Correlation of obesity and the novel adipocytokines, leptin and adiponectin with insulin resistance in type 2 diabetes

Das, Piyali; Bandyopadhyay, Subir Kumar; Biswas, Soumali; Bhattacharya, Gourav; Manna, Madhumita

doi:10.3329/bjpp.v30i1.20791

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…21 Meanwhile from Buyukbese study, we had leptin levels to be 40.22±17.77 ng/ml in diabetes compared to 50.12±15.55 ng/ml in the control though the later cases were all obese which corresponds to the study of that states the association of a higher leptin level with obesity. [22][23][24] This is in contrast to this study as the leptin levels in the diabetes were not significantly different from the control which corroborates the report from Haffner which stated a non significant differences in the concentratrion of leptin in diabetes and non diabetes. 25 This study agrees with the report of Abu-Ssayed where low levels of leptin may be attributed to lean diabetics which might be as a result of the fat distribution within the subjects since they are all on normal weight.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of serum leptin levels in diabetic and hypertensive subjects resident in Port Harcourt

Waribo

2023

Int J Res Med Sci

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Background: Diabetes and hypertension which are metabolic conditions are becoming more common and prevalent in the world. Prolonged rise of blood sugar levels, is a hallmark of diabetes, a metabolic condition caused by problems with insulin production, insulin resistance or both while hypertension is the persistent high blood pressure in the arteries. Leptin is a hormone that inhibits appetite, reduces fat storage in adipocytes and aids in the regulation of energy balance hence implicated in diabetes and insulin resistance. Thus, can metabolic state affects its level in the serum. Methods: The study population is two hundred and forty (240) subjects that are residents of Port Harcourt aged between 30-70 years. Sixty subjects were used as the control, sixty subjects were diabetes, the other sixty subjects were hypertensive while the remaining sixty were subjects with both hypertension and diabetic mellitus. An enzyme-linked immunosorbent assay (ELISA) method was used to quantitatively measure leptin levels in the serum sample, glycated haemoglobin were determined quantitatively using sandwich immunodetection and blood pressure was measured using mercury sphygmomanometer. Results: The data generated were statistically analysed using Graph Pad Prism version 9.0.2. The results showed no significant difference in leptin levels in diabetics, hypertensive and subjects having both diabetes and hypertension when compared with the control subjects having none of these metabolic disorders (p =0.4166). Conclusions: Our results shows that leptin levels in the population were relatively within the reference ranges both for males (0.5-12ng/ml) and females (0.5-15ng/ml). It clearly shows that metabolic conditions (diabetes or hypertension) does not affect leptin levels in serum.

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Section: Discussionsupporting

confidence: 83%

Evaluation of serum leptin levels in diabetic and hypertensive subjects resident in Port Harcourt

Waribo

2023

Int J Res Med Sci

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“…Study concluded that, obesity mainly of central or abdominal type might be responsible for the insulin resistance in type 2 diabetes mellitus whereas leptin, a potential marker for obesity was probably not involved. This perhaps points towards the multifactorial causation of insulin resistance in type 2 diabetes mellitus [8].…”

Section: Discussionmentioning

confidence: 95%

“…which are released by the adipose tissue, thus it is suggested that such altered level of adipokines are involved in the pathogenesis of obesity associated diabetes. Leptin level increases in obesity and its correlation with body mass index (BMI) and glucose levels has already been reported in different populations [8][9][10][11]. As we already had reported blood levels of adiponectin in a small population from Faisalabad, Pakistan [12] there is no such data for leptin levels for this population.…”

Section: Introductionmentioning

confidence: 92%

Leptin Correlation with Obesity, Diabetes and Gender in a Population from Faisalabad, Pakistan

