Correlation of high sensitive C-reactive protein and Hepatitis C Virus RNA in anti-HCV-positive sera

Abstract

ÖZET Amaç: HCV antikoruna sahip kişilerden elde edilen se-rumlarda HCV RNA'nın pozitif ve negatifliğine göre ka-raciğerden salgılanan hsCRP düzeyinin farklılık belirlen-mesidir. Gereç ve yöntem: Klinik olarak Hepatit-C şüpheli olup anti-HCV'si pozitif tespıt edilen toplam 84 hasta çalışma-ya dahil edildi. Anti HCV'si pozitif 84 örnek, HCV RNA sonuçlarına göre; HCV RNA'sı pozitif grup (Grup 1, 50 örnek) ve HCV RNA'sı negatif grup (Grup 2, 34 örnek) olmak üzere iki gruba ayrıldı. Bulgular: HCV'si pozitif 84 örneğinin 50'sinde HCV RNA pozitif (Grup 1), 34'ünde HCV RNA negatif (Grup 2) ola-rak tespit edildi. 1.grupta 50 serum örneğinin 11'de (%22), 2.grupta 34 serum örneğinin 3'de (%8.8) hsCRP değer-leri normal değerin üzerinde tespit edildi. Sonuç: Örneklerin sayısal olarak karşılaştırıldığında Grup 1 lehine istatistiksel olarak anlamlı bulundu (p<0,001). Buna karşılık iki gruptan elde edilen hsCRP değerlerinin kantitatif ortalamalarının karşılaştırılmasında elde edilen sonuçlar istatistiki olarak anlamsız bulundu (P>0.05). Anahtar kelimeler: HCV, hsCRP, ilişki ABSTRACT Objectives: To determine whether the level of high sensitive C-reactive protein (hsCRP) secreted from liver differed according to the positivity and negativity of the HCV RNA in sera collected from individuals with HCV antibod-ies. Materials and methods: A total of 84 patients with clinically suspected Hepatitis C were included in this study, in which anti-HCV was detected to be positive. Eighty four anti-HCV positive samples were divided into two groups according to the HCV RNA results, as the HCV RNA positive group (Group 1, 50 samples) and the HCV RNA negative group (Group 2, 34 samples). Results: 50 of the 84 samples with anti HCV positivity were detected to be positive for HCV RNA (Group 1), whereas 30 were detected as negative (Group 2). While the hsCRP values were found to be above the normal level in 11 (22%) of the 50 sera samples in the first group, and in 3 (8,8%) of the 34 sera samples in the second group. Conclusion: Numerical comparison of the hsCRP positive samples revealed a statistically significant result in favor of group 1 (p<0,001). On the other hand, results obtained from comparison of the quantitative hsCRP mean values obtained from the two groups were found to be statistically insignificant (P>0.05).

Prediction of Coronary Artery Disease Among Chronic Hepatitis C Virus Infected Patients in Tamilnadu, India

“…During the literature collection for our study, the interesting point is that similar results observed in a couple of sepa rate studies in haemodialysis patients. In both stud ies, the higher level of CRP values are detected in the hepatitis C antibody negative group when compared with the group have positive condition for the same hepatitis C antibody 13,2 . Romania in 1995, reported that the earlier results are associated with the subjects of CRP level.…”

Anti HCV seropozitif kişilerde moleküler HCV RNA test sonuçlarının değerlendirilmesi

“…[14][15][16][17][18][19][20] Kendal ve ark [21] Güneydo¤u Anadolu bölge-sinde yapt›klar› bir araflt›rmada, anti-HCV pozitif hastalar›n %56's›nda HCV-RNA testini pozitif bulmufllard›r. Bu oran bizim araflt›rmam›zdaki sonuçlara göre daha dü-flük düzeydedir.…”