Correlation of low vitamin D status with atopic dermatitis severity in children

Abstract

Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D has some roles in immunologic mechanisms. Vitamin D may influence the severity of AD. Previous studies of vitamin D correlation in children with atopic dermatitis have revealed conflicting results. This study determines the correlation between low vitamin D status with the severity of atopic dermatitis in children. Methods: This is a cross-sectional analytical study with a cross-sectional approach that involved DA subjects aged ≤17 years with low vitamin D status. The recording of basics data and examination of subjects included assessing the scoring atopic dermatitis (SCORAD) score and measuring 25-hydroxyvitamin D (25(OH)D) level for all subjects. Statistical analyses were performed using Pearson's correlation coefficients, with P<0.05 was considered statistically significant. Result: A total of 30 subjects with AD with the most extensive distribution was in the age group of 11–17 years (53.33%), sex proportions were equal both male (50%) and female (50%), all subjects have an atopic family history (100%). The mean vitamin D level was 18,02 ± 4,56 ng/ ml (deficiency), and the mean SCORAD score was 20,03 ± 5,80 (mild). There was a significantly strong negative correlation between low serum vitamin D level and severity of AD in children (r = -0.666, p = 0.001). Conclusion: Lower vitamin D status is inversely associated with the severity of AD in children.Â

Evaluation of the Impact of Serum Vitamin D Levels on the Scoring Atopic Dermatitis Index in Pediatric Atopic Dermatitis

“…Furthermore, we have identified a strong negative correlation between serum vitamin D levels and the severity of AD. These results are consistent with prior research, which consistently reported an inverse relationship between serum vitamin D levels and the severity of AD [5,16,34,37]. In a recent study conducted by Bulut et al, a negative correlation was observed between serum 25(OH)D3 levels and the severity of AD in 120 pediatric patients, which is in agreement with our findings [4].…”

“…Additionally, in line with the outcomes of our study, serum 25(OH)D3 levels were statistically lower in patients with severe AD compared to other groups [4]. Similar studies in the existing literature have reported a negative association between disease severity and serum 25(OH)D3 levels [2,5,16,34,37]. However, it is worth noting that some studies, in contrast to our findings, did not establish a correlation between disease severity and serum 25(OH)D3 levels [17,18,38].…”

Vitamin D and Wound Recovery: Illuminating the Path to Enhanced Healing in Diabetic Patients

“…Vitamin D comprises a group of fat-soluble secosteroids, with the term commonly referring to two main forms: vitamin D2 (ergocalciferol), derived from plant sterol ergosterol, and vitamin D3 (cholecalciferol), derived from animal 7-dehydrocholesterol. 11 Dietary sources provide a small amount of vitamin D, encompassing both vitamin D2 and vitamin D3. The primary source of circulating vitamin D, predominantly vitamin D3, is synthesized in the skin from 7-dehydrocholesterol (7-DHC) upon exposure to sunlight.…”

Bacterial colonization in atopic dermatitis

“…3,4 AD is a complex skin disease caused by the interaction of various factors such as genetic factors, skin barrier factors, predisposing factors, environmental factors and precipitating factors. 5, 6 Precipitating factors vary widely, ranging from irritants, contact and inhaled allergens, and infection with microorganisms. The pathogenesis of AD begins with the entry of allergens captured by APC cells which will then be processed and presented to T cells.…”