Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Dalbaşı, Erkan; Gedik, Ercan; Tüzün, Abidin; Obay, Basra Deniz

doi:10.5798/dicletip.755706

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…The C‐reactive protein is an acute phase reactant. Its value increases in correlation with the severity of inflammation 30 . Studies have found that CRP has a high sensitivity in the diagnosis of AA 31 .…”

Section: Discussionmentioning

confidence: 99%

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Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Dalbaşı

Akgül²

2021

Int J Clin Pract

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Background: Acute appendicitis (AA) is the most common cause of surgery performed for the acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. The use of broad-spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim: Evaluate whether white blood cell (WBC), platelet count, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW) and Creactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal computed tomography (CT) could be a marker for choosing medical or surgical treatment. Materials and Methods: 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. The presence of at least one How to cite this article: Dalbaşı E, Akgül ÖL. Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?.

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Section: Discussionmentioning

confidence: 99%

“…Its value increases in correlation with the severity of inflammation. 30 Studies have found that CRP has a high sensitivity in the diagnosis of AA. 31 These findings are compatible with our study.…”

Section: Ta B L E 2 Laboratory Parameters Of Groups F I G U R Ementioning

confidence: 99%

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Dalbaşı

Akgül²

2021

Int J Clin Pract

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“…The C-reactive protein is an acute phase reactant. Its value increases in correlation with the severity of inflammation (31). Studies have found that CRP has a high sensitivity in the diagnosis of AA (32).…”

Section: Discussionmentioning

confidence: 99%

Are Average Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Platelet Distribution Width (PDW) Guiding Markers for Acute Appendicitis Treatment Options?

Dalbaşı¹,

Akgül

2021

Preprint

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Background: Acute appendicitis (AA) is the most common cause of surgery performed for acute abdomen. The standard treatment for AA patients has been appendectomy for more than a century. use of broad-spectrum antibiotics, the medical treatment option has come to the fore in the treatment of uncomplicated AA. Aim: Evaluate whether WBC, platelet count, MPV, PDW, RDW, and C-reactive protein (CRP) values of patients diagnosed with uncomplicated AA clinically, with laboratory tests and radiologically with abdominal CT could be a marker for choosing medical or surgical treatment. Material and Method: 519 patients aged between 20 and 65 years who were diagnosed with uncomplicated AA by abdominal CT in our centre between January 2016 and January 2019 were retrospectively analysed. . The presence of at least one of the criteria of 7 mm or more appendix diameter and oedema or fluid accumulation around the appendix was accepted as uncomplicated AA. After the diagnosis of AA, 223 patients were treated medically, while 296 patients underwent laparoscopic appendectomy. The first group included patients who were treated medically and the second group included patients who underwent laparoscopic appendectomy. Results: Group 2 patients had higher mean platelet count (p <.005) and RDW (p = .003) values compared to Group 1 patients, while mean PDW (p <.001) values were lower compared to those of Group 1 patients. The differences between the mean WBC, CRP and MPV values of the groups were not statistically significant (p>0.05). Conclusions: The standard treatment for acute appendicitis is surgery. Recently, studies supporting antibiotic therapy have been conducted in patients diagnosed with AA. As a result, we think that PDW, RDW, and platelet values in patients diagnosed with uncomplicated AA may be a guide in choosing patients to be treated with surgery or antibiotics. Key Words: acute appendicitis, laparoscopic appendectomy, antibiotic therapy.

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“…It has to be noted that lipids are one of the main targets of oxidation damage to reactive oxygen species, because there occurs dysbalance between formation and neutralizations of free-radical compounds (Nesterov et al, 2018). Intensification of free-radical oxidation of lipids leads to progression of the pathological processes, accompanied by lesions of the liver, first of all, as a result of damage to hepatocytes, their edema, ruination of mitochondria and lysosomes, influx of highly toxic products of cellular metabolism into blood and lysosome enzymes (Savchenko et al, 2017;Dalbaşı et al, 2020;Verveha, 2021).…”

Section: Introductionmentioning

confidence: 99%

Oxidative modification of proteins and antioxidant status in blood of the rats with experimental acute generalized peritonitis against the background of streptozotocin-induced diabetes

Verveha,

Gutyj,

Lishchuk

et al. 2023

Regul. Mech. Biosyst.

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Modern aspects of the pathogenesis of acute inflammation of the peritoneum that is concurrent with diabetes involves analysis of metabolic mechanisms, in particular peroxidaton of proteins – antioxidant defense. Therefore, the objective of our study was to examine the interrelation between the processes of free-radical oxidation of proteins and antioxidant system in the dynamics of development of acute generalized peritonitis against the background of streptozotocin-induced diabetes. The study was performed on 56 non-linear white mature male rats. Diabetes mellitus was modeled by a single intraperitoneal injection of streptozotocin (60 mg/kg). On the 14th day of the development of streptozotocin-induced diabetes, we injected 10% filtrated faeces suspension (0.5 mL) into the abdominal cavity, thus initiating acute generalized peritonitis. Oxidative modification of proteins in blood serum was studied using the I. F. Meshchyshen’s method and the condition of antioxidant protection was monitored according to the activities of superoxide dismutase, catalase, content of reduced glutathione, and the level of ceruloplasmin. The study of the parameters of free-radical oxidation of proteins and study of the condition of antioxidant system in blood of the rats with experimental acute generalized peritonitis against the background of streptozotocin-induced diabetes demonstrated that oxidative protein modification grew, while the parameters of the activity of antioxidant system were being inhibited, depending on the stage of acute inflammation of the peritoneum. We determined inverse correlation relationships between the products of free-radical oxidation of proteins and parameters of antioxidant system on the third and on the seventh days of modelling of combined pathology. Manifestation of acute generalized peritonitis concurring with streptozotocin-induced diabetes was accompanied by a gradual accumulation of the products of free-radical oxidation of proteins and exhaustion of the antioxidant defense during all stages of the development of acute inflammation of the peritoneum, peaking on the seventh day after administration of faecal suspension (terminal stage of peritonitis). The observed inverse correlations between the levels of oxidative modification of proteins and the activity of superoxide dismutase, catalase, reduced glutathione, and ceruloplasmin on the third and on the seventh days of modelling of combined pathology indicate a predictive role of the processes of free-radical oxidation of proteins in exhaustion of antioxidant-defense resources.

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Correlation of Malondialdehyde and Antioxidant Enzyme Levels with Peritonitis Severity in Patients with Generalized Peritonitis

Cited by 5 publications

References 17 publications

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Are average platelet volume, red cell distribution width and platelet distribution width guiding markers for acute appendicitis treatment options?

Are Average Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Platelet Distribution Width (PDW) Guiding Markers for Acute Appendicitis Treatment Options?

Oxidative modification of proteins and antioxidant status in blood of the rats with experimental acute generalized peritonitis against the background of streptozotocin-induced diabetes

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