Correlation of plasma brain-derived neurotrophic factor and metabolic profiles in drug-naïve patients with bipolar II disorder after a twelve-week pharmacological intervention

Lee, S. Y.; Chang, Yun-Hsuan; Chen, Po See; Huang, San Yuan; Tzeng, Nian Sheng; Wang, C. L.; Wang, L. J.; Lee, I‐Hui; Wang, Tzu Yun; Chen, Kao-Ching; Yang, Yue-Tzu; Hong, Jau–Shyong; Lu, Ru‐Band

doi:10.1111/acps.12324

Cited by 14 publications

(20 citation statements)

References 66 publications

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“…This finding was compatible with previous report [9,31], but not with the results of other studies [32,33]. Whether the BDNF levels alter significantly after treatment or stay unchanged has been a matter of much debate, with discordant data [11,13,14,34]. The reasons for these conflicting findings include mood stabilizer or antipsychotics metabolic polymorphisms and other confounding factors, including differences in patient characteristics (such as duration of mood stabilizer or antipsychotics intake, different clinical profiles, and sample size) and the tested materials (serum vs plasma).…”

Section: Bdnf Levels Before and After The 4-week Treatmentsupporting

confidence: 90%

Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

Wu¹,

Chiou²,

Huang³

2017

Neuropsychiatry

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Section: Bdnf Levels Before and After The 4-week Treatmentsupporting

confidence: 90%

Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

Wu¹,

Chiou²,

Huang³

2017

Neuropsychiatry

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“…Thirtyfive studies, comprising a total of 2238 bipolar disorder patients and 1560 healthy control subjects, were eligible for review and included in the meta-analysis with a minimum of one pair-wise comparison each. [11][12][13][19][20][21]26, Exclusion of full 63 text articles and reports were based on (a) data on BDNF levels were unavailable, [66][67][68] (b) patients not suffering from bipolar disorder, [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84] (c) the study not evaluating peripheral BDNF levels, (d) the study being a review or a comment, [107][108][109][110][111][112][113][114][115][116][117][118][119] (e) the study not comparing states or comparing bipolar patients with healthy control subjects [120][121][122] and/or (f) the study investigated treatment of experimental nature 123,124 and (g) the study presenting duplicate data presented in an included article. …”

Section: Study Selectionmentioning

confidence: 99%

“…11,13,19,20,26,[38][39][40][41][42] Ten studies provided data for comparisons between affective states in bipolar disorder patients, 12,19,20,26,38,41,42,46,48,65 of which two studies 12,26 included within-subject comparisons between a manic and euthymic state and one study 26 included withinsubjects comparisons between a depressed and euthymic state and a depressed and manic state (Supplementary Table 2-4S). Seven studies investigated changes in BDNF levels before and after treatment of an acute affective episode, 12,21,43,46,47,57,64 with follow-up periods ranging from 4 to 52 weeks. In five studies the intervention included a combination or different medication types (lithium, antipsychotics and anticonvulsants), 12,46,47,57,64 one study investigated BDNF changes before and after lithium treatment 43 and one study investigated changes before and after valproate treatment 21 (Supplementary Table 5-6S).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven studies investigated changes in BDNF levels before and after treatment of an acute affective episode, 12,21,43,46,47,57,64 with follow-up periods ranging from 4 to 52 weeks. In five studies the intervention included a combination or different medication types (lithium, antipsychotics and anticonvulsants), 12,46,47,57,64 one study investigated BDNF changes before and after lithium treatment 43 and one study investigated changes before and after valproate treatment 21 (Supplementary Table 5-6S). Of the included studies, 33 were published as peer-reviewed articles, while two were available as conference abstracts only.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…19,20 None of previous reviews have compared BDNF levels between affective states directly, relying on indirect evidence and did not evaluate the effect of medication in group-wise comparisons. More importantly, the incomplete matching between groups and the inherent risk of confounding related to several variables known to affect BDNF levels, such as body mass index (BMI), 21 exercise, 22 smoking and alcohol use, 23 was not addressed in a critical evaluation of the evidence and conclusions. It is therefore timely to critically review the current evidence, including evaluation of study quality and of potential confounding moderators, incorporating the large and recent body of research.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis

2015

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Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded conflicting results with substantial variation in outcomes, highlighting the need to critically assess the state of current evidence. The aims of the study were to investigate differences in peripheral blood BDNF concentrations between bipolar disorder patients and healthy control subjects and between affective states in bipolar disorder patients, including assessment of the effect of treatment of acute episodes on BDNF levels. A systematic review of English language studies without considering publication status was conducted in PubMed (January 1950-November 2014), Embase (1974-November 2014) and PsycINFO (1806-November 2014), and 35 studies comprising a total of 3798 participants were included in the meta-analysis. The results indicated that crude peripheral blood BDNF levels may be lower in bipolar disorder patients overall (Hedges' g=-0.28, 95% CI: -0.51 to -0.04, P=0.02) and in serum of manic (g=-0.77, 95% CI: -1.36 to -0.18, P=0.01) and depressed (g=-0.87, 95% CI: -1.42 to -0.32, P=0.002) bipolar disorder patients compared with healthy control subjects. No differences in peripheral BDNF levels were observed between affective states overall. Longer illness duration was associated with higher BDNF levels in bipolar disorder patients. Relatively low study quality, substantial unexplained between-study heterogeneity, potential bias in individual studies and indications of publication bias, was observed and studies were overall underpowered. It could thus not be excluded that identified differences between groups were due to factors not related to bipolar disorder. In conclusion, limitations in the evidence base prompt tempered conclusions regarding the role of peripheral BDNF as a biomarker in bipolar disorder and substantially improving the quality of further research is warranted.

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Disruption of perineuronal nets increases the frequency of sharp wave ripple events

et al. 2017

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Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems level memory consolidation. SWRs are initiated by CA2 or CA3 pyramidal cells (PCs) and require initial excitation of CA1 PCs as well as participation of parvalbumin (PV) expressing fast spiking (FS) inhibitory interneurons. These interneurons are relatively unique in that they represent the major neuronal cell type known to be surrounded by perineuronal nets (PNNs), lattice like structures composed of a hyaluronin backbone that surround the cell soma and proximal dendrites. Though the function of the PNN is not completely understood, previous studies suggest it may serve to localize glutamatergic input to synaptic contacts and thus influence the activity of ensheathed cells. Noting that FS PV interneurons impact the activity of PCs thought to initiate SWRs, and that their activity is critical to ripple expression, we examine the effects of PNN integrity on SWR activity in the hippocampus. Extracellular recordings from the stratum radiatum of horizontal murine hippocampal hemisections demonstrate SWRs that occur spontaneously in CA1.As compared with vehicle, pre-treatment (120 min) of paired hemislices with hyaluronidase, which cleaves the hyaluronin backbone of the PNN, decreases PNN integrity and increases SWR frequency. Pre-treatment with chondroitinase, which cleaves PNN side chains, also increases SWR frequency. Together, these data contribute to an emerging appreciation of extracellular matrix as a regulator of neuronal plasticity and suggest that one function of mature perineuronal nets could be to modulate the frequency of SWR events. K E Y W O R D Schondrotinase, hippocampus, hyaluronidase, protease, PV interneuron

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Correlation of plasma brain-derived neurotrophic factor and metabolic profiles in drug-naïve patients with bipolar II disorder after a twelve-week pharmacological intervention

Cited by 14 publications

References 66 publications

Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis

Disruption of perineuronal nets increases the frequency of sharp wave ripple events

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