Correlation of body mass index to Ghrelin and IGF-1 among children with short stature

Amin, Mona Karem; Ahmed, Heba G.; Selmy, Mohamed; Gad, Suzan

doi:10.1016/j.jped.2021.04.012

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…According to Amin et al (18), in short-stature patients (CDGP and FSS) and controls, ghrelin was significantly linked with chronological years, bone age, weight, height, SDS, and BMI. Eleven controls, ages 6.8-14.8, 19 children with FSS, ages 7-15, and 17 children with CDGP, ages 6.5-15, participated in the study.…”

Section: Resultsmentioning

confidence: 99%

Insulin Growth Factor1 and Ghrelin's Relationship with the Nutritional Status of Children with Short Stature

2023

jjoas-n

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Background: Pediatricians often have to deal with problems of short stature, specifically in underdeveloped nations. Changes to total ghrelin (TG) or acylated ghrelin (AG) were thought to alter growth by changes in growth hormone secretion, which in turn could impact the formation of insulin-like growth factor-1 (IGF-1) or through changes in hunger and food consumption. Aim: To boost the upkeep of children with small heights and the results resulting from it. Methods: Between March 2021 and October 2022, a cross-sectional descriptive study was performed at Mahala General Hospital's pediatric endocrine clinic. In this study, 48 participants were enrolled. The patients were split into two groups: group B had children with unexplained short height, while group A contained children deficient in growth hormone. Ghrelin levels, IGF-1 and growth hormone, thyroxine and triiodothyronine, and thyroid stimulating hormone were all measured.Results: There was a statistically significant drop in IGF-1 in group I compared to group II. Additionally, group I had considerably more Ghrelin than group II. GH exhibited a statistically significant difference in its negative correlation with ghrelin and its positive correlation (with IGF1. Conclusion: The relationship between GH and IGF-1 and ghrelin is negative, and the Short Stature group has a lower body mass index (BMI) than the group with a deficiency in growth hormone, which indicates a lower nutritional status. Idiopathic low stature may have ghrelin as a contributing factor in its etiology.

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Section: Resultsmentioning

confidence: 99%

Insulin Growth Factor1 and Ghrelin's Relationship with the Nutritional Status of Children with Short Stature

2023

jjoas-n

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“…However, some studies showed the opposite of our findings (Tunçel et al, 2016). It has been reported that age and obesity may influence ghrelin levels in MDD patients (Amin et al, 2022; Bouillon‐Minois et al, 2021). We speculated that the results might be inconsistent due to heterogeneity in population selection, age, or obesity of the subjects.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis

Zhang,

Dong,

et al. 2024

Asia-Pacific Psychiatry

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BackgroundMajor depressive disorder (MDD) is one of the global burdens of disease, and its pathogenesis remains unclear. An increasing amount of research indicates that ghrelin regulates mood in patients with MDD. Still, current results are inconsistent, and the mechanisms underlying how ghrelin modulates depressive symptoms are inconclusive, especially in first‐episode drug‐naïve MDD patients. Therefore, this study aims to investigate the relationship and potential mechanism between ghrelin and first‐episode drug‐naïve MDD.MethodsNinety first‐episode drug‐naïve MDD patients and 65 healthy controls (HCs) were included. Hamilton Depression Scale (HAMD‐17) as a measure of depressive symptoms. Plasma levels of ghrelin and hypothalamic–pituitary–adrenal axis (HPA‐axis) hormones were measured in all participants.ResultsCompared to HCs, the ghrelin levels were higher in the MDD (p < .001) and still showed significance after covarying for sex, age, and Body Mass Index (BMI). Ghrelin was positively related to corticotropin‐releasing‐hormone (CRH) levels (r = .867, p < .001), adrenocorticotropic hormone (ACTH) levels (r = .830, p < .001), and cortisol levels (r = .902, p < .001) in partial correlation analysis. In addition, there was a positive correlation between HAMD total score and ghrelin levels (r = .240, p = .026). Other than that, the HAMD total score also had a positive correlation with the CRH (r = .333, p = .002) and cortisol (r = .307, p = .004) levels. Further mediation analysis demonstrated that the relationship between ghrelin and HAMD total score was mediated by CRH (ab‐path; β = .4457, 95% CI = 0.0780–1.0253, c‐path; β = .2447, p = .0260, c′‐path; β = −.2009, p = .3427).ConclusionsThese findings revealed that plasma ghrelin provides a pivotal link to depressive symptoms in first‐episode drug‐naive MDD patients. CRH mediated the relationship between ghrelin and HAMD total score. It might provide new insights into understanding the pathogenesis of MDD, contributing to intervention and treatment from this approach.

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“…Ghrelin increases Corticotropin-releasing hormone (CRH) levels, leading to an increase in corticosteroid secretion. CRH negatively impacts ghrelin expression [16]. Ghrelin is hypothesized to be a component of a neuronal network involved in feeding regulation, influencing the appetitive response to food cues and enhancing brain activity in regions in charge of visual processing, attention, and memory connected to food imagery.…”

Section: Serum Ghrelin and Serotonin On Food Restriction After Supple...mentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Background: Nutritional shortages and acute malnutrition are caused by insufficient protein and calorie consumption. With severe short-and longterm morbidity and death, malnutrition is a serious public health concern. In cachectic situations, the peptide ghrelin level raises making people more hungry. Life protein deficiency changes crucial neurotransmitters, including serotonin, and the brain redox status that underlies neurobehavioral expression.Aim: This study aimed to determine whether the combination of Curcuma xanthorrhixa Roxb. and iron supplementation regulates serotonin and ghrelin expression. Methods: This study employed a true experimental posttest-only control group design. The study subjects were 25 male Wistar rats divided into five groups. Curcuma xanthorrhiza Roxb. Rhizome extract at 80 mg/kg BW/day and elemental iron at 0.054 mg/kg BW/day were administered orally for 14 days after malnutrition induction. The differences between the groups before and after the completion of study interventions were calculated. Results: Curcuma xanthorrhiza Roxb. rhizome extract groups with elemental iron and combinations did not differ significantly in ghrelin levels. (p=0.88, Kruskal-Wallis H test). Serotonin levels did not differ between the groups (p=0.84, Kruskal-Wallis H test). Conclusion: Elemental iron, Curcuma xanthorrhiza Roxb., and the combination treatment did not alter the expression of serotonin or ghrelin. More studies are required on the effects of Curcuma xanthorrhiza Roxb., elemental iron, and a combination of these factors to reverse the effects of malnutrition. Further research is required to utilize higher macronutrient diets and supplements after malnutrition induction.

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Correlation of body mass index to Ghrelin and IGF-1 among children with short stature

Cited by 4 publications

References 29 publications

Insulin Growth Factor1 and Ghrelin's Relationship with the Nutritional Status of Children with Short Stature

Insulin Growth Factor1 and Ghrelin's Relationship with the Nutritional Status of Children with Short Stature

Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis

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