Correlation of Resistance to Proflavine and Penicillin in
            <i>Escherichia coli</i>

McKellar, R.C.; McKenzie, Colin N.; Kushner, D. J.

doi:10.1128/aac.10.4.765

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…However, Kushner and Khan (16) found no difference in the binding of proflavine to resistant and sensitive E. coli and showed that there is an active excretion system for the dye. However, a more recent study 'by McKeller et al (18) showed cross-resistance of proflavine and penicillin resistance in E. coli without any (3-lactamase activity, suggesting permeability changes in the cell envelope. A different approach, therefore, was made to study the involvement of the cell membrane in the AF resistance mutation.…”

Section: Resultsmentioning

confidence: 99%

Acriflavine-Resistant Mutant of Streptococcus cremoris

Sinha

1977

Antimicrob Agents Chemother

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Selection for resistance to acriflavine in Streptococcus cremoris resulted in cross-resistance to the drugs neomycin, streptomycin, ethidium bromide, mitomycin C, and proflavine. Furthermore, the mutants showed resistance to lytic bacteriophages to which the parental strain was sensitive, and, unlike the parent, the mutants grew well at higher temperatures (40°C). Revertants selected independently either for temperature sensitivity or for acriflavine sensitivity lost resistance to all the drugs and dyes but retained the bacteriophage resistance phenotype. The acriflavine-resistant mutation resulted in an increase in resistance by the bacterial cells to sodium dodecyl sulfate, a potent solvent of lipopolysaccharide and lipoprotein. It is suggested that the acriflavine resistance mutation determines the synthesis of a membrane substance resistant to higher temperatures.

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Section: Resultsmentioning

confidence: 99%