Correlation of Serum Albumin Level to Lung Ultrasound Score and Its Role as Predictors of Outcome in Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study

Chaudhuri, Souvik; Maddani, Sagar S; Rao, Shwethapriya; Gauni, Sirish; Arjun, N R; Todur, Pratibha; Gupta, Nitin

doi:10.1155/2021/4594790

Cited by 3 publications

(6 citation statements)

References 33 publications

(61 reference statements)

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“…Overall, 13 cohort studies, including eight prospective studies [ 15 , 17 , 19 , 20 , 22 – 24 , 26 ] and five retrospective studies [ 14 , 16 , 18 , 21 , 25 ], were analyzed in this meta-analysis. The characteristics of the included studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Among the included patients, 343 patients (33.6%) died during hospitalization. The difference of LUS score at baseline between non-survivors and survivors were reported in 11 studies [ 14 – 17 , 19 – 21 , 23 – 26 ], and RR of in-hospital mortality between patients with high versus low LUS score were reported in six studies [ 18 , 20 , 22 , 23 , 25 , 26 ]. Median of LUS score was selected as the cutoff value in four studies [ 18 , 20 , 22 , 23 ], while the receiver operating characteristic (ROC) analysis derived cutoff value was used in the other two studies [ 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…The difference of LUS score at baseline between non-survivors and survivors were reported in 11 studies [ 14 – 17 , 19 – 21 , 23 – 26 ], and RR of in-hospital mortality between patients with high versus low LUS score were reported in six studies [ 18 , 20 , 22 , 23 , 25 , 26 ]. Median of LUS score was selected as the cutoff value in four studies [ 18 , 20 , 22 , 23 ], while the receiver operating characteristic (ROC) analysis derived cutoff value was used in the other two studies [ 25 , 26 ]. Univariate analysis was used to determine the association between LUS score and in-hospital mortality in two studies [ 14 , 18 ], age was controlled in the remaining 11 studies [ 15 – 17 , 19 – 26 ], with nine of them also controlled for other confounding factors [ 15 , 19 – 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Lung ultrasound score and in-hospital mortality of adults with acute respiratory distress syndrome: a meta-analysis

Wang,

2024

BMC Pulm Med

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Background Lung ultrasound (LUS) score could quantitatively reflect the lung aeration, which has been well applied in critically ill patients. The aim of the systematic review and meta-analysis was to evaluate the association between LUS score at admission and the risk of in-hospital mortality of adults with acute respiratory distress syndrome (ARDS). Methods Toachieve the objective of this meta-analysis, we conducted a thorough search of PubMed, Embase, Cochrane Library, and the Web of Science to identify relevant observational studies with longitudinal follow-up. We employed random-effects models to combine the outcomes, considering the potential influence of heterogeneity. Results Thirteen cohort studies with 1,022 hospitalized patients with ARDS were included. Among them, 343 patients (33.6%) died during hospitalization. The pooled results suggested that the LUS score at admission was higher in non-survivors as compared to survivors (standardized mean difference = 0.73, 95% confidence interval [CI]: 0.55 to 0.91, p < 0.001; I2 = 25%). Moreover, a high LUS score at admission was associated with a higher risk of in-hospital mortality of patients with ARDS (risk ratio: 1.44, 95% CI: 1.14 to 1.81, p = 0.002; I2 = 46%). Subgroup analyses showed consistent results in studies with LUS score analyzed with 12 or 16 lung regions, and in studies reporting mortality during ICU or within 1-month hospitalization. Conclusion Our findings suggest that a high LUS score at admission may be associated with a high risk of in-hospital mortality of patients with ARDS.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Lung ultrasound score and in-hospital mortality of adults with acute respiratory distress syndrome: a meta-analysis

Wang,

2024

BMC Pulm Med

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“…The common ones are fever, malnutrition in sepsis, gut losses, and losses from damage to the glomerular basement membrane and hence it cannot have sole control over the extravasation of fluids in the pulmonary interstitium. 26 , 29 Also, we obtained albumin values on day 1, and serial monitoring was not analyzed. In our study, we found that the cumulative fluid balance at 1 week was significantly lower amongst the EVLW+ group when compared to the other.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Extravascular Lung Water Using Lung Ultrasound in Critically Ill Patients Admitted to Intensive Care Unit

Mustafi,

Talwar,

Krishna

et al. 2024

Indian Journal of Critical Care Medicine

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A bstract Background Lung ultrasound (LUS) is a simple bedside tool to assess overhydration. Our study aimed to assess extravascular lung water (EVLW) using B-lines and correlate it with weaning, duration of mechanical ventilation, and mortality in critically ill patients admitted to the intensive care unit (ICU). Patients and methods 150 mechanically ventilated ICU patients prospectively observed over 18 months, with their demographic and clinical data noted. Extravascular lung water was monitored using LUS in four intercostal spaces (ICS) from day 1 to day 5, day 7, day 10, and weekly thereafter. Pulmonary fluid burden was graded as low (1–10), moderate (11–20), and high (21–32). Weaning outcome, duration of weaning, mechanical ventilation, ICU stay, and mortality were compared in patients with and without EVLW. Results Out of 150, 54 patients (36.0%) had EVLW. The mean lung score amongst our patients was 8.57 ± 6.0. The mean time for detection of EVLW was 1.43 ± 2.24 days. Lung score was low in 40 (26.67%) patients, moderate in 9 (6.00%) patients, and high in 5 (3.33%) patients. Incidence of weaning failure ( p -value = 0.006), duration of weaning, mechanical ventilation, ICU stay ( p -value < 0.0001 each), and overall mortality were significantly higher in patients with EVLW ( p -value = 0.006). Conclusion We conclude that a good proportion of critically ill patients have EVLW. Extravascular lung water significantly increases the duration of weaning, mechanical ventilation days, ICU stay, and overall mortality in critically ill patients. How to cite this article Rajpal M, Talwar V, Krishna B, Mustafi SM. Assessment of Extravascular Lung Water Using Lung Ultrasound in Critically Ill Patients Admitted to Intensive Care Unit. Indian J Crit Care Med 2024;28(2):165–169.

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“…Besides, on the day of admission to ICU, serum albumin has nothing to do with the degree of pulmonary degassing described by LUSS in ARDS patients. Serum albumin level < 3.25 g/dL increases the chances of prolonging ICU stay (≥ 10 days), but it cannot predict the mortality rate 33 . This is also consistent with our conclusion, suggesting that ARDS may be the main risk of all-cause death on the 28th day.…”

Section: Discussionmentioning

confidence: 99%

Serum albumin and the short-term mortality in individuals with congestive heart failure in intensive care unit: an analysis of MIMIC

Chao

Cui

Wang

et al. 2022

Sci Rep

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Decreased albumin levels are common in congestive heart failure (CHF), but little is known about its role in mortality risk in CHF. This study developed a cohort prediction model based on 7121 individuals with heart failure to evaluate the short-term mortality and prognostic role of albumin in patients with CHF. The cohort was from intensive care unit between 2001 and 2012 in a publicly available clinical database in intensive care called MIMIC III. We used a generalized additive model to determine the nonlinear correlation between serum albumin and 14th day, 28th day and 90th day all-cause mortality in patients with heart failure. The results showed that serum albumin is an independent risk factor for 14th, 28th and 90th day all-cause mortality, and has a linear relationship with all-cause mortality in congestive heart failure. Cox regression analysis using restricted cubic spline with albumin as continuous parameter showed that the decrease of albumin level is directly related to the increase of mortality (14th day mortality: hazard ratio [HR], 0.65 [95% CI, 0.58 to 0.73]); 28th day mortality: HR, 0.56 [95% CI, 0.51 to 0.63]; 90th day mortality: HR, 0.52 [95% CI, 0.47 to 0.57]; P for trend < 0.001). The multivariate adjusted association between albumin (as a continuous variable) and all-cause mortality on the 90th days is mixed by ARDS [HR, 0.64, 95% CI (0.47–0.87), P = 0.005]. The all-cause mortality on the 90th day predicted better clinical results with the all-cause mortality on the 14th day.

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Correlation of Serum Albumin Level to Lung Ultrasound Score and Its Role as Predictors of Outcome in Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study

Cited by 3 publications

References 33 publications

Lung ultrasound score and in-hospital mortality of adults with acute respiratory distress syndrome: a meta-analysis

Lung ultrasound score and in-hospital mortality of adults with acute respiratory distress syndrome: a meta-analysis

Assessment of Extravascular Lung Water Using Lung Ultrasound in Critically Ill Patients Admitted to Intensive Care Unit

Serum albumin and the short-term mortality in individuals with congestive heart failure in intensive care unit: an analysis of MIMIC

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