Correlation of SD-OCT Features and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration

Abstract

PURPOSE. To correlate retinal sensitivity in patients with neovascular age-related macular degeneration (AMD) with specific characteristics of retinal morphology.METHODS. Thirty eyes of 30 patients presenting with active choroidal neovascularization were examined by spectral domain optical coherence tomography (SD-OCT) and microperimetry (MP-1). Image-processing software was used to match a fundus photographic (FP) MP-1 image with an infraredþOCT SD-OCT image. Each MP test point for retinal sensitivity was positioned at the corresponding SD-OCT location, and the microperimetric results were evaluated.RESULTS. An intact retinal configuration was associated with a median retinal sensitivity of 15.5 dB (quartiles: 12 dB, 18 dB). The median retinal sensitivities were 0 dB (quartiles: 0 dB, 1 dB) for the neovascular complex, 4 dB (0 dB, 9 dB) for the subretinal fluid, 1 dB (0 dB, 6 dB) for the intraretinal fluid, and 0 dB (0 dB, 3 dB) for intraretinal cysts. Pigment epithelium detachment was associated with a median retinal sensitivity of 3 dB (0 dB, 8 dB), and subretinal drusen had a median value of 8 dB (5 dB, 12 dB). Deep retinal layer analyses gave low median retinal sensitivities of 0 dB (0 dB, 3 dB) for an absent retinal pigment epithelium layer and 1 dB (0 dB, 5 dB) for an absent photoreceptor layer.CONCLUSIONS. Superimposition of morphological SD-OCT features and microperimetric retinal sensitivity allowed exact determination of the differential impact of retinal alteration on the corresponding sensitivity. Individual OCT-related indicators of neurosensory integrity were distinctly correlated with visual function. ''Morphofunctional'' findings could be relevant as prognostic factors and for (re)treatment decisions. (https:// www.clinicaltrialsregister.eu/ number, 2006-005684-26.) (Invest Ophthalmol Vis Sci. 2012;53:6448-6455)

Correlation between Spectral Domain Optical Coherence Tomography and Microperimetric Findings before and after Intravitreal Bevacizumab Injection in Wet Age Related Macular Degeneration

“…This can be explained by the significant improvement of VA and improvement in stability of fixation, as well as the learning curve of patients. As opposed to Sulzbacher et al [7] who reported a strong negative correlation between central retinal thickness and central retinal sensitivity (r = -0.509, p= 0.004), we found no statistically significant correlation between the percentage of change in point thickness and the percentage of change in point sensitivity except for the lower nasal quadrant (r =-0.426, p= 0.019). This can be partially explained by the fact that the increase in retinal sensitivity in our study was not as marked as the decrease in retinal thickness or the increase in BCVA, which were both significantly high.…”

“…Central foveal thickness (CFT) was measured in microns, inner segment/outer segment (IS/OS) junction integrity and Retinal Pigment Epithelium (RPE) band were assessed. The IS/OS was graded as complete if the hyper reflective line (Interface) between the IS/OS was present, as discontinuous if the line was interrupted and the segments were only partly visible, or as completely absent [7]. The RPE layer was graded as complete if the hyper reflective band was continuous, as discontinuous if the RPE was disrupted and only partly visible, or as absent if no band was visible [7].…”

“…Incorporating microperimetry in the follow up of neovascular AMD, after anti VEGF injection could thus be a beneficial tool to evaluate retinal sensitivity even in cases with stable visual acuity and stable macular morphology on OCT. A previous study showed significant increase in mean retinal sensitivity with a decrease in absolute scotoma size 6 months after bevacizumab injection [6], a point which further encouraged us to use microperimetry in parallel with OCT in following up patients with neovascular AMD. While most studies only correlated macular structure and function by using OCT and microperimetry [7], our study aimed at correlating these two parameters as well as comparing them before and after anti VEGF injection.…”

Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity

“…6 Its uses are both clinical and for research. 7,8,9,10,11 In the present study we assess CQ and HCQ toxicity using microperimetry. Our purpose is to describe the value of microperimetry as a high sensitivity test for the screening of CQ and HCQ retinopathy.…”

Correlation of OCT Characteristics and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration in the Course of Monthly Ranibizumab Treatment

“…8 In an extended step, the functional treatment response of distinct initial SD-OCT findings was evaluated using the followup mode of both imaging devices.…”