014

Gynecologic Oncology

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OBJECTIVE Obesity has been linked to a wide spectrum of malignancies, with the strongest association demonstrated for endometrial cancer. Although the mechanisms are not yet entirely clear, a number of risk biomarkers have been proposed, including altered adipokines. Systemic levels of these adipose derived molecules have also been linked in prior research to self-reported quality of life (QOL). They study objective was to examine the hypothesis that adipokine changes during intentional weight loss may be associated with changes in QOL. METHODS Fifty-two female participants were selected from two behavioral weight loss trials (SMART and PREFER) on the basis of achieving successful weight loss at 6 month assessment, availability of blood samples and completion of standard SF-36 QOL questionnaires. Levels of adiponectin, leptin, and resistin were measured using xMAP immunoassays. Changes in QOL were examined using linear regression models in relation to pre- and post-intervention changes in biomarker levels and BMI. RESULTS Significant changes between pre- and post-intervention were observed for leptin. Controlling for baseline BMI, leptin was the only biomarker that predicted change in QOL (Physical Component Scale, PCS). Linear regression models demonstrated that leptin continued to be a significant predictor of change in PCS when other possible predictor variables were included in the model. CONCLUSIONS This study is among the first to demonstrate that changes in PCS may be regulated by levels of both metabolic variables and adipokines. An improved understanding of biological mechanisms associated with weight loss and the role of QOL may help guide preventive strategies for obesity-associated cancers.

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Section: Discussionmentioning

confidence: 99%

An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research

Linkov

Burke

Komaroff

et al. 2014

Gynecologic Oncology

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“…36, 37 Adipocytes secrete leptin and other adipokines, and leptin concentration is positively correlated with total adipose tissue. 38 Although it can be challenging to separate the effects of leptin from other adipokines, some studies have shown leptin levels to have independent prognostic effects on breast cancer. One study found that leptin levels are positively associated with risk for both pre- and postmenopausal breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese

Rock

Pande

Flatt

et al. 2013

Clinical Breast Cancer

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Background Obesity is associated with increased risk for recurrence and all-cause mortality in breast cancer survivors. Excess adiposity is associated with increased estrogen, insulin, and leptin, and decreased sex hormone binding globulin (SHBG) concentrations, which may promote breast cancer progression and recurrence. This study aimed to assess the effects of weight loss on these factors. Patients and Methods Overweight or obese breast cancer survivors (N = 220) who were enrolled in a weight loss intervention study provided baseline and follow-up blood samples and weight data. Serum estrogens, SHBG, insulin, and leptin were measured at baseline, 6 and 18 months. Results Weight loss of ≥5% of initial weight decreased leptin and insulin compared with those who did not achieve that amount of weight loss (P < .0001). Weight loss also increased SHBG at 6 and 18 months (P < .01). Postmenopausal women who lost ≥5% of body weight at 6 months had lower estrone (P = .02), estradiol (P = .002), and bioavailable estradiol (P = .001) concentrations than women who did not lose at least 5% of body weight, and weight loss at 18 months was significantly related to change in serum bioavailable estradiol concentration (P = 0.02). Conclusion Favorable changes in estrogens, SHBG, insulin, and leptin were observed in association with weight loss in these overweight or obese women who had been diagnosed and treated for breast cancer. Weight loss appears to have favorable effects on hormonal and biological factors associated with increased risk for recurrence and poorer prognosis.

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“…Although the influence of obesity on estrogen availability and hormonal effects on breast cancer prognosis have been considered to be an important component of the interrelationship of obesity and breast cancer [90], adipokines also appear to play a significant role in the progression of malignancies ( Fig. 1) [16,[91][92][93][94].…”

Section: Clinical Studies On Obesity and Disease Progressionmentioning

confidence: 99%

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

Großmann

Ray

Nkhata

et al. 2010

Cancer Metastasis Rev

161

108

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It is well recognized that obesity increases the risk of various cancers, including breast malignancies in postmenopausal women. Furthermore, obesity may adversely affect tumor progression, metastasis, and overall prognosis in both pre- and postmenopausal women with breast cancer. However, the precise mechanism(s) through which obesity acts is/are still elusive and this relationship has been the subject of much investigation and speculation. Recently, adipose tissue and its associated cytokine-like proteins, adipokines, particularly leptin and adiponectin, have been investigated as mediators for the association of obesity with breast cancer. Higher circulating levels of leptin found in obese subjects could be a growth-enhancing factor as supported by in vitro and preclinical studies, whereas low adiponectin levels in obese women may be permissive for leptin's growth-promoting effects. These speculations are supported by in vitro studies which indicate that leptin promotes human breast cancer cell proliferation while adiponectin exhibits anti-proliferative actions. Further, estrogen and its receptors have a definite impact on the response of human breast cancer cell lines to leptin and adiponectin. More in-depth studies are needed to provide additional and precise links between the in vivo development of breast cancer and the balance of adiponectin and leptin.

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Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications

Cited by 95 publications

References 47 publications

An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research

An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research

Favorable Changes in Serum Estrogens and Other Biologic Factors After Weight Loss in Breast Cancer Survivors Who are Overweight or Obese

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

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