Correlation of Human Age-Related Cataract with Some Blood Biochemistry Constituents

Abstract

Purpose: The causes of age-related cataract are multifactorial and particular consideration has been given to the role of nutritional factors in cataract formation. The purpose of this study was to determine the levels of certain blood biochemistry constituents in cataract patients and controls and evaluate their potential, if any, as identifying risk factors in cataractogenesis. Methods: This is a case-control study where 155 cataract patients and 155 matched controls were chosen for evaluation. Cataract subjects were further divided into subgroups depending on the location of the cataract. All underwent routine eye examinations and blood samples were taken from each one for blood biochemistry analysis including serum levels of glucose, urea, cholesterol, triglycerides, total protein, albumin, bilirubin, calcium, sodium and potassium and the enzymes aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Results: Mean levels of total protein, bilirubin, calcium, sodium, alanine aminotransferase and alkaline phosphatase differed significantly between patient and control groups. Patients with posterior subcapsular cataract had significantly higher glucose levels (p = 0.05) compared with patients with other types of cataract. It was also found that those patients with a cortical cataract had the highest level of urea, differing significantly from other subgroups and controls. Conclusions: The mean levels of all constituents under study fell within normal body range. However, the levels of several important factors demonstrated a positive and significant correlation with cataract. While we do not presume to present these results as conclusive, it is possible that a gradual and constant variation in these parameters may be predisposing factors in cataractogenesis.

Correlation of Cataract with Serum Lipids, Glucose and Antioxidant Activities: A Case-control Study

“…Diabetes was also a predictor for the development of nuclear cataract, and newly diagnosed diabetes predicted the development of PSC. This result is similar to that of an Iranian study on 155 age-and sex-matched pairs in which PSC patients had significantly higher glucose levels than with other types of cataract (16). These findings highlight the harmful effect of glucose on lens which has been previously indicated in research showing the relationship of diabetes and cataract (17,18).…”

Assessment of Aqueous Humor Zinc Status in Human Age-Related Cataract

“…Patients with systemic problems such as diabetes, hypertension and hyperlipidemia were excluded from the study. Each individual underwent thorough physical and ocular evaluations as previously described [11] . The patients were divided into four sub-groups according to type of cataract [(1) nuclear plus cortical, n = 13; (2) nuclear plus cortical plus posterior subcapsular, n = 25; (3) cortical, n = 1; (4) posterior subcapsular, n = 5].…”

Estimation of serum calcium and phosphorus levels in male cataract patients: A case control study

“…Our findings indicate that serum calcium and phosphorus levels in cataract patients vary. This variation could be due to regional differences & also the Dietary factors which vary across the different parts of the world.Studies conducted by the Mansour Mirsamadi, Issa Nourmohammadi in Iran (2003) suggested that increased serum calcium levels in patients diagnosed with the cataract are the predisposing factors for the cataractogenesis15 . Statistically significant decreased serum calcium & phosphorus was found in our study compared to SmitaA Deokar et.al.…”