Correlation of IOP with Corneal Acoustic Impedance in Porcine Eye Model

Zhang, Jun; Zhang, Yi; Li, Yang; Chen, Ruimin; Shung, K. Kirk; Richter, Grace M.; Zhou, Qifa

doi:10.1155/2017/2959717

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Thus, we mimicked different IOP models with increasing CCTs using 3Dprinted eye models. Almost all previous reports used ex vivo porcine eyeballs by changing the height of saline bottles to evaluate the elevated IOP [7,8]. Our model might be a promising alternative to the conventional porcine eye model.…”

Section: Discussionmentioning

confidence: 98%

“…Generally, the central corneal thickness (CCT) significantly affects IOP readings obtained by tonometry [6]. Previous studies have induced a higher IOP model by changing the height of a drip stand in porcine eyes [7,8], but this technique is limited to a wet laboratory curriculum. To simplify the simulation of the elevated IOP model, we developed artificial eye models by changing the CCT based on a 3D printing approach.…”

Section: Introductionmentioning

confidence: 99%

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3D-printed eye model: Simulation of intraocular pressure

Kobashi¹,

Kobayashi²

2023

PLoS ONE

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Purpose To develop artificial eye models using 3D printing and to evaluate the correlation between different corneal thicknesses and intraocular pressures (IOPs). Methods We designed 7 artificial eye models using a computer-aided design system and fabricated them using 3D printing. Corneal curvature and axial length were based on the Gullstrand eye model. Hydrogels were injected into the vitreous cavity, and seven different corneal thicknesses (200 to 800 μm) were prepared. In this proposed design, we also produced different corneal stiffnesses. A Tono-Pen AVIA tonometer was used by the same examiner to perform five consecutive IOP measurements in each eye model. Results Different eye models were ideally created using 3D printing. IOP measurements were successfully performed in each eye model. The corneal thickness was significantly correlated with IOP (R2 = 0.927; 𝑃<0.001). Conclusion The 3D-printed eye model is useful for evaluating IOP measurements. This technique might be a promising alternative to the conventional porcine eye model.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

3D-printed eye model: Simulation of intraocular pressure

Kobashi¹,

Kobayashi²

2023

PLoS ONE

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“…Based on Pascal's principle of fluid mechanics, the pressure produced by fluid in an enclosed system will be proportional to the difference of height between the fluid surface and the target site. By changing the height of drip bag in terms of water pressure which directly increased IOP of the porcine eye, thus enabling a precise control of IOP in the experiments 21 …”

Section: Methodsmentioning

confidence: 99%

A systematic approach to reduce intraocular pressure for the treatment of glaucoma

Hsu

Huang

et al. 2022

Biotechnology Progress

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Glaucoma is the leading cause of irreversible blindness due to increased intraocular pressure (IOP) in the eye. We have developed a novel treatment option for glaucoma based on a real-time IOP-dependent nitric oxide synthase (NOS) and packed in a therapeutic contact lens to reduce the IOP. First, 1.6 nmole nitric oxide was produced from the genetic chassis, which was optimized for isopropyl β-d-1-thiogalactopyranoside (IPTG) induction in a T7 expression system. For biosafety concerns to human being, the csgAD genes responsible for curli biofilm formation in Escherichia coli were co-expressed with NOS in the designated NOSAD strain to strengthen the adherence of cells to the contact lens, thereby preventing the contamination into the eyes. Moreover, NOSAD is a diaminopimelic acid (DAP) auxotrophic strain, which cannot survive without supplementation of DAP and reached the critical consideration of biosafety to the environment. We also demonstrated that the nitric oxide diffusion was 3.6-times enhanced from penetration into the aqueous humor of porcine eyes. The deformation ratio of the contact lens was correlated to the change of IOP by using a digital image correlation (DIC) system in a porcine eye model. The novel systematic approach provides an alternative treatment for glaucoma patients in the future.

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“…The exploration of vibroacoustic properties as a means to ascertain pressure has been a focus of recent studies. Research has utilized less invasive acoustic wave vibrations to infer the biomechanical properties of the eye [ 22 , 23 , 24 , 25 , 26 ], finding correlations between IOP and parameters like corneal acoustic impedance [ 27 ], corneal wave speed [ 28 , 29 ], ocular resonance frequency [ 30 , 31 ], and vibration damping characteristics [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Feasibility of Estimating Intraocular Pressure Using Vibrational Response of the Eye: A Methodological Approach

Jeon,

Toh,

Park

et al. 2024

Sensors

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This study addresses the limitations of current tonometry techniques by exploring vibroacoustic properties for estimating intraocular pressure (IOP), a key diagnostic parameter for monitoring glaucoma—a significant risk factor for vision loss. Utilizing vivo porcine eyeballs, we investigated the relationship between IOP and the nonlinear vibration transfer function ratio (NVTFR). Through applying varying vibration levels and analyzing responses with transfer function analysis and univariate regression, we identified a strong negative correlation between NVTFR and IOP, evidenced by a Pearson correlation coefficient of −0.8111 and significant results from generalized linear model (GLM) regression (p-value < 0.001). These findings indicate the potential of NVTFR as a vital indicator of IOP changes. Our study highlights the feasibility of using vibroacoustic properties, specifically NVTFR, to measure IOP. While further refinement is necessary for in vivo application, this approach opens new possibilities for non-invasive and patient-friendly IOP monitoring, potentially enhancing ophthalmology diagnostic techniques and providing a foundation for future research and development in this critical area.

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Correlation of IOP with Corneal Acoustic Impedance in Porcine Eye Model

Cited by 4 publications

References 33 publications

3D-printed eye model: Simulation of intraocular pressure

3D-printed eye model: Simulation of intraocular pressure

A systematic approach to reduce intraocular pressure for the treatment of glaucoma

Exploring the Feasibility of Estimating Intraocular Pressure Using Vibrational Response of the Eye: A Methodological Approach

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