Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors

Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer

“…Silencing CENPF can decrease the ability of HCC cells to proliferate, form colonies and induce tumor formation in nude mice (18). In the present study, using clinical samples, we also found that the expression of CENPF in PCa tissues was significantly higher than that in non-cancerous prostate tissues, which was consistent with the results of previous studies on other tumor types (17)(18)(19)(20)(21)(22)(23). However, we failed to find any correlation of CENPF with the clinicopathological characteristics of the patients with PCa with limited information.…”

“…The results of previous studies have demonstrated that CENPF may play a role in the regulation of cell division and may be used as proliferation marker of malignant cell growth in clinical practice due its localizations in the cell cycle (13)(14)(15)(16). Accumulating evidence has demonstrated the involvement of CENPF in various types of human cancer, such as breast cancer (17), hepatocellular carcinoma (18), colorectal gastrointestinal stromal tumors (19), nasopharyngeal carcinoma (20), non-Hodgkin's lymphoma (21), salivary gland tumors (22) and neuroblastic tumors (23). The overexpression of CENPF has also been reported to be associated with a poor prognosis in hepatocellular carcinoma, breast cancer, colorectal gastrointestinal stromal tumors and nasopharyngeal carcinoma (17)(18)(19)(20).…”

Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors

“…CENP-F plays several important roles in mitotic events, including centromere/kinetochore maturation, chromosome alignment and segregation, and anaphase spindle stabilization (36). We have already reported that human CENP-F mRNA is closely linked to the increased or abnormal cell proliferation in salivary gland carcinomas (37). The increased expression of Bub1 and CENP-F gene might cause cell cycle progression and high proliferative activity in malignant conditions.…”

Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

“…The high level expression then persists till anaphase [1][2][3]. Such a property makes mitosin/ CENP-F a useful proliferation marker in cancer research [8][9][10][11]. Inside cells, mitosin is transiently associated with the outer kinetochore plate and the spindle apparatus in early M phase and is redistributed to the spindle midzone in anaphase and to the midbody in telophase, followed by complete degradation at the end of cell division [1][2][3]12].…”