Correlation of Lipid Peroxidation Index With Sickle Haemoglobin Concentrations In Malaria-Positive and-Negative Statuses of AA, AS and SS Individuals from the University of Nigeria, Nsukka Community

Uzoegwu, Peter N.; Onwurah, AE

doi:10.4314/br.v1i1.28523

Cited by 7 publications

(8 citation statements)

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“…Numerically, more males than females were infected despite the fact that more females than males were examined in the present study. This is comparable to the report of Okeahialam et al, (1972) and Uzoegwu and Onwurah (2003) for children and adults respectively. However, in this present study, the difference in males and females infected with malaria parasite was not statistically significant and therefore infection was not dependent on sex.…”

Section: Discussionsupporting

confidence: 91%

Endemicity Of Malaria Among Primary School Children In Ebonyi State, Nigeria

Ani

2008

Anim. Res. Int.

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A study was undertaken to determine the prevalence of malaria among primary school children in Ebonyi State. The degree of malaria parasite, infection and species of the parasite isolated were used to determine the level of endemicity of the disease. Out of one thousand and two hundred (1,200) primary schoo children aged between 5-16 years sampled, the prevalence rate of 40.08 % was recorded. The species of the parasite associated with the disease was Plasmodium falciparum. It was observed that the rate of malaria parasitaemia was higher in younger (aged 5-10 years) than those of older (aged 11-16 years) children. A X l i. f 2test conducted on the infection rate according to ages of the pupils showed significant difference between the age groups indicating that infection was age dependent (P < O.O5). Greater number of males (243) than females (238) were infected but the infection rate according to sex was found not to be significant and therefore not sex dependent (P > 0.05). Among the Local Government Areas, Ivo had the highest prevalence rate. This was followed by Ishielu and Abakaliki local government areas of Ebonyi State. The results showed that malaria is endemic in the state and a major health problem for school children. The possible effect on academic performance was d scussed

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Section: Discussionsupporting

confidence: 91%

Endemicity Of Malaria Among Primary School Children In Ebonyi State, Nigeria

Ani

2008

Anim. Res. Int.

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“…Alternately, 20 µl of uncoagulated whole blood was mixed with 60 µl of distilled water and the resulting haemoglobin lysate spotted directly for haemoglobin genotype determination. Haemoglobin genotypes were determined by cellulose acetate membrane electrophoresis (CAME) of Evans (1971) as modified by Uzoegwu and Onwurah (2003).…”

Section: Preparation Of Haemoglobin Lysate and Haemoglobinmentioning

confidence: 99%

“…Sickle gene is widely distributed in malarial belts of Africa, but its frequency varies widely in different West African populations (Allison, 2002). The prevalence of sickle cell disease (SCD) in Africa ranges from 1 -10 % while the sickle heterozygous state range between 15 -40.5 % in malaria endemic areas (American Academy of Family Physicians, 1994, Uzoegwu and Onwurah, 2003). The high frequency of HbS and G6PD deficiency genes in some malaria endemic areas parallels the historical incidence of malaria (Allison, 1954;Allison and Clyde, 1961).…”

Section: Introductionmentioning

confidence: 99%

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Uzoegwu¹,

Awah²

2008

Anim. Res. Int.

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Hereditary disorders of erythrocytes are common in many areas of the world, including Cameroon Limited knowledge on the consequences of high incidences of sickle haemoglobin (HbS) and glucose-6-phosphate dehydrogenase (G6PD) deficiency genes in the Cameroons might have been responsible for the haemoglobin genotype mismatched marriages among the sickle heterozygotes and drug-induced anaemia among the G6PD deficient individuals ignorantly treated w th oxidant drugs having high redox potential. The situation therefore, informed the random screening of the populace of the North West and South West populat ons of Cameroon for these genes w th a view not only to reveal their current incidences and level of interaction but also to educate the people on the consequences of these genetic defects. Our results revealed the total incidences of 32.20 % sickle and 11 61 % G6PD deficiency genes. The percentage frequency of the sickle cell gene was higher in the South western (18 80 %) than in the North West (14 51 %) populations. The percentage incidence o G6PD deficiency was 9 21 % and 1 20 % for males and females respect vely in the North West and 10.85 % and 1.46 % for males and females respectively in the South West. The interaction was not s gnificant (P > 0.01) between G6PD deficiency and HbS for the North West and South West populat ons. These genetic defects must have reached polymorphic levels due to natural selection through survival advantage against death from malaria and consanguineous marriages. .

