Correlation of Intraocular Pressure with Central Corneal Thickness in Premature and Full-Term Newborns

Karahan, Eyyüp; Zengin, Mehmet Özgür; Tuncer, İbrahim; Zengın, Neslihan

doi:10.5301/ejo.5000494

Cited by 14 publications

(16 citation statements)

References 18 publications

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“…In Muslubas’ cohort, CCT changed with birth weight and gestational age. [5] However, Karahan et al [8] found that CCT did not correlate with gestational age or birth weight in their cross-sectional study. The CCT in Sekeroglu et al [13] was negatively correlated with gestational age and birth weight.…”

Section: Discussionmentioning

confidence: 95%

“…Changes in corneal thickness and corneal diameter in premature infants have been observed to occur. [3–8]…”

Section: Introductionmentioning

confidence: 99%

“…In other studies, a significant change in CCT from preterm to term has been found. [5–8] Further, CCT readings obtained from these studies have varied. This difference in average CCT results may be in part due to the variable instrumentation used in the studies; difficulties in obtaining measurements from infants and possibly racial differences and perinatal factors such as ventilation.…”

Section: Introductionmentioning

confidence: 99%

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Central corneal thickness changes and horizontal corneal diameter in premature infants

et al. 2018

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To report observations of horizontal corneal diameter (HCD) and central corneal thickness (CCT) changes in premature infants with stable optic disc cupping and intraocular pressures (IOPs). The HCD and CCT at term serve as a baseline for premature infants.Sixty-three premature infants were enrolled in a prospective case series. HCD, CCT, and IOP were measured. RetCam images of the optic discs were used to evaluate the cup-disc ratio (CDR) and read by an independent masked observer. Data were collected at between preterm (32–36 weeks) and again at term (37–41 weeks) postconceptual age. Left eye measurements were used for statistical analysis. Left eye findings were combined to construct predictive models for HCD and CCT.The mean HCD was 9.1 mm (standard deviation [SD] = 0.7 mm) at preterm and 10.0 mm (SD = 0.52 mm) at term. The mean CCT preterm was 618.8 (SD = 72.9) μm and at term 563.9 (SD = 50.7) μm, respectively. The average preterm CDR was 0.31 and at maturity was 0.33. Average IOP of preterm and term was 13.1 and 14.11 mm Hg, respectively. There was significant linear correlation between HCD with the postmenstrual age (r = 0.40, P < .01) and the head circumference (r = 0.33, P < .05). Predictive models were constructed for HCD (R2 = 0.52, 0.2 mm/wk) and CCT (R2 = 0.23, −11.4 μm/wk) with postconceptual ages.The HCD and CCT variation did not affect IOP reading over time. CCT was not correlated with birth parameters and decreased as the infant reached term. Corneal diameter correlated with gestational age at birth and head circumference.

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Section: Discussionmentioning

confidence: 95%

“…Changes in corneal thickness and corneal diameter in premature infants have been observed to occur. [3–8]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Central corneal thickness changes and horizontal corneal diameter in premature infants

et al. 2018

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“…There are also variable CCT and IOP values of premature infants at the literature [5,7,[9][10][11] The reported differences can be due to timing of evaluation and variable postconceptional ages of infants during measurement. Contrary to aforementioned studies, Muslubas et al [12] found that premature infants have slightly thicker corneas but similar IOP measurements when compared to term neonates.…”

