Correlation of Leptin With Acute Myocardial Infarction: A Case Control Study

Syed, Asghar Hussain; Lohana, Sameer; Aung, Norah; Memon, Muhammad Qasim; Shaikh, Anam; Memon, Sidra; Hassan, Syeda Maria; Kumar, Besham

doi:10.7759/cureus.12190

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…The present conclusions have clinical importance because an elevated leptin level could be a risk factor for the development of cardiovascular disease in adults with OSAS ( 47 ). It is crucial to understand the mechanism which drive these changes in leptin levels because leptin has been reported to be related with an increased risk of myocardial infarction, hemorrhagic stroke, abnormal fibrinolysis in men and postmenopausal women ( 48 – 50 ) . These disorders are also typical complications among OSA patients.…”

Section: Discussionmentioning

confidence: 99%

“…Second, hypoxia is the most important pathophysiological change in patients with OSAS ( 63 ). As AHI increases, oxygen saturation decreases significantly at night and hypoxemia occurs, which causes activation of the sympathetic nervous system, elevated angiotensin levels, and blood pressure fluctuations, all of which can lead to increased plasma leptin levels ( 48 , 64 ). In patients with OSA, repetitive apnea episodes aggravate the hypoxemia and CO 2 retention, both of which augment sympathetic activity and reduce parasympathetic activity ( 48 , 64 ).…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

2021

Front. Endocrinol.

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BackgroundObstructive sleep apnea syndrome (OSAS) is associated with various adipokines. Leptin, a common adipokine, has attracted considerable attention of many researchers in recent years. So far, there has been little agreement on whether blood leptin levels differ in patients with OSAS. Thus, this meta-analysis examined the relationship between serum/plasma leptin levels and the occurrence of OSAS.MethodWanFang, Embase, CNKI, Medline, SinoMed, Web of Science, and PubMed were searched for articles before March 30, 2021, with no language limitations. STATA version 11.0 and R software version 3.6.1 were used to analyze the obtained data. The weighted mean difference and correlation coefficients were used as the main effect sizes with a random-effects model and a fixed-effects model, respectively. Trial sequential analysis was conducted using dedicated software.ResultScreening of 34 publications identified 45 studies that met the inclusion criteria of this meta-analysis and meta-regression. Our results suggested that plasma/serum leptin levels were remarkably higher in individuals with OSAS than in healthy individuals. Subgroup analyses were performed based on OSAS severity, ethnicity, age, body mass index, assay type, and sample source. The serum and plasma leptin levels were increased in nearly all OSAS subgroups compared to those in the corresponding control groups. Meta-regression analysis indicated that age, BMI, severity, assay approaches, study design, PSG type and ethnicity did not have independent effect on leptin levels. Furthermore, a positive relationship between the serum/plasma leptin level and apnea-hypopnea index (AHI) was found in the meta-analysis. The results of the trial sequential analysis suggested that the enrolled studies surpassed the required information size, confirming that our study findings were reliable.ConclusionOur study results demonstrate that OSAS patients have higher leptin levels in serum/plasma compared to controls, and the serum/plasma leptin level is positively correlated with AHI, especially in adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

2021

Front. Endocrinol.

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“…High levels of leptin in the blood (hyperleptinemia) and low levels of the hormone adiponectin are often seen in patients with obesity (11,12). Serum levels of leptin and resistin increase in cardiovascular events such as AMI and are therefore considered modifiable risk factors for AMI (13)(14)(15). In clinical studies, the connection between coronary heart disease (CHD) severity and serum resistin levels has received considerable attention.…”

Section: Association Of Serum Leptin and Resistin Levels Among Obese ...mentioning

confidence: 99%

Association of serum leptin and resistin levels among obese Saudi patients with acute myocardial infarction in Asir region

Ayed A. Dera,

Bashayr Algamdi,

Irfan Ahmad

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…What was not observed with short-term administration of leptin [ 13 , 14 , 15 , 16 ]. In contrast, clinical data suggest that the blood leptin levels are correlated with cardiovascular morbidity, obesity, MI, and heart failure [ 2 , 17 , 18 , 19 ]. Moreover, hyperleptinemia is often considered a surrogate marker of cardiovascular diseases [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury

Polyakova

Mikhaylov

Галагудза

et al. 2021

Heliyon

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Aim Hyperleptinemia potentiates the effects of many atherogenic factors, such as inflammation, platelet aggregation, migration, hypertrophy, proliferation of vascular smooth muscle cells, and endothelial cell dysfunction. The present study analysed the effects of long-term hyperleptinemia in an in vivo myocardial ischemia-reperfusion model to demonstrate whether the in vivo deleterious effect also affects cardiac structure and function. Main methods Rats were subcutaneously administered leptin for 8 days to estimate the involvement of the JAK/STAT pathway. Data from 58 male Wistar rats were included in the final analysis. Myocardial infarction (MI) was modelled by the 30-minute ligation of the main left coronary artery followed by 120-minute reperfusion. Hemodynamic measurements, electrocardiography monitoring, echocardiography, myocardial infarct size and area at risk, blood biochemical parameters, leptin, IL-6, TNF-alpha, FGF-21, and cardiomyocyte morphology were measured. The expression of JAK2, p-JAK2, STAT3, p-STAT3 was assessed by Western Blot analysis. Statistical analyses were performed using IBM SPSS Statistics v.26. Key findings Eight-day hyperleptinemia in rats leads to an increase in blood pressure and heart rate, myocardial hypertrophy, impaired LV function, the frequency of ischemic arrhythmias, dyslipidemia, systemic inflammation, and the size of induced myocardial infarction. Significance: The blockade of the JAK/STAT signalling pathway effectively reverses the negative effects of leptin, including increased blood pressure and total cholesterol.

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Correlation of Leptin With Acute Myocardial Infarction: A Case Control Study

Cited by 4 publications

References 22 publications

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Association of serum leptin and resistin levels among obese Saudi patients with acute myocardial infarction in Asir region

Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury

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