Correlation of Olfactory Function With Changes in the Volume of the Human Olfactory Bulb

Haehner, Antje; Rodewald, Antje; Gerber, Johannes; Hummel, Thomas

doi:10.1001/archotol.134.6.621

Cited by 110 publications

(90 citation statements)

References 21 publications

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“…2,19 The correlation of olfactory function with volume of the human OB has been established. 24,37 In this study, a positive correlation between olfactory deficit and OB volume was found both in patients with PD and controls. It may be that olfactory dysfunction in PD is related to loss of olfactory neurons or disrupted input to the OB.…”

Section: Discussionsupporting

confidence: 62%

“…The bilateral volume of the OB and the depth of the OS were measured in all study subjects. Because there may be differences between left-and rightsided OB volumes and OS depth, [22][23][24] we used the maximum volume of the OB and depth of the OS in each individual for the analysis. The OB volume was expressed in cubic millimeters by calculating the inplane area and the thickness of the OB.…”

Section: Imaging Data Analysesmentioning

confidence: 99%

See 1 more Smart Citation

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

Wang¹,

You²,

Liu³

et al. 2011

AJNR Am J Neuroradiol

129

109

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Section: Discussionsupporting

confidence: 62%

Section: Imaging Data Analysesmentioning

confidence: 99%

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

Wang¹,

You²,

Liu³

et al. 2011

AJNR Am J Neuroradiol

129

109

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show abstract

“…Given that a larger olfactory bulb volume is indicative of better olfactory function (Haehner et al, 2008), it is possible that the volume of the bulb directly relates with the functional needs and therefore the behavioral ecology of the above species.…”

Section: Discussionmentioning

confidence: 99%

Comparative Morphometry of the Olfactory Bulb, Tract and Stria in the Human, Dog and Goat

Kavoi

Hassanali

2011

Int. J. Morphol.

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SUMMARY:Morphometric parameters of olfactory brain components show species-dependent variations. However, the association of these parameters with olfactory function vis-à-vis ecological and evolutionary behaviors is poorly understood. In this study, a morphometric analysis of the olfactory bulb, tract and stria was carried out in three ecologically diverse animals comprising humans (primate), dogs (carnivore) and goats (herbivore) to elucidate differences in morphometry in relation to olfactory function. Using formalin-fixed brains, volumes and linear measurements of the olfactory structures were determined and correlated with those of cerebrum and the whole brain. The volume of the olfactory bulb was greatest in dogs, followed by goats and humans and constituted 0.31%, 0.18% and 0.01%, respectively, of the brain volume. Similarly, the ratio of volume of the bulb, tract and stria to that of brain was 1.95% in the dog, 0.77% in the goat and 0.03% in the human. The width of the bulb was greatest (p< 0.05) in dogs (10.80± 1.64mm) compared to goats (8.25± 0.96mm) and humans (5.50± 0.71mm), and accounted for a hemisphere breadth of 42.91%, 29.73% and 8.94% respectively. Interestingly though, the total length of the olfactory bulb, tract and striae increased in the order of goat (34.5±1.30mm), human (36.25±1.70mm) and dog (48.20±1.92mm), and constituted 21.47%, 51.87% and 72.30%, respectively, of the hemisphere length. These results suggest that the morphometric adaptations of the olfactory components to olfactory function decline from the dog, to goat, to human, and this may be indicative of the varied olfactory functional needs in regard to the ecological diversity of these species.

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“…If the connection between depression and olfaction is a temporal phenomenon that disappears after remission of depression, OB volume could also be hypothesized to recover after successful psychotherapy. Volumetric changes of the OB are described in several studies in humans both in connection to peripheral Haehner et al 2008)) or central disorders (Hummel et al 2013b;Turetsky et al 2000Turetsky et al , 2003Yousem et al 1998Yousem et al , 1999. However, studies provide contradictory information on the potential for neurogenesis either within the OB or through progenitor cells derived from the sub-ventricular zone (SVZ) through the rostral migratory stream (RMS) (see (Bergmann et al 2012;Huart et al 2013;Lotsch et al 2013) for ongoing debate).…”

Section: Introductionmentioning

confidence: 99%

Olfactory bulb volume predicts therapeutic outcome in major depression disorder

Negoiaș

Hummel

Symmank

et al. 2015

Brain Imaging and Behavior

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The volume of the olfactory bulb (OB) is strongly reduced in patients with major depressive disorder (MDD) and this group exhibits markedly decreased olfactory function. It has been suggested that olfactory input is important for maintaining balance in limbic neurocircuits. The aim of our study was to investigate whether reduced OB volume is associated with response to therapy in MDD. Twenty-four inpatients (all women, age 21-49 years, mean 38 ± 10 years SD) with MDD and 36 healthy controls (all women, age 20-52 years, mean 36 ± 10 years SD) underwent structural MRI. OB volume was compared between responders (N = 13) and non-responders (N = 11) to psychotherapy. Retest of OB volume was performed about 6 months after the end of therapy in nine of the patients. Therapy responders exhibited no significant difference in OB volume compared to healthy controls. However, average OB volume of non-responders was 23 % smaller compared to responders (p = .0011). Furthermore, OB volume was correlated with the change of depression severity (r = .46, p = .024). Volume of the OB did not change in the course of therapy. OB volume may be a biological vulnerability factor for the occurrence and/or maintenance of depression, at least in women.

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Correlation of Olfactory Function With Changes in the Volume of the Human Olfactory Bulb

Abstract: To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function.

Cited by 110 publications

References 21 publications

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

Comparative Morphometry of the Olfactory Bulb, Tract and Stria in the Human, Dog and Goat

Olfactory bulb volume predicts therapeutic outcome in major depression disorder

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