Section: Discussionmentioning

confidence: 99%

Central corneal thickness and intraocular pressure in premature infants

Şekeroğlu¹,

Hekimoğlu

Petriçli

et al. 2015

Int Ophthalmol

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To evaluate the central corneal thickness (CCT) and intraocular pressure (IOP) of premature infants and to document correlation of them with gestational age, chronological age, and birth weight of infants. Using a hand-held applanation tonometer and a portable pachymeter, IOP and CCT of 170 premature infants were measured just before initial retinopathy of prematurity screening examination and re-measured 4 weeks after the first visit. The CCT and IOP were positively correlated during the first (r = 0.616, p < 0.001) and second (r = 0.564, p < 0.001) visits. The mean CCT at first and second visits were 568.1 ± 22.1 (527-628) and 561.6 ± 21.4 (520-619) µm, consecutively (p < 0.001). Gestational age, chronological age and birth weight of infants were found to be negatively correlated with CCT at first (r = -0.751, p < 0.001; r = -0.745, p < 0.001; r = -0.581, p < 0.001, consecutively) and second (r = -0.729, p < 0.001; r = -0.729, p < 0.001; r = -0.555, p < 0.001, consecutively) visits. The mean IOP at first and second visits were 14.1 ± 1.9 (11-19) and 13.7 ± 1.7 (11-18) mmHg, consecutively (p < 0.001). Gestational age, chronological age, and birth weight of infants were found to be negatively correlated with IOP at first (r = -0.724, p < 0.001; r = -0.715, p < 0.001; r = -0.558, p < 0.001, consecutively) and second (r = -0.704, p < 0.001; r = -0.703, p < 0.001; r = -0.518, p < 0.001, consecutively) visits. CCT and IOP of the premature infants with a smaller gestational age were found to be higher (p < 0.001 for both). Premature infants with smaller gestational age have higher CCT and IOP values when compared to older infants. These values tend to become lower 4 weeks after the first examination as infants become older. The CCT and IOP were positively correlated with each other and both were negatively correlated with gestational age, chronological age, and birth weight during first and second visits.

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“…Gunay observed a negative correlation between GA, BW, and CCT in premature infants and demonstrated that GA and BW could significantly predict the CCT values [ 11 ]. However, Karahan et al showed that CCT did not correlate with GA or BW in their cross-sectional study [ 8 ]. Figure 3 in our study showed that the CCT of low BW (≤1500 g) was thicker than high BW (>1500 g).…”

Section: Discussionmentioning

confidence: 99%

Measurement and Analysis of Central Corneal Thickness at Different Postnatal Stages in Chinese Premature Infants

Liu

Lao

et al. 2020

Journal of Ophthalmology

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Purpose. The objective of this study was to evaluate central corneal thickness (CCT) in Chinese premature infants at different postnatal stages to study the peak point and analyze influential factors on CCT development. Methods. This was a cross-sectional study of premature infants. Initial CCT measurement was taken at 34 weeks of gestational age (GA) and at intervals until 88 weeks of postmenstrual age (PMA) was reached. The comparison and correlation analysis were carried out to access the association of CCT with gender, birth weight (BW), GA, and retinopathy of prematurity (ROP) for each PMA. The premature infants were divided into the thick CCT group and the thin CCT group according to the average CCT at 40 w. And the difference in CCT between the two groups at subsequent 52 w and 64 w was compared. Results. A total of 1726 premature infants (3463 measurements) with an average of 2.21 ± 1.57 measurements were included in this study. The CCT decreased from 34 w GA to 52 w PMA (R = 92.36, P<0.0001) and then reached a plateau (R = 2.541, P=0.3567). Male P<0.05, low BW P<0.05, and low GA P<0.05 were associated with thicker CCT at the early stage of PMA. The premature infants who had thick CCT at 40 w would have thick CCT at 52 w and 64 w accordingly. Conclusions. The CCT values of premature infants decreased over time and plateaued at 52 w PMA. Gender, BW, and GA were considered as the influential factors of CCT at the early stage of PMA. Moreover, CCT at 40 w could forecast its development trend at 52 w or 64 w after birth.

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Correlation of Intraocular Pressure with Central Corneal Thickness in Premature and Full-Term Newborns

Abstract: Our results showed that the CCT does not affect IOP significantly in preterm infants. More prospective studies are needed for determining the effect of CCT and other ocular and systemic factors on IOP in preterm infants.

Cited by 14 publications

References 18 publications

Central corneal thickness changes and horizontal corneal diameter in premature infants

Central corneal thickness changes and horizontal corneal diameter in premature infants

Central corneal thickness and intraocular pressure in premature infants

Measurement and Analysis of Central Corneal Thickness at Different Postnatal Stages in Chinese Premature Infants

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