Introduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D has some roles in immunologic mechanisms. Vitamin D may influence the severity of AD. Previous studies of vitamin D correlation in children with atopic dermatitis have revealed conflicting results. This study determines the correlation between low vitamin D status with the severity of atopic dermatitis in children. Methods: This is a cross-sectional analytical study with a cross-sectional approach that involved DA subjects aged ≤17 years with low vitamin D status. The recording of basics data and examination of subjects included assessing the scoring atopic dermatitis (SCORAD) score and measuring 25-hydroxyvitamin D (25(OH)D) level for all subjects. Statistical analyses were performed using Pearson's correlation coefficients, with P<0.05 was considered statistically significant. Result: A total of 30 subjects with AD with the most extensive distribution was in the age group of 11–17 years (53.33%), sex proportions were equal both male (50%) and female (50%), all subjects have an atopic family history (100%). The mean vitamin D level was 18,02 ± 4,56 ng/ ml (deficiency), and the mean SCORAD score was 20,03 ± 5,80 (mild). There was a significantly strong negative correlation between low serum vitamin D level and severity of AD in children (r = -0.666, p = 0.001). Conclusion: Lower vitamin D status is inversely associated with the severity of AD in children.Â

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Corticosteroids are commonly used in the medical specialty of dermatology because of their antiinflammatory and immunosuppressive effects. Skin hypersensitivity reactions have also been reported with systemically administered corticosteroids. Most of these skin reactions are widespread at presentation, including generalized dermatitis and urticarial reactions. We presented a case of a 25-year-old woman with shortness of breath accompanied by complaints of red bumps on the neck, trunk, back, stomach, hands and feet since 1 day ago. On examination of the dermatological status, it was found in the anterior thoracic region, posterior thoracic region, abdominal region, superior extremity region, and inferior extremity region. There is urticarial fluorescence, multiple, confluent and generalized. IgE examination showed an increase of 6 times the normal level. Therapy includes oral administration of methylprednisolone, antihistamines, and topical corticosteroids result in good outcome.

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