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“…Table 3 shows the level of some liver enzymes in P. falciparum patients and control subjects based on age. AST level was found to be significantly higher among age group (51 and above) in the P. falciparum patients and significantly lower among age group (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) in the control subjects when compared to other age groups. ALT level was significantly higher (P < 0.001) among age group (51 and above) in the P. falciparum patients and significantly lower among age group (41-50) in the control subjects when compared to other age groups.…”

Section: Discussionmentioning

confidence: 81%

“…ALT level was significantly higher (P < 0.001) among age group (51 and above) in the P. falciparum patients and significantly lower among age group (41-50) in the control subjects when compared to other age groups. ALP level was significantly higher among age group (41-50) in the P. falciparum patients and significantly lower among age group (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) in the control subjects when compared to other age groups. Table 4 shows the mean level of liver enzymes activities at different levels of parasite density or parasitaemia in P. falciparum malaria patients and control subjects.…”

Section: Discussionmentioning

confidence: 84%

Changes in Liver Function Enzymes in Plasmodium falciparum Infected Malaria Patients in Ajeromi General Hospital, Lagos, Nigeria

Ozojiofor

Bankole

Adedeji

et al. 2020

AJRB

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Objective: This study is to determine the changes in liver function enzymes in P. falciparum-infected patients in Ajeromi ifelodun area of Lagos, Nigeria by examining changes in some liver enzymes: Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline phosphatase (ALP) obtained from newly diagnosed cases of malarial infection yet to be treated. Study Design: Seventy (70) human subjects comprising of 50 P. falciparum malarial infected and 20 non-infected (control) subjects between 10-60 years were selected for this study. Malaria positive subjects were divided into three groups based on the number of parasite per μl. Those that had parasitaemia below 10,000 parasites per μl were considered a mild infection, those that had parasitaemia above 10,000 parasites per μl were considered severe infections and those with parasitaemia below 1,000 parasites per μl were considered a low infection. RDT test and microscopy was carried out to ascertain the presence of P.falciparum. They were grouped based on age group, sex and level of parasitaemia. Materials and Methods: Blood samples were collected for the determination of P. falciparum, level of parasitaemia and liver function enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP). P. falciparum was determined by Rapid Diagnostic Test (RDT) and microscopy. Results: There was a significant increase (P < 0.001) in the mean level of serum Aspartate Transaminase (AST), Alanine Transaminase (ALT) and a significant decrease in the mean level of alkaline phosphatase (ALP) in the P. falciparum-infected patients compared to the control subjects. AST level was found to be significantly higher (P<0.001) among age group (51- above) in the P. falciparum patients and significantly lower among age group (10-20) in the control subjects when compared to other age groups. ALT level was significantly higher (P < 0.001) among age group (51- above) in the P. falciparum patients and significantly lower among age group (41-50) in the control subjects when compared to other age groups. ALP level was significantly higher (P < 0.001) among age group (41-50) in the P. falciparum patients and significantly lower among age group (10-20) in the control subjects when compared to other age groups. AST and ALT were found to be significantly higher (P < 0.001) in the high parasitaemia group when compared to the low and moderate parasitaemia group and they were also significantly higher in the moderate parasitaemia group than in the low parasitaemia group.ALP was significantly higher (P < 0.001) in the moderate parasitaemia group when compared to the low and high parasitaemia group and they were only marginally lower in the high than in the low parasitaemia group. Conclusion: There was an elevated level of liver function enzymes in the P. falciparum patients than in the control subjects. This study shows that high parasitaemic patients are at greater risk of hepatic damage than the low parasitaemic group, hence early diagnosis and treatment of malaria are highly encouraged.

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Correlation of Lipid Peroxidation Index With Sickle Haemoglobin Concentrations In Malaria-Positive and-Negative Statuses of AA, AS and SS Individuals from the University of Nigeria, Nsukka Community

Cited by 7 publications

References 0 publications

Endemicity Of Malaria Among Primary School Children In Ebonyi State, Nigeria

Endemicity Of Malaria Among Primary School Children In Ebonyi State, Nigeria

Prevalence Of Sickle Haemoglobin And Glucose–6–Phosphate Dehydrogenase Deficiency Genes In The Populations Of North West And South West Provinces, Cameroon

Changes in Liver Function Enzymes in Plasmodium falciparum Infected Malaria Patients in Ajeromi General Hospital, Lagos, Nigeria

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