Correlation of pre‐operative circulating inflammatory cytokines with restenosis and rapid angiographic stenotic progression risk in coronary artery disease patients underwent percutaneous coronary intervention with drug‐eluting stents

Sun, Jun-hong; Yu, Hanjie; Liu, Haining; Pu, Dongyu; Gao, Junhui; Jiang, Xiaodong; Liu, Xiqiang; Yan, Ai-guo

doi:10.1002/jcla.23108

Cited by 21 publications

(20 citation statements)

References 28 publications

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“…Hyperactivation of pro-inflammatory patterns, mainly characterized by cytokine storm, may increase risk of restenosis in patients who underwent PCI with stent implantation due to CHD. As recently reported by Sun et al, pre-operative increased levels of IL-6, TNF-α, and IL-23 may efficiently predict risk of restenosis after PCI associated with drug-eluting stent (DES) implantation [59]. Besides ACS, the cardiovascular system may be involved in patients affected by heart failure due to hemodynamic decompensation and, in a small percentage of cases, acute myocarditis may occur without prior evidence of CVD due to ACE2 presence on cardiac myocytes, potentially leading to chronic dilated cardiomyopathy [55,60,61].…”

Section: Effects Of Sars-cov-2 On Cardiovascular Systemmentioning

confidence: 89%

Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm

Vinciguerra

Romiti

Fattouch

et al. 2020

JCM

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The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) outbreak is a public health emergency affecting different regions around the world. The lungs are often damaged due to the presence of Sars-CoV-2 binding receptor ACE2 on epithelial alveolar cells. Severity of infection varies from complete absence of symptomatology to more aggressive symptoms, characterized by sudden acute respiratory distress syndrome (ARDS), multiorgan failure, and sepsis, requiring treatment in intensive care unit (ICU). It is not still clear why the immune system is not able to efficiently suppress viral replication in a small percentage of patients. It has been documented as pathological conditions affecting the cardiovascular system, strongly associated to atherosclerotic progression, such as heart failure (HF), coronary heart disease (CHD), hypertension (HTN) and diabetes mellitus (DM), could serve as predictive factors for severity and susceptibility during Sars-CoV-2 infection. Atherosclerotic progression, as a chronic inflammation process, is characterized by immune system dysregulation leading to pro-inflammatory patterns, including interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and IL-1β. Reviewing immune system and inflammation profiles in atherosclerosis and laboratory results reported in severe COVID-19 infections, we hypothesized a pathogenetic correlation. Atherosclerosis may be an ideal pathogenetic substrate for high viral replication ability, leading to adverse outcomes, as reported in patients with cardiovascular factors. The level of atherosclerotic progression may affect a different degree of severe infection; in a vicious circle, feeding itself, Sars-CoV-2 may exacerbate atherosclerotic evolution due to excessive and aberrant plasmatic concentration of cytokines.

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Section: Effects Of Sars-cov-2 On Cardiovascular Systemmentioning

confidence: 89%

Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm

Vinciguerra

Romiti

Fattouch

et al. 2020

JCM

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“…Previous studies reported that plasma IL-12 concentrations are significantly increased in many types of atherosclerosis and atherosclerotic cardiovascular disease, including stable angina pectoris (SAP), non-ST segment elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI), acute myocardial infarction (AMI), and gradually increased SAP, unstable angina pectoris (UAP), and AMI (Zhou et al, 2001;Correia et al, 2010;Lin et al, 2012;Yong et al, 2013;Chistiakov et al, 2015;Opstad et al, 2016;Zykov et al, 2016). Clinical data showed that patients with coronary artery disease exhibit higher circulating IL-23 levels (Lin et al, 2012;Abbas et al, 2015;Sun et al, 2019a). In coronary artery disease patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES), subjects with in-stent restenosis show higher circulating IL-23 levels in peripheral blood mononuclear cells (PBMCs) (Khojasteh-Fard et al, 2012).…”

Section: Clinical Datamentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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“…Despite its wide use, there are currently no soluble markers to evaluate PMC-induced hemodynamic improvement, nor clinical outcomes. Using cytokine levels to assess outcome of percutaneous coronary intervention has shown promising results ( 17 ). Our study is the first to evaluate the impact of PMC on plasma levels of a broader range of cytokines, chemokines and growth factors, together with the frequency of activated circulating T cell subpopulations.…”

Section: Resultsmentioning

confidence: 99%

Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis

Silva

Neves

Passos

et al. 2021

Front. Cardiovasc. Med.

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Mitral stenosis (MS) is a consequence of rheumatic heart disease that leads to heart failure requiring mechanical intervention. Percutaneous mitral commissurotomy (PMC) is the treatment of choice for the intervention, and currently there are no soluble markers associated with hemodynamic improvement after PMC. This study aims to determine the changes in cytokine/chemokine plasma levels, as well as T cell activation after PMC, and to investigate their association with immediate hemodynamic improvement and clinical outcomes. Plasma samples from eighteen patients with well-defined MS who underwent PMC and 12 healthy controls were analyzed using BioPlex immunoassay. We observed that 16 out of the 27 (60%) molecules assessed were altered in patients' plasma pre-PMC as compared to control group. Of those, IL-1β, IL-12, IL-6, IL-4, PDGF, and CCL11 showed significant decrease after PMC. Stratifying the patients according to adverse outcome after a 28-month median follow up, we detected a significant reduction of IL-1β, IL-12, IL-6, IL-4, IFN-γ, CXCL-10, VEGF, FGF and PDGF post-PMC in patients without events, but not in those who presented adverse events during the follow-up. Patients with adverse outcomes had lower IL-10 pre-PMC, as compared to the ones without adverse events. In addition, the frequency of CD8+ activated memory cells was increased after PMC, while the frequency of CD4+ activated memory cells did not change. Our results show an association between the decrease of specific cytokines and changes in T cell activation with hemodynamic improvement post-PMC, as well as with long-term outcomes, suggesting their possible use as soluble markers for hemodynamic recovery after MS intervention.

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Correlation of pre‐operative circulating inflammatory cytokines with restenosis and rapid angiographic stenotic progression risk in coronary artery disease patients underwent percutaneous coronary intervention with drug‐eluting stents

Cited by 21 publications

References 28 publications

Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm

Atherosclerosis as Pathogenetic Substrate for Sars-Cov2 Cytokine Storm

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis

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