Najam¹,

Awan²,

Islam³

et al. 2016

Arch Med

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Background: Leptin is an important adipokine hormone released from adipose tissue which is associated with obesity and diabetes in different populations.Objective: To investigate the serum leptin concentrations for its correlation with diabetes, obesity and gender in a small population from Faisalabad, Pakistan.Methods: From our sample collection of more than 500 subjects for metabolic disorders research, we have carefully selected 80 subjects for the present case-control comparison study. These subjects were grouped on the basis of diabetes, obesity and gender status. Equal number of subjects was taken for each comparison group to minimize the effects of confounding factors. For diabetes, these eighty subjects were divided into two groups (n=40 non-diabetic and n=40 type 2 diabetics). While considering obesity, these eighty subject were divided on the basis of their Body Mass Index (n=40 non-obese and n=40 obese). For gender based analysis, the groups based on diabetes and obesity were made (n=20 in each sub-group) and further analyzed while keeping n=10 males and n=10 females in each sub-group. Serum leptin and biochemical analytes were measured for all subjects and data were analyzed by SPSS 18.0 software.Results: Leptin levels were found significantly low in nonobese as compared to obese subjects (Mean ± SD: 5.2 ± 2.0 vs. 7.1 ± 2.1 ng/ml, p<0.001). No significant difference was found for non-diabetics and diabetics (6.4 ± 2.4 vs. 5.9 ± 2.2 ng/ml, p=0.35). Gender dimorphism showed significant differences for leptin (p<0.0001). Spearman's analysis showed strong correlation between leptin and obesity (r=0.43, p=0.0001), gender (r=0.24, p=0.02) irrespective of obesity or diabetes. Conclusion:The leptin levels were high in obese and female subjects.

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“…[34] Contrary to previous studies, Martin et al found a direct positive association between obesity and serum leptin, hyperinsulinemia, and IR but not strong relation to other components of metabolic syndrome [35] on other hand, previously concluded that serum leptin, through obesity marker, does not significantly end towards the multifactor causation of interactions between adipocytokines are proposed to be involved in the defect in IR, and any single molecule alone including leptin may have not significant associations with the level of IR. [36] Increased leptin levels in obese, diabetic patients may indicate leptin resistance; and since leptin is a strong regulator of insulin sensitivity/glucose homeostasis, it is possible that when leptin resistance develops it may worsen IR.…”

Section: Discussionmentioning

confidence: 99%

Association of serum leptin and insulin levels among type 2 diabetes mellitus patients: A case–control study

Zhao

2022

Medicine

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Secretion of insulin is compromised in type 2 diabetes (T2DM) individuals and inadequate to accommodate for insulin resistance (IR) in peripheral tissue. Hyperleptinemia reflects leptin resistance, which is a key factor in the production of IR in T2DM patients, making leptin a potential biomarker for evaluating IR levels. The objective of the study was to assess the association of serum leptin and insulin levels among T2DM patients. This case-control research was carried out on T2DM patients. A total of 73 patients diagnosed with T2DM (the case group) and 40 healthy participants (control; group 3) were enrolled according to the American Diabetes Association (ADA) criteria. In the case group, T2DM patients were enrolled with metabolic syndrome (group 1, n = 38) or without metabolic syndrome (group 2, n = 35) according to the WHO criteria. Metabolic profiles of T2DM patients with or without metabolic syndrome were evaluated, and compare these two groups with healthy controls. The subjects of all groups were age- and gender-matched. Body mass index (BMI, P < .01), fasting ( P = .0133) and postprandial ( P < .01) blood sugar levels, % glycated hemoglobin (HbA1c, P < .01), and lipid profile ( P < .01) were found significantly different and higher in group 1 as compared to groups 2 and 3. Serum leptin and insulin levels were found higher and significant in patients with metabolic syndrome ( P < .01 for both). The values of serum leptin levels were 10.01 ± 2.7 ng/mL, 6.9 ± 2.4 ng/mL, and 4.11 ± 1.8 ng/mL, and those of serum insulin 120 ± 40.7 µIU/mL, 20.43 ± 5.2 µIU/mL, and 11.4 ± 2.5 µIU/mL in groups 1, 2, and 3, respectively. There was a positive linear correlation between BMI, blood sugar, HbA1c, serum cholesterol (TC), and triglycerides (TG) with serum insulin and leptin levels in the case group. An extremely significant correlation ( R = 0.74, P < .001) was found in BMI and serum leptin level in the case group. Serum leptin and insulin levels have a positive association, with serum leptin being a significant predictor of IR syndrome (Evidence Level: 5; Technical Efficacy: Stage 3).

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Correlation of obesity and the novel adipocytokines, leptin and adiponectin with insulin resistance in type 2 diabetes

Cited by 3 publications

References 14 publications

Evaluation of serum leptin levels in diabetic and hypertensive subjects resident in Port Harcourt

Evaluation of serum leptin levels in diabetic and hypertensive subjects resident in Port Harcourt

Leptin Correlation with Obesity, Diabetes and Gender in a Population from Faisalabad, Pakistan

Association of serum leptin and insulin levels among type 2 diabetes mellitus patients: A case–control study

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