Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma

Chang, Chongwang; Shi, Hangyu; Wang, Chao; Wang, Jing; Geng, Ning; Xue, Jian; Wang, Xuelian

doi:10.1016/j.neulet.2012.10.021

Cited by 61 publications

(41 citation statements)

References 26 publications

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“…Deregulated miR-375 expression has been indicated in various cancer types including oral carcinoma [17], breast cancer [18], esophageal adenocarcinoma, lung cancer [19], glioma [20], gastric cancer [21], and hepatocellular carcinoma [22]. More recently, elevated miR-375 expression was found in gastric cancer, and miR-375 can desensitize cells to ionizing radiation and etoposide by targeting p53 [23].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA

Shi

Chu

et al. 2015

Tumor Biol.

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Osteosarcoma has become one of the most common primary malignant bone tumors in childhood and adult. Numerous studies have demonstrated that aberrant microRNA (miRNA) expression is involved in human disease including cancer. To date, the potential miRNAs regulating osteosarcoma growth and progression are not fully identified yet. Herein, we showed that miR-375 was frequently downregulated in osteosarcoma tissue and cell lines compared to normal human colon tissues. Overexpression of miR-375 resulted in decreased expression of PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) at both mRNA and protein levels. We found that miR-375 overexpression markedly suppressed cell proliferation in vitro. And inhibition of miR-375 promotes osteosarcoma growth. Mechanistic studies showed that PIK3CA was a potential target of miR-375 and it mediated reduction of PIK3CA resulted in suppression of PI3K/Akt pathway. Taken together, our results demonstrate that miR-375 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA in osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA

Shi

Chu

et al. 2015

Tumor Biol.

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“…Recently, genome-wide miRNA expression profiling studies revealed that miR-375 is widely present in various tissues and organs, and its expression is significantly aberrant in malignant tumors, such as HNSCC, NSCLC, melanoma, glioma, hepatocellular, esophageal, gastric, breast, and prostate cancer [10–16, 19, 27]. It is indubitable that miR-375 is an important cancer-related miRNA.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis

Shao

Geng

et al. 2014

Disease Markers

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Objective. Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall survival (OS). Methods. Studies were identified by searching PubMed, Embace, and Cochrane Library (last search update was in May 2014) and were assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for total and stratified analyses were calculated to investigate the association between miR-375 expression and cancer patients OS. Results. Our analysis results indicated that downregulation of miR-375 predicted poor OS (HR = 1.91, 95% CI 1.48–2.45, P < 0.001). Subgroup analyses showed that lower expression of miR-375 was significantly related with poor OS in patients with esophageal carcinoma (HR = 2.24, 95% CI 1.69–2.96, P < 0.001) and non-small-cell lung cancer (NSCLC) (HR = 1.71, 95% CI 1.31–2.24, P < 0.001). Conclusions. The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker.

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“…MiRNA-138 was found to be reduced in glioblastoma multiforme (GBM) specimens and was demonstrated to be a tumor suppressor in GBM tumorigenicity, suggesting a potential application in GBM therapy (Qiu et al 2013). It was found that miR-375 expression was significantly decreased in glioma tissues and the low miR-375 expression was significantly associated with advanced pathological grade (Chang et al 2012). It was revealed that intestinal ischemia induced a time-dependent increase of miR-874 expression, implying that miRNA-874 was involved in the intestinal ischemia (Zhi et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Identification of Conserved and Novel microRNAs in Cerebral Ischemia-Reperfusion Injury of Rat Using Deep Sequencing

et al. 2014

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MicroRNAs are a class of noncoding small RNAs that regulate gene expression by inhibiting target genes at post-transcriptional levels. MicroRNAs have been highlighted in many organs and tissues, including the brain. To identify special microRNAs involved in ischemia-reperfusion injury, we performed a comprehensive small RNA profiling in rat model and the control using Illumina high-throughput sequencing. A total of 9,444,562 and 10,290,391 clean reads were sequenced from two small RNA libraries constructed, respectively. Three hundred fifty-eight known microRNAs were identified, in which 78 microRNAs exhibited significantly differential expression between model and control. In addition, 62 and 68 novel miRNAs were found in model and control, respectively. Comparative analysis showed that 24 novel microRNAs were differentially expressed with greater than six-fold change. The GO annotation suggested that predicted targets of microRNAs were enriched into the category of metabolic process, cell part, cell-extracellular communications, and so on. KEGG pathway analysis suggested that these genes were involved in many important pathways, mainly including signaling transduction, MAPK signaling pathway, NF-κB signaling pathway, and neurotrophin signaling pathway. Our findings provided a deeper understanding to the regulatory mechanism of microRNAs underlying cerebral ischemia, therefore benefitting the improvement of the protection and treatment strategies of this disease.

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Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma

Cited by 61 publications

References 26 publications

MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA

MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA

Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis

Identification of Conserved and Novel microRNAs in Cerebral Ischemia-Reperfusion Injury of Rat Using Deep Sequencing

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