Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Zhang, Kai; Xue, Bizhen; Yuan, Yuexing; Wang, Yao

doi:10.1155/2019/4353075

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…There is also evidence of its prognostic value for microvascular complications such as retinopathy and CKD [97]. Furthermore, there is evidence that 1,5-AHG is a valuable marker of diabetes progression for individuals affected by diabetic nephropathy in which the determination of HbA1c is not recommended [72,97,104]. Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are a class of drugs that lower glucose concentrations by an insulin-independent mechanism, reducing renal reabsorption of glucose and increasing its urinary elimination.…”

Section: 5-anhydroglucitolmentioning

confidence: 99%

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

et al. 2022

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Purpose of Review Diabetes mellitus is a complex, chronic illness characterized by elevated blood glucose levels that occurs when there is cellular resistance to insulin action, pancreatic β-cells do not produce sufficient insulin, or both. Diabetes prevalence has greatly increased in recent decades; consequently, it is considered one of the fastest-growing public health emergencies globally. Poor blood glucose control can result in long-term micro- and macrovascular complications such as nephropathy, retinopathy, neuropathy, and cardiovascular disease. Individuals with diabetes require continuous medical care, including pharmacological intervention as well as lifestyle and dietary changes. Recent Findings The most common form of diabetes mellitus, type 2 diabetes (T2DM), represents approximately 90% of all cases worldwide. T2DM occurs more often in middle-aged and elderly adults, and its cause is multifactorial. However, its incidence has increased in children and young adults due to obesity, sedentary lifestyle, and inadequate nutrition. This high incidence is also accompanied by an estimated underdiagnosis prevalence of more than 50% worldwide. Implementing successful and cost-effective strategies for systematic screening of diabetes mellitus is imperative to ensure early detection, lowering patients' risk of developing life-threatening disease complications. Therefore, identifying new biomarkers and assay methods for diabetes mellitus to develop robust, non-invasive, painless, highly-sensitive, and precise screening techniques is essential. Summary This review focuses on the recent development of new clinically validated and novel biomarkers as well as the methods for their determination that represent cost-effective alternatives for screening and early diagnosis of T2DM.

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Section: 5-anhydroglucitolmentioning

confidence: 99%

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

et al. 2022

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“…OC is related to the average serum blood glucose level within a period of time and can be regarded as a protective factor for glucose metabolism in the long run [8]. However, HbA1c is not applicable to evaluating short-term blood glucose control or blood glucose uctuations [25], but GA and 1,5-AG can provide supplementary information for this.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum osteocalcin and different blood glucose markers in patients with type 2 diabetes

Pan,

Han,

Yuan

et al. 2024

Preprint

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A large number of clinical and animal studies have demonstrated that osteocalcin (OC) secreted by osteoblasts plays an important role in glucose metabolism. The purpose of this study was to further investigate the correlation between OC and different blood glucose markers in patients with type 2 diabetes.A total of 480 patients were divided into male group(n = 258) and postmenopausal female group(n = 258). OC, Glycated hemoglobin (HbA1c), Glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) were measured. The correlation between serum osteocalcin level and different blood glucose markers were analyzed by Spearman correlation analysis and multiple linear regression. Spearman correlation analysis showed that in the male group, the OC level was negatively correlated with HbA1c (r=-0.252, p < 0.001) and GA (r = 0.158, p = 0.011), but positively correlated with 1, 5-AG (r = 0.204, p < 0.001). Similarly, in the postmenopausal female group, the OC level was found to have a negative relation with HbA1c (r=-0.286, p < 0.001) and GA (r=-0.160, p = 0.017), and a positive relation with 1, 5-AG (r = 0.329, p < 0.001). Different models were used to adjust for confounding factors. According to multiple stepwise regression analysis results, OC was an independent factor affecting the HbA1c and 1, 5-AG levels in both the male group and the postmenopausal female group. Serum osteocalcin was correlated with glycemic function in type 2 diabetes mellitus, and could be taken as an independent factor affecting not only long-term blood glucose but also short-term blood glucose, especially the postprandial hyperglycemia state.

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“…Similarly to 1,5-AG, uric acid (UA) is mostly reabsorbed in the proximal tubules; albeit via another transporter, the urate transporter. A correlation between the serum levels of UA and 1,5-AG has been reported in diabetic patients with early-stage chronic kidney disease (CKD) [ 9 , 10 ]. In patients with advanced CKD, serum UA levels occasionally increase with disease progression due to a decreased glomerular filtration rate (GFR).…”

Section: Introductionmentioning

confidence: 99%

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis

Tanaka¹,

Sakasai-Sakai

Motomiya³

et al. 2021

Diabetol Metab Syndr

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Background 1,5-anhydroglucitol is a reduction product of 1,5-anhydrofructose. Circulating 1,5-anhydroglucitol is usually excreted by the kidneys and is reabsorbed via sodium-glucose co-transporter 4 in the renal tubules. In patients on hemodialysis, serum levels of 1,5-anhydroglucitol have been reported to be low; however, the underlying mechanism remains unclear. Methods We measured inter-dialysis changes in the levels of serum 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products (AGEs) in 78 patients on hemodialysis. Serum levels of 1,5-anhydrofructose-derived AGEs were also determined using a polyclonal antibody. Results The serum 1,5-anhydroglucitol level was decreased to as low as 2.0 μg/mL in the regular hemodialysis group; however, we could not verify changes in the serum 1,5-anhydroglucitol level during inter-dialysis days because of undetectable levels in 29 patients. The measured serum level of 1,5-anhydrofructose-derived AGEs was significantly increased in both patient groups. In addition, the 1,5-anhydrofructose-derived AGEs/1,5-anhydroglucitol ratio was higher in patients on hemodialysis than in controls. Conclusions Accelerated glycation of 1,5-anhydrofructose is one possible mechanism by which serum 1,5-anhydroglucitol levels are lowered in patients on HD, and we propose that the 1,5-anhydrofructose-derived AGEs/1,5-anhydroglucitol ratio should be measured in clinical settings in which patients have low serum levels of 1,5-AG.

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Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Cited by 4 publications

References 33 publications

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

Correlation between serum osteocalcin and different blood glucose markers in patients with type 2 diabetes

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis

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