Correlation of serological markers and thrombocytopenia in early diagnosis of dengue infection

Ingale, Suchita Vikas; Upadhye, Aditi J.; Upadhye, Jayshree J.

doi:10.18203/2320-6012.ijrms20180428

Cited by 6 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dengue specific IgM can be detected in blood only after 3 to 5 days of illness; hence it cannot be used as an early diagnostic marker. 19 Many studies conducted in various hospital have obtained a wide range of sensitivity (48.5 to 98.7%) and specificity (71.42 to 100%) of ICT based RDTs compared with ELISA, similarly in the our study, we found a sensitivity and specificity of 98 % and 74% respectively for NS1 antigen detection and 76% and 90% respectively for IgM Antibody detection. As our study indicates that NS1 antigen is highly sensitive, it is an effective tool for early dengue infection.…”

Section: Discussionsupporting

confidence: 83%

Comparison of Immuno-chromatography Test with ELISA for Acute Dengue Diagnosis at Tertiary Care Centre

Pattanayak¹,

Gaur²,

Kumar³

et al. 2019

IJCMR

View full text Add to dashboard Cite

Introduction: In the recent few decades, there had been a dramatic rise in the global incidence of dengue. As the disease is associated with high mortality and morbidity, a rapid and accurate diagnosis is essential for early appropriate management and for prevention of complications. Now days, a variety of rapid diagnostic tests (RDTs) kits and Enzyme Linked Immuno Sorbent Assay (ELISA) based test kits are available. In this present study we have attempted to do a diagnostic test evaluation of rapid ICT with ELISA for detection of NS1 antigen and IgM antibody for acute dengue diagnosis. Material and Methods: A Cross-Sectional study was carried out in the Department of Microbiology, Govt. Medical College, Raigarh from November 2017 to October 2018. 1200 suspected serum samples were tested for dengue identification by Immuno-chromatography (ICT) based RDT kit (J. Mitra and Co. Pvt.Ltd, India) which detects NS1 antigen, IgM and IgG antibodies. From the Dengue rapid reactive samples test done by ICTs were subjected to ELISA tests for Confirmation NS1 antigen and IgM antibodies. Results: The Rapid Dengue Test showed a sensitivity and specificity of 98% and 74% for NS1 antigen detection and 76% and 90% for IgM Antibody detection. Conclusion: Good sensitivity and specificity of rapid diagnostic tests for early detection of dengue was observed. These kits are suitable for early detection of dengue cases, as with high sensitivity and specificity it can help in early screening of patients and can further limit the spread of disease where ELISA facilities are not available.

show abstract

Section: Discussionsupporting

confidence: 83%

Comparison of Immuno-chromatography Test with ELISA for Acute Dengue Diagnosis at Tertiary Care Centre

Pattanayak¹,

Gaur²,

Kumar³

et al. 2019

IJCMR

View full text Add to dashboard Cite

show abstract

“…Thrombocytopenia is a common clinical condition found in dengue and a predictive biomarker for the severity of dengue [8,9,15]. More than 80% of the total patients had thrombocytopenia in this study and all 09 leaking patients on the admission day had suffered from severe thrombocytopenia.…”

Section: Discussionmentioning

confidence: 54%

The clinical profile, hematological parameters and liver transaminases of Dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka

Jayadas

Kumanan

Arasaratnam

et al. 2019

Preprint

View full text Add to dashboard Cite

Objective Objective of the study is to evaluate the on-admission day symptoms and signs clinical, hematological parameters and liver transaminases of the dengue NS1 positive patients who got admitted on different clinical phases (Febrile phase (day 1-3) and Critical phase(day 4-5) ) of dengue at medical wards of Jaffna Teaching Hospital. Results Blood samples were collected from 150 suspected dengue patients from day 1 to 5 of the illness. Seventy-eight patients were positive for Dengue NS1, according to the WHO proposed dengue clinical phase framework 37 patients were from febrile phase and 41 patients from critical phase. Patients who admitted on critical phase framework suffered from leukopenia, thrombocytopenia. 09 patients had the evidence of leakage with fever and the leakers had significant rise in hemoglobin, hematocrit and liver transaminase levels which are considered as severe form of disease.

show abstract

“…Although other dengue confirmatory tests require a well-equipped laboratory, rapid NS1 test can be performed in a hospital with lack of laboratory facility. Apart from the dengue specific parameters, platelet count is a prognostic laboratory parameter which is available to identify severity of dengue, even though thrombocytopenia is not an early indicator of severe dengue, but it helps in predicting the progression of disease [8, 9].…”

Section: Introductionmentioning

confidence: 99%

The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka

et al. 2019

View full text Add to dashboard Cite

Objective Objective of the study is to evaluate the on-admission day symptoms and signs, clinical, hematological parameters and liver transaminases of the dengue NS1 positive patients who got admitted on different clinical phases [Febrile phase (day 1–3) and Critical phase(day 4–5)] of dengue at medical wards of Jaffna Teaching Hospital. Results Blood samples were collected from 150 suspected dengue patients from day 1 to 5 of the illness. Seventy-eight patients were positive for dengue NS1, according to the WHO proposed dengue clinical phase framework 37 patients were from febrile phase and 41 patients from critical phase. Patients who admitted on critical phase framework suffered from leukopenia and thrombocytopenia. Nine patients had the evidence of leakage with fever and the leakers had significant rise in hemoglobin, hematocrit and liver transaminase levels which are considered as severe form of the disease.

show abstract

Correlation of serological markers and thrombocytopenia in early diagnosis of dengue infection

Cited by 6 publications

References 3 publications

Comparison of Immuno-chromatography Test with ELISA for Acute Dengue Diagnosis at Tertiary Care Centre

Comparison of Immuno-chromatography Test with ELISA for Acute Dengue Diagnosis at Tertiary Care Centre

The clinical profile, hematological parameters and liver transaminases of Dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka

The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka

Contact Info

Product

Resources

About