Correlation of photodynamic activity and fluorescence signaling for free and pegylated mTHPC in mesothelioma xenografts

Abstract

Fluorescence signaling measurement has the potential to predict the photodynamic activity for both mTHPC formulations in mesothelioma xenografts.

Temoporfin (Foscan®, 5,10,15,20‐Tetra(m‐hydroxyphenyl)chlorin)—A Second‐generation Photosensitizer†,‡

“…Maximum fluorescence in this system was observed after 24 h with adequate tumor:skin (2.95) and tumor:muscle (6.61) ratios (470). Human malignant mesothelioma implanted in mice showed a similar PDT response for m THPC and m THPC‐MD 2000 but lower skin phototoxicity for the latter (486). Other studies focused on side‐effects (476) or the preparation of (487) and incorporation into nanocapsules (481,488).…”

Assessment of a sheep animal model to optimise photodynamic therapy in the oesophagus

“…This is probably because large intra-and inter-individual variations of the fluorescence intensity in the oesophagus seem to be frequent. It is interesting to note that this drawback may be solvent-dependent or formulation-dependent, as the fluorescence intensity of a modified formulation of mTHPC has the potential to predict photodynamic activity in some animal models [47].…”