2021
DOI: 10.1016/j.bbr.2021.113165
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Correlation of distinct behaviors to the modified expression of cerebral Shank1,3 and BDNF in two autistic animal models

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Cited by 16 publications
(7 citation statements)
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“…This is in parallel with other studies using PPA treatment, which also report social impairment measured more than four weeks after the initial PPA treatment [22,[49][50][51]. PPA animals also exhibited an increased immobility time compared to the control animals (Figure 2C), which might indicate an increased anxiety-like behavior, which is a behavioral feature of ASD models [27,49]. However, validated tests of anxiety need to be performed in future studies to better assess anxiety-like behavior in this model of autism.…”
Section: Discussionsupporting
confidence: 89%
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“…This is in parallel with other studies using PPA treatment, which also report social impairment measured more than four weeks after the initial PPA treatment [22,[49][50][51]. PPA animals also exhibited an increased immobility time compared to the control animals (Figure 2C), which might indicate an increased anxiety-like behavior, which is a behavioral feature of ASD models [27,49]. However, validated tests of anxiety need to be performed in future studies to better assess anxiety-like behavior in this model of autism.…”
Section: Discussionsupporting
confidence: 89%
“…In addition, several clinical studies have reported significantly higher levels of BDNF in the serum of autistic individuals [26]. However, others using the subcutaneous injection of PPA in rats have reported a significant reduction in the protein levels of BDNF in the hippocampus in juvenile animals [27]. Interestingly, a study using a transgenic model of autism (Shank1 knock-out) reported an increase in Bdnf transcript levels in Shank1 knock-out animals only after an object recognition task and not at baseline, and levels were negatively correlated with object recognition memory [87].…”
Section: Discussionmentioning
confidence: 99%
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“…However, the decreased sociability and social preference indices observed in VPA mice, compared to control mice, suggested an impairment of their sociability and social preference, similar to previous observations (19,20). Moreover, the results from the self-grooming, open field, and light-dark tests showed that VPA mice exhibited more anxiety-like and stereotypic behaviors than control mice, which was consistent with previous studies (19,31,34). The autistic-like behaviors of VPA mice indicated the successful establishment of the VPA-treated ASD mouse model.…”
Section: Discussionsupporting
confidence: 91%
“…Furthermore, expression levels of BDNF, proBDNF, and its intrinsic receptor, TrkB, are reduced in the cerebella of patients with neuropsychiatric disorders, including schizophrenia, bipolar disorder (BPD), and major depressive disorder (MDD) as well as in a rodent model for ASD (Soontornniyomkij et al, 2011;Yang et al, 2017;Alò et al, 2021). Additionally, CAPS2-deficient mice that show reduced secretion of BDNF from CGNs exhibit developmental deficits around the cerebellar vermis, such as increased CGN apoptosis and impaired PC dendritogenesis.…”
Section: Bdnf In Cerebellar-related Neurodevelopmental Disordersmentioning
confidence: 99%