Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

Abstract

Background A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behçet’s disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behçet’s Disease Dynamic Activity Measurement (IBDDAM). Methods This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded. Blood samples were then obtained and the relationships between their disease status and manifestations and their laboratory parameters were evaluated with statistical models to find possible correlations. Results Our analysis showed a significantly higher RDW in patients with BD who had ocular manifestations (p < 0.001) and oral aphthae (p = 0.004). Patients with active BD had higher RDW (p < 0.001) and MPV (p < 0.001) in comparison to those with currently inactive BD. Similarly, patients who had any type of ocular manifestation had higher RDW (p < 0.001) and MPV (p < 0.001). Regression analyses identified a statistically significant model for the effect of RDW and MPV in predicting active BD status (p < 0.001), as well as its significant relationship with active ocular manifestations (p < 0.001). Conclusion BD was found to be associated with an increase in MPV and RDW, particularly during active phases. RDW and MPV were also found to have predictive value for screening to detect BD activity and its ocular complications.

Relationship Between C-Reactive Protein/Serum Albumin Ratio, Neutrophil/Lymphocyte Ratio, and ANCA-Associated Vasculitis Activity: A Retrospective Single Center Cohort Study

“…Moreover, a high C-reactive protein (CRP)/albumin (ALB) ratio (CAR) was found to be associated with poor outcome of cancer patients, and this marker could be used as a predictor of poor cancer prognosis (8). To date, many extensive studies have been conducted on the effects and use of NLR, CAR, and mean platelet volume (MPV) in disease progression and prognosis, such as psoriasis, rheumatoid arthritis, systemic lupus erythematosus, Behçet's syndrome, and Sjögren syndrome (7,(9)(10)(11)(12). However, there are very few studies on the significance of these markers in AAV.…”

The effect of colchicine treatment on complete blood cell count-based parameters in patients with Behçet's disease

“…An increased MPV has been associated with an increased thrombotic disposition (26,27). A higher MPV in patients with active BD has also been reported (28). Ataş et al (11) evaluated the effect of colchicine on MPV levels, and after colchicine treatment, a decrease in MPV was obtained in their study.…”

Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study

“…The possible explanation is that inflammation might lower erythrocyte survival and, in fact, promote anisocytosis, causing immature erythrocytes in larger volumes to enter the blood flow and an increased RDW [ 23 , 24 ]. In Behcet's disease (BD), a chronic systemic inflammatory disease, Masoumi et al discovered RDW levels were significantly higher in BD patients with any ocular manifestations and increased RDW level was significantly correlated with the risk of developing ocular diseases in BD patients (OR = 2.031, 95% CI: 1.572–2.625; p < 0.001), suggesting that elevated RDW may be related to the ocular vascular inflammation [ 25 ]. Aksoy et al also found an association between RDW and BD ocular activity, supporting the results of Masoumi et al [ 26 ].…”