Correlation of LAPTM4B polymorphisms with cervical carcinoma

Abstract

BACKGROUND: Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, is overexpressed in several carcinomas. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. The purpose of this study was to investigate the association between different LAPTM4B alleles and the risk of cervical carcinoma. METHODS: A case-control analysis was performed in 317 patients with cervical cancer and 416 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction. Odds ratios and 95% confidence intervals (CIs) were computed using an unconditional logistic regression model. RESULTS: There was a significant difference (P<.001) in LAPTM4B*2 allele frequency between cervical cancer cases (35.8%) and controls (26.3%). There was also a significant difference in the overall genotypic distribution between patients and controls (P < .001). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was associated with a significantly increased risk of cervical cancer, with adjusted odds ratios of 1.60 (95% CI, 1.15-2.22) and 2.12 (95% CI, 1.20-3.76) for the *1/2 and *2/2 genotype, respectively. Stratification analysis indicated that the association was more pronounced in younger subjects, smokers, premenopausal women, and women with more parities. Moreover, multiplicative joint effects were found between the *1/2 or *2/2 genotype and smoking. CONCLUSIONS: The findings of this study indicated that the LAPTM4B*2 allele might be a cervical cancer risk factor and may play an important role in genetic susceptibility to cervical cancer in the Chinese population.

LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis

“…Thirteen of the 17 eligible studies were HB studies and the remaining four were PB studies. The studies focused on the following cancer types: four liver cancer [15-18]; two lung cancer [19,20]; two breast cancer [21,22]; one cervical carcinoma [23]; one colon, rectal, and oesophageal cancers [24]; one gallbladder carcinoma [25]; one gastric cancer [26]; one nasopharyngeal carcinoma [27]; one ovarian cancer [28]; one pancreatic cancer [29]; one lymphoma [30]; and one endometrial carcinoma [31]. All of the patients were confirmed by histopathologic examination.…”

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

“…Previous studies indicated that LAPTM4B polymorphism was associated with susceptibility to liver cancer, 26,33 gall bladder carcinoma 26 cervical carcinoma, 34 gastric cancer, 27 breast cancer, 24,25 colon cancer, 28 endometrial carcinoma, 20 and ovarian cancer.…”

Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients

“…Previous studies showed that LAPTM4B *2 allele was associated with increased susceptibility of lung cancer [20], gastric cancer [21], colorectal cancers [22], lymphoma [26], cervical cancer [23] and breast cancer [24]. The risk of developing these cancers were increased to 1.720, 1.710, 1.512, 1.610, 1.490, and 1.301 fold in individuals carrying allele *2 in comparison with *1, respectively.…”

“…Allele*1 differs from allele*2 in that it contains only one copy of a 19-bp sequence in the first exon, whereas this sequence is duplicated and tandemly arranged in allele*2 (Figure 1). Previous studies showed that the LAPTM4B *2/2-type allele was significantly associated with the susceptibility of adenocarcinoma including lung cancer [20], gastric cancer [21], colorectal cancers [22], cervical cancer [23] and breast cancer [24], but not in squamous cell carcinoma such as esophageal carcinoma, rectum carcinoma [22], and nasopharyngeal carcinoma[25]. However, the origin of melanocytes is unique: derived from the neural crest cells